Protein Alignment ppk7 and ASIC1

DIOPT Version :9

• Sequence 1: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 129/605 - (21%)
• Similarity: 205/605 - (33%)
• Gaps: 213/605 - (35%)

  Fly    38 FGKRTTIHGLDRLLSAKASRWERFVW-LCTFVSAFLG--AVYVCLILSARYNAAHFQTVVDSTRF 99
            |...:|:|||..:.|.:....:|.:| ||     |||  ||.:|:.........|:..|......
Human    21 FASSSTLHGLAHIFSYERLSLKRALWALC-----FLGSLAVLLCVCTERVQYYFHYHHVTKLDEV 80

  Fly   100 PVYRIPFPVITICNRNRLNWQR------------LAEAKSRFLANGSNSAQQELFELIVGTYDDA 152
            ...::.||.:|:||.|...:.:            ||...:|:....:..|.::..|::   .|.|
Human    81 AASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEIL---QDKA 142

  Fly   153 YFGHFQSFERLRNQPTELLNYVNFSQVVDFMTWRCNELLAECLWRHHAYDCC--EIFSKRRSKNG 215
               :|:||   :.:|      .|..:..|.......::|..|   |...:.|  |.|....::.|
Human   143 ---NFRSF---KPKP------FNMREFYDRAGHDIRDMLLSC---HFRGEVCSAEDFKVVFTRYG 192

  Fly   216 LCWAFNSLETEEGR--RMQLLDPMWPWRTGSAGPMSALSVRVLIQPAKH---WPGHRETNAMKGI 275
            .|:.|||     ||  |.:|       :|...|..:.|.:.:.||..::   |....||:...||
Human   193 KCYTFNS-----GRDGRPRL-------KTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGI 245

  Fly   276 DVMV---TEPFVWHNNPF--------------FVAANTETTMEIEPVIYFYDNDTRGVRSDQRQC 323
            .|.:   .||      ||              |||...:..:.:.|..    ...:.|..|....
Human   246 KVQIHSQDEP------PFIDQLGFGVAPGFQTFVACQEQRLIYLPPPW----GTCKAVTMDSDLD 300

  Fly   324 VFDDEHNSKDFKSLQGYVYMIENCQSECHQEYLVRYCNCTM-----DLLF-PPGQYRSCRAQDLL 382
            .||.              |.|..|:.:|...|||..|||.|     |..: .|.||:.|....|.
Human   301 FFDS--------------YSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALD 351

  Fly   383 CLAEHNDLLIYSHNPGEKEFVRNQFQGMSCKCFRNCYSLNYISDVRPAFLP-------------- 433
            .|.|.           ::|:         |.|...|....|..::....:|
Human   352 FLVEK-----------DQEY---------CVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNK 396

  Fly   434 PDVYANNSYVDLDVHF---RFETI---MVYRTSLVFGWVDLMVS--------------------- 471
            .:.|...:.:.||:.|   .:|||   ..|..:.:.|  :|:::
Human   397 SEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLG--ELLMTPVPFSCHGHGVAPYHPKAGCS 459

  Fly   472 ---------------------FGGIAGLFLGCSLISGMEL---AY-----FLCIEVPAFGLDGLR 507
                                 .||..|||:|.|:::.:||   ||     .||
Human   460 LLSHEGPPPQRPFPKPCCLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLC------------ 512

  Fly   508 RRWKARRQ-----MDLGVTV 522
            ||.|.:::     .|.||.:
Human   513 RRGKCQKEAKRSSADKGVAL 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:279230	121/569 (21%)
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	129/605 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3633
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950