DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk7 and ASIC4

DIOPT Version :9

Sequence 1:	NP_609016.2	Gene:	ppk7 / 33886	FlyBaseID:	FBgn0031802	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_061144.4	Gene:	ASIC4 / 55515	HGNCID:	21263	Length:	539	Species:	Homo sapiens

Alignment Length:	524	Identity:	123/524 - (23%)
Similarity:	189/524 - (36%)	Gaps:	140/524 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 FGKRTTIHGLDRLLSAKASRWERFVW---LCTFVSAFLGAVYVCLILSARY-NAAHFQTVVDSTR 98
            |...:|:|||.|..........|.:|   |.|.::|||   |....|:..| ...|...:..:..
Human    45 FASTSTLHGLGRACGPGPHGLRRTLWALALLTSLAAFL---YQAAGLARGYLTRPHLVAMDPAAP 106

  Fly    99 FPVYRIPFPVITICNRNRLNWQRLAEAKSRFLAN---------------GSNSAQQELFELIVGT 148
            .||  ..||.:|:||.||.....|::|....|||               |....:.::.:::..|
Human   107 APV--AGFPAVTLCNINRFRHSALSDADIFHLANLTGLPPKDRDGHRAAGLRYPEPDMVDILNRT 169

  Fly   149 YDDAYFGHFQSFERLRNQPTELLNYVNFSQVVDFMTWRCNELLAECLWRHHAYDCCEI--FSKRR 211
                  ||         |..::|...|||                   .||    |..  ||...
Human   170 ------GH---------QLADMLKSCNFS-------------------GHH----CSASNFSVVY 196

  Fly   212 SKNGLCWAFNSLETEEGRRMQLLDP--MWPWRTGSAGPMSALSVRVLIQPAKHWPGHRETNAMK- 273
            ::.|.|:.||:            ||  ..|.|.|..|  |.|.:.:.||..::.|..||||...
Human   197 TRYGKCYTFNA------------DPRSSLPSRAGGMG--SGLEIMLDIQQEEYLPIWRETNETSF 247

  Fly   274 --GIDVMV---TEPFVWHNNPFFVAANTETTMEIEPVIYFYDNDTRGVRSDQRQCVFDDEHNSKD 333
              ||.|.:   .||...|...|.|:...:|.:..:.....|.....|      .|..:.|....:
Human   248 EAGIRVQIHSQEEPPYIHQLGFGVSPGFQTFVSCQEQRLTYLPQPWG------NCRAESELREPE 306

  Fly   334 FKSLQGY-VYMIENCQSECHQEYLVRYCNCTM------DLLFPPGQYRSCRAQDLLCLAEHNDLL 391
               |||| .|.:..|:..|.:|.:::.|:|.|      :.:.||..|..|        |:|.
Human   307 ---LQGYSAYSVSACRLRCEKEAVLQRCHCRMVHMPGNETICPPNIYIEC--------ADHT--- 357

  Fly   392 IYSHNPGEKEFVRNQFQGMSCKCFRNCYSLNYISDVRPAFLP--------------PDVYANNSY 442
            :.|...|.:.         .|.|...|....|..::....:|              .:.|...::
Human   358 LDSLGGGPEG---------PCFCPTPCNLTRYGKEISMVRIPNRGSARYLARKYNRNETYIRENF 413

  Fly   443 VDLDVHFRFETIMVYRTSLVFGWVDLMVSFGGIAGLFLGCSLISGMELAYFLCIEVPAFGLDGLR 507
            :.|||.|...|.........:|...|:...||..|||:|.|:::.:|:..:: .||   ..|.|:
Human   414 LVLDVFFEALTSEAMEQRAAYGLSALLGDLGGQMGLFIGASILTLLEILDYI-YEV---SWDRLK 474

  Fly   508 RRWK 511
            |.|:
Human   475 RVWR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:279230	117/504 (23%)
ASIC4	NP_061144.4	ASC	40..488	CDD:413546	123/524 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7253
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3633
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.900