DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk7 and Asic4

DIOPT Version :9

Sequence 1:	NP_609016.2	Gene:	ppk7 / 33886	FlyBaseID:	FBgn0031802	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_071570.2	Gene:	Asic4 / 63882	RGDID:	621068	Length:	539	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	118/523 - (22%)
Similarity:	187/523 - (35%)	Gaps:	138/523 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 FGKRTTIHGLDRLLSAKASRWERFVWLCTFVSAFLGAVYVCLILSARY-NAAHFQTVVDSTRFPV 101
            |...:|:|||.|..........|.:|:...:::....:|....|:..| ...|...:..:...||
  Rat    45 FASTSTLHGLGRACGPGPHGLRRTLWVLALLTSLAAFLYQAASLARGYLTRPHLVAMDPAAPAPV 109

  Fly   102 YRIPFPVITICNRNRLNWQRLAEAKSRFLAN---------------GSNSAQQELFELIVGTYDD 151
              ..||.:|:||.||.....|::|....|||               |....:.::.:::..|
  Rat   110 --AGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRT--- 169

  Fly   152 AYFGHFQSFERLRNQPTELLNYVNFSQVVDFMTWRCNELLAECLWRHHAYDCCEI--FSKRRSKN 214
               ||         |..::|...|||                   .||    |..  ||...::.
  Rat   170 ---GH---------QLADMLKSCNFS-------------------GHH----CSASNFSVVYTRY 199

  Fly   215 GLCWAFNSLETEEGRRMQLLDPM--WPWRTGSAGPMSALSVRVLIQPAKHWPGHRETNAMK---G 274
            |.|:.||:            ||.  .|.|.|..|  |.|.:.:.||..::.|..||||...   |
  Rat   200 GKCYTFNA------------DPQSSLPSRAGGMG--SGLEIMLDIQQEEYLPIWRETNETSFEAG 250

  Fly   275 IDVMV---TEPFVWHNNPFFVAANTETTMEIEPVIYFYDNDTRGVRSDQRQCVFDDEHNSKDFKS 336
            |.|.:   .||...|...|.|:...:|.:..:.....|.....|      .|..:.:....:
  Rat   251 IRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWG------NCRAESKLREPE--- 306

  Fly   337 LQGY-VYMIENCQSECHQEYLVRYCNCTM------DLLFPPGQYRSCRAQDLLCLAEH--NDLLI 392
            |||| .|.:..|:..|.:|.:::.|:|.|      :.:.||..|..|        |:|  :.|..
  Rat   307 LQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIEC--------ADHTLDSLGG 363

  Fly   393 YSHNPGEKEFVRNQFQGMSCKCFRNCYSLNYISDVRPAFLP--------------PDVYANNSYV 443
            .|..|              |.|...|....|..::....:|              .:.|...:::
  Rat   364 GSEGP--------------CFCPTPCNLTRYGKEISMVKIPNRGSARYLARKYNRNETYIRENFL 414

  Fly   444 DLDVHFRFETIMVYRTSLVFGWVDLMVSFGGIAGLFLGCSLISGMELAYFLCIEVPAFGLDGLRR 508
            .|||.|...|.........:|...|:...||..|||:|.|:::.:|:..:: .||   ..|.|:|
  Rat   415 VLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYI-YEV---SWDRLKR 475

  Fly   509 RWK 511
            .|:
  Rat   476 VWR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:279230	112/503 (22%)
Asic4	NP_071570.2	ASC	40..488	CDD:295594	118/523 (23%)
Asic4	NP_071570.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	111	1.000	Domainoid score	I6095
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8907
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920