Protein Alignment ppk7 and SCNN1D

DIOPT Version :9

• Sequence 1: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_001123885.2
• Gene: SCNN1D / 6339
• HGNCID: 10601
• Length: 802
• Species: Homo sapiens
• Alignment Length: 636
• Identity: 129/636 - (20%)
• Similarity: 197/636 - (30%)
• Gaps: 237/636 - (37%)

  Fly     7 PPSKLQQQQQPSRSSRLAQQLAQSSWQLALRFGKRTTIHGLDRLLSAKASRWERFVWLCTFVSAF 71
            ||.|...|:.       ..:|..|..:|...|....||||..||:.::.:|.:...|  ..:|
Human   203 PPPKEGHQEG-------LVELPASFRELLTFFCTNATIHGAIRLVCSRGNRLKTTSW--GLLS-- 256

  Fly    72 LGA-VYVCLILSARYNAAHFQTVVDSTRFPVYRIPFPVITICNRN-------------------- 115
            ||| |.:|..|...:.....:.|:.:......|...|::|:|:.|
Human   257 LGALVALCWQLGLLFERHWHRPVLMAVSVHSERKLLPLVTLCDGNPRRPSPVLRHLELLDEFARE 321

  Fly   116 --------------------------------RLNWQRLAEAKSRFLANGSNSAQQELFELIVGT 148
                                            .:..|||:.:.||....         |.|...|
Human   322 NIDSLYNVNLSKGRAALSATVPRHEPPFHLDREIRLQRLSHSGSRVRVG---------FRLCNST 377

  Fly   149 YDDAYFGHFQSFERLRNQPTELLNYVNFSQVVDFMTWRCNELLA--ECLWR--------HHAYDC 203
            ..|.::..:.|               ..:.|.|:..:...::||  ...|.        |....|
Human   378 GGDCFYRGYTS---------------GVAAVQDWYHFHYVDILALLPAAWEDSHGSQDGHFVLSC 427

  Fly   204 CEIFSKRRSKNGL-CWA--FNSLETEEGRRMQLLDPMW----PWRTGSAGPMSALSVRVLIQPAK 261
                    |.:|| |.|  |.:...........:|.:|    |..|...|    |.:||..||
Human   428 --------SYDGLDCQARQFRTFHHPTYGSCYTVDGVWTAQRPGITHGVG----LVLRVEQQP-- 478

  Fly   262 HWPGHRETNAMKGIDVMV----TEPFVWHNNPFFVAANTETTMEIEPVIYFYDNDTRGVRSDQRQ 322
            |.|   ..:.:.||.|||    ..||:.|:: |.|...||.|:.|.      :::...:.|....
Human   479 HLP---LLSTLAGIRVMVHGRNHTPFLGHHS-FSVRPGTEATISIR------EDEVHRLGSPYGH 533

  Fly   323 CVFDDE-------HNSKDFKSLQGYVYMIENCQSECHQEYLVRYCNCTMDLLFPPGQYRSCRA-- 378
            |....|       ||:.         |..:.|...|.|:.:|..|:|...|...|.....|.:
Human   534 CTAGGEGVEVELLHNTS---------YTRQACLVSCFQQLMVETCSCGYYLHPLPAGAEYCSSAR 589

  Fly   379 ------------QDLLCLAEHNDLLIYSHNP------------------------------GEKE 401
                        |||    |.:.|...|..|                              ||
Human   590 HPAWGHCFYRLYQDL----ETHRLPCTSRCPRPCRESAFKLSTGTSRWPSAKSAGWTLATLGE-- 648

  Fly   402 FVRNQFQGMSCKCFRNCYSLNYISDVRPAFLPPDVYANNSYVDLDVHFRFETIMVYRT---SLVF 463
                  ||:..:..|...||..|:.|              |.:|:          ||:   :.|:
Human   649 ------QGLPHQSHRQRSSLAKINIV--------------YQELN----------YRSVEEAPVY 683

  Fly   464 GWVDLMVSFGGIAGLFLGCSLISGMELAYFLCIEVPA----FGLDGLRRRW 510
            ....|:.:.|.:..|:.|.|::|.:||...| ::..|    .|...|||.|
Human   684 SVPQLLSAMGSLCSLWFGASVLSLLELLELL-LDASALTLVLGGRRLRRAW 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:279230	115/582 (20%)
SCNN1D	NP_001123885.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..211		3/7 (43%)
		ENaC	219..784	CDD:273304	124/613 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	738..777

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820