Protein Alignment ppk7 and Asic5

DIOPT Version :10

• Sequence 1: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_067345.1
• Gene: Asic5 / 58170
• MGIID: 1929259
• Length: 495
• Species: Mus musculus
• Alignment Length: 279
• Identity: 60/279 - (21%)
• Similarity: 92/279 - (32%)
• Gaps: 91/279 - (32%)

  Fly    62 LHDNQPEVSEILMVLDSSDEEDEDTPALPAEAVSLVESDLDDVIYKLYGSLCLDQIKWSNSILLH 126
            |.||...:.||.:      |.:|..|......|||                 |..:|.:|.:.||
Mouse   214 LTDNLVALKEIRL------EHEEGAPCTAIREVSL-----------------LKDLKHANIVTLH 255

  Fly   127 EAEQNQATSDRI-EAQMKTLKSAFQDIQNNIYSVRTTKID---------------------KPEL 169
            :....|.:...: |...|.||....|..|:|: :...|:.                     ||:.
Mouse   256 DIIHTQKSLTLVFEYLDKDLKQYLDDCGNSIH-MHNVKLFLFQLLRGLNYCHRRKVLHRDLKPQN 319

  Fly   170 IIEDDATSEQIAH---ERFRSMLSKTETLHREPVQVGCQYFGVRTTVLASW-TECKVLEVKSDVS 230
            ::.:|....::|.   .|.:|:.:||.:                ..|:..| ....:|...:|.|
Mouse   320 LLINDRGELKLADFGLARAKSIPTKTYS----------------NEVVTLWYRPPDILLGSTDYS 368

  Fly   231 IETH-YQSGCTMYTVRFLTGD---PKPTVITAKHLAYTTPPNVKLLLGTRVVARTSSATQDGMNR 291
            .:.. :..||..|.:.  ||.   |..||....|..:.       ||||     .:..|..|:
Mouse   369 TQIDMWGVGCIFYEMS--TGRPLFPGSTVEEELHFIFK-------LLGT-----PTEETWPGI-- 417

  Fly   292 TFYAGTVLESLSSYNKYRY 310
                 |..|...|||..||
Mouse   418 -----TSNEEFISYNYPRY 431

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:459966	60/279 (22%)
Asic5	NP_067345.1	Binds the plasma membrane and stabilizes the channel in the closed state. /evidence=ECO:0000250|UniProtKB:Q9R0W5	1..30
		ASC	41..466	CDD:459966	60/279 (22%)
		GAS motif, ion selectivity filter. /evidence=ECO:0000250|UniProtKB:P78348	454..456