Protein Alignment ppk7 and SCNN1G

DIOPT Version :9

• Sequence 1: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_001030.2
• Gene: SCNN1G / 6340
• HGNCID: 10602
• Length: 649
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 125/662 - (18%)
• Similarity: 220/662 - (33%)
• Gaps: 211/662 - (31%)

  Fly    42 TTIHGLDRLLSAKASRWERFVWLCTFVSAFLGAVYVCLILSARYNAAHFQTVVDSTRFPVYRIPF 106
            |..||..|::.:: .|..|.:|:...::|....::.|.:|     ...|.||..|.:....::.|
Human    36 TNTHGCRRIVVSR-GRLRRLLWIGFTLTAVALILWQCALL-----VFSFYTVSVSIKVHFRKLDF 94

  Fly   107 PVITICNRNRLNWQRL---------------------AEAKSRFLANGSNS---AQQELFE---- 143
            |.:||||.|...:..:                     .|::.|..|...||   .:|..|.
Human    95 PAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIP 159

  Fly   144 LIV------GTYDDAYFG-----------------HFQS-----FERLRNQPTEL---------- 170
            |::      |...|.:.|                 |.:|     |:...|..::.
Human   160 LLIFDQDEKGKARDFFTGRKRKVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGIN 224

  Fly   171 -------LNYVNFSQVVDF-----MTWRCNELLAECLWRHHAYDCCEIFSKRRSKNGLCWAFNSL 223
                   |:|:|....|..     |::...|||..|.:...:.|...........:|.|:.||:.
Human   225 AIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDARNFTLFHHPMHGNCYTFNNR 289

  Fly   224 ETEEGRRMQLLDPMWPWRTGSAGPMSALSVRVLIQPAKHWPGHRETNAMKGIDVMVTEPFVWHNN 288
            |.|     .:|.      |...|....|.|.:.|...::.|....:...|         .:.|..
Human   290 ENE-----TILS------TSMGGSEYGLQVILYINEEEYNPFLVSSTGAK---------VIIHRQ 334

  Fly   289 ---PFFVAANTETTMEIEPVIYFYDNDTRGVRSDQRQCVFDDEHNSKDFKSLQGYVYMIENCQSE 350
               ||.....||....:...|..:..::..:.....||.  ::.:....:::....|.::.|...
Human   335 DEYPFVEDVGTEIETAMVTSIGMHLTESFKLSEPYSQCT--EDGSDVPIRNIYNAAYSLQICLHS 397

  Fly   351 CHQEYLVRYCNCTM--DLLFPPGQYRSCRAQDLLCLAEHNDLLIYSHNPGEKEFVRNQFQGMSCK 413
            |.|..:|..|.|..  ..|.|...|         |..:.:...:|.:....:.||:.:. |....
Human   398 CFQTKMVEKCGCAQYSQPLPPAANY---------CNYQQHPNWMYCYYQLHRAFVQEEL-GCQSV 452

  Fly   414 CFRNC----YSL-----NYISDVRPAFLPP--------DVYANNSYVDL--------DVHFRFET 453
            |...|    ::|     .:.|.|...:|.|        .|....:..||        |::.|  :
Human   453 CKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKTDLAKLLIFYKDLNQR--S 515

  Fly   454 IMVYRTSLVFGWVDLMVS-FGGIAGLFLGCSLISGMELAYFLCIEVPAFGLDGL----RRRWKAR 513
            ||....:.    :::::| |||..||::.||::..:|:     |||  |.:|..    ||:|:..
Human   516 IMESPANS----IEMLLSNFGGQLGLWMSCSVVCVIEI-----IEV--FFIDFFSIIARRQWQKA 569

  Fly   514 RQ------------------------MD-----------------LGVTVP-TP-----TLNFQQ 531
            ::                        :|                 ||..|| ||     ||..::
Human   570 KEWWAWKQAPPCPEAPRSPQGQDNPALDIDDDLPTFNSALHLPPALGTQVPGTPPPKYNTLRLER 634

  Fly   532 TTPSQLMENYIM 543
            ...:||.:..::
Human   635 AFSNQLTDTQML 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:279230	106/559 (19%)
SCNN1G	NP_001030.2	ENaC	24..630	CDD:273304	121/644 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8228
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I5132
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.870