Protein Alignment ppk7 and Asic5

DIOPT Version :10

• Sequence 1: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_071563.1
• Gene: Asic5 / 63866
• RGDID: 69295
• Length: 495
• Species: Rattus norvegicus
• Alignment Length: 531
• Identity: 107/531 - (20%)
• Similarity: 173/531 - (32%)
• Gaps: 178/531 - (33%)

  Fly    38 FGKRTTIHGLDRLLSAKASRWERFVWLCTFVSAFLGAV--YVCLILSARYNAAHFQTVVDSTRFP 100
            |...|:.||:.. ::...::..:.:||    |..||:|  .|..|.|...|...:.|........
  Rat    41 FAISTSFHGIHN-IAQNQNKVRKVIWL----SVVLGSVSLLVWQIYSRLVNYFMWPTTTSIEVQY 100

  Fly   101 VYRIPFPVITICNRNRLNWQRLAEAKSRF-----------------LANGSNSAQQELFELIVGT 148
            |.:|.||.:|.||.||..    .||.|||                 ..:|:|:...|..:.:
  Rat   101 VEKIEFPAVTFCNLNRFQ----TEAVSRFGIIFFLWDIVSKVLRLQEISGNNTGSPEALDFV--- 158

  Fly   149 YDDAYFGHFQSFERLRNQPTELLNYVNFSQVVDFMTWRCNELLAECLWRHHAYDCCEIFSKR--- 210
               |...:|...|.::|...    |:|...:|.                      ||.|.|.
  Rat   159 ---ASHRNFSITEFVKNNGF----YLNHDTLVH----------------------CEFFGKTCDP 194

  Fly   211 ------RSKNGLCWAFNSLETEE--------GRRMQLLDPMWPWRTGSAGPMSALSVRVLIQPAK 261
                  .::.|.|:.||..|..:        ||.::||                |.|
  Rat   195 KDFKHVFTEYGNCFTFNYGENVQSKNKVSVSGRGLKLL----------------LDV-------- 235

  Fly   262 HWPGHRE---TNAMKGI-DVMVTEPFVWHN---NPFFVAANTETTMEIEPVIYFYDNDTRGVRSD 319
                |:|   .|.:.|. |..|.  ||.|:   .|.|......:.:.:...:......|......
  Rat   236 ----HQEEFTDNPVPGFADAGVI--FVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTIHQEYP 294

  Fly   320 QRQCVFDDEHNSKDFKSLQGYVYMIENCQSECHQEYLVRYCNCTMDLLFPPG--------QYRSC 376
            ..:|       :.|.|......|....|..||..:::.|.|.|...||  ||        :|.:|
  Rat   295 WGEC-------NPDIKLRNFTTYSTYGCLKECKAKHIQRLCGCLPFLL--PGNGVECDLLKYYNC 350

  Fly   377 RAQDL-------LC-LAEHND-------------LLIYSHNPGEK--EFVRNQFQGMSCKCFRNC 418
            .:..|       || :..||.             .:.||..|.::  :|:..:
  Rat   351 VSPILDHIERKGLCTMGTHNSSCPVPCEETEYPATIAYSTFPSQRATKFLAKK------------ 403

  Fly   419 YSLNYISDVRPAFLPPDVYANNSYVDLDVHFRFETIMVYRTSLVFGWVDLMVSFGGIAGLFLGCS 483
              ||...:          |...:.|::::::......:.:........:|:...||..|||.|.|
  Rat   404 --LNQSQE----------YIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGAS 456

  Fly   484 LISGMELAYFL 494
            ||:.:|:..:|
  Rat   457 LITIIEIIEYL 467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:459966	106/528 (20%)
Asic5	NP_071563.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000269|PubMed:27679529	1..30
		ASC	41..466	CDD:459966	106/528 (20%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456		1/1 (100%)