Protein Alignment ppk7 and SCNN1A

DIOPT Version :9

• Sequence 1: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_001153048.1
• Gene: SCNN1A / 6337
• HGNCID: 10599
• Length: 728
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 125/632 - (19%)
• Similarity: 202/632 - (31%)
• Gaps: 212/632 - (33%)

  Fly    15 QQPSRSSRLAQQLAQSSWQLALRFGKRTTIHGLDRLLSAKASR-----WERFVWLCTFVSAFLGA 74
            |||:.......:..:|..:|...|...|||||..||:.::.:|     | ..:|||||     |.
Human    98 QQPTAEEEALIEFHRSYRELFEFFCNNTTIHGAIRLVCSQHNRMKTAFW-AVLWLCTF-----GM 156

  Fly    75 VYVCL-ILSARYNAAHFQTVVDSTRFPVY--------RIPFPVITICNRNRLNWQRLAEAKSRFL 130
            :|... :|...|.:           :||.        ::.||.:|||.   ||..|..|.|...
Human   157 MYWQFGLLFGEYFS-----------YPVSLNINLNSDKLVFPAVTICT---LNPYRYPEIKEEL- 206

  Fly   131 ANGSNSAQQELFELIVGTYDDAYFGHFQSF---------------------ERLRNQP------- 167
                    :||..:...|..|.|  .:.||                     :|||..|
Human   207 --------EELDRITEQTLFDLY--KYSSFTTLVAGSRSRRDLRGTLPHPLQRLRVPPPPHGARR 261

  Fly   168 --TELLNYVNFSQVVDFMTWR-----CNELLAECL--------------WRHHAYDCCE------ 205
              :...:..:.:..||:..|:     ||:..::|.              :|.|..:...
Human   262 ARSVASSLRDNNPQVDWKDWKIGFQLCNQNKSDCFYQTYSSGVDAVREWYRFHYINILSRLPETL 326

  Fly   206 -----------IFSKRRSKNGLCWAFNSLETEEGRRMQLLDPMWP-------------WRTGSAG 246
                       ||:.|         ||.:...:........||:.             |.:...|
Human   327 PSLEEDTLGNFIFACR---------FNQVSCNQANYSHFHHPMYGNCYTFNDKNNSNLWMSSMPG 382

  Fly   247 PMSALSVRVLIQPAKHWPGHRETNAMKGIDVMV---TEPFVWHNNPFFVAANTETTMEIEPVIYF 308
            ..:.||:.:..:.....|   ..:.:.|..|||   .||....:..|.:....||::.:.....
Human   383 INNGLSLMLRAEQNDFIP---LLSTVTGARVMVHGQDEPAFMDDGGFNLRPGVETSISMRKETL- 443

  Fly   309 YDNDTRGVRSDQRQCVFDDEHNSKD--FKSLQGYVYMIENCQSECHQEYLVRYCNCTMDLLFPP- 370
               |..|  .|...|.    .|..|  .::|....|..:.|...|.||.:::.|.|.  .:|.|
Human   444 ---DRLG--GDYGDCT----KNGSDVPVENLYPSKYTQQVCIHSCFQESMIKECGCA--YIFYPR 497

  Fly   371 -------------------------------GQYRSCRAQDLLCLAEHNDLLI-YSHNPG--EKE 401
                                           |.:..||..   |......|.. ||..|.  .:|
Human   498 PQNVEYCDYRKHSSWGYCYYKLQVDFSSDHLGCFTKCRKP---CSVTSYQLSAGYSRWPSVTSQE 559

  Fly   402 FVRNQFQGMSCKCFRNCYSLNYISDVRPAFLPPDVYANNSYVDLDVHFRFETIMVYRTSLVFGWV 466
            :|   ||.:|   .:|.|::|              ...|....:::.|:.........|.....|
Human   560 WV---FQMLS---RQNNYTVN--------------NKRNGVAKVNIFFKELNYKTNSESPSVTMV 604

  Fly   467 DLMVSFGGIAGLFLGCSLISGMELAYFLCIEVPAFGLDGLRRRWKAR 513
            .|:.:.|....|:.|.|::|.:|:|. |..::.......|.||:::|
Human   605 TLLSNLGSQWSLWFGSSVLSVVEMAE-LVFDLLVIMFLMLLRRFRSR 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:279230	115/587 (20%)
SCNN1A	NP_001153048.1	ENaC	113..706	CDD:273304	122/617 (20%)
		deg-1	121..631	CDD:273309	115/588 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820