DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk7 and asic4a

DIOPT Version :9

Sequence 1:	NP_609016.2	Gene:	ppk7 / 33886	FlyBaseID:	FBgn0031802	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	NP_999952.1	Gene:	asic4a / 407668	ZFINID:	ZDB-GENE-040513-5	Length:	539	Species:	Danio rerio

Alignment Length:	580	Identity:	126/580 - (21%)
Similarity:	209/580 - (36%)	Gaps:	141/580 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KLQQQQQPSRSSRLAQQLAQSSWQLALRFGKRTTIHGLDRL-----LSAKASRWERFVWLCTFVS 69
            |.:..|...:.|.:.:..:..:..|| .|...:::||::.:     |..:.:.|         ..
Zfish    17 KQKGNQDGDKESLIEESCSPPTKDLA-GFASASSLHGINHIFVSGRLGVRQTLW---------AL 71

  Fly    70 AFLGAVYVCLILSARYNAAHFQ----TVVDSTRFPVYRIPFPVITICNRNRLNWQRLAEAKSRFL 130
            |||.::.:.|..:|:...::.:    |.::....|  .:.||.:||||.||..:..|.:|....|
Zfish    72 AFLVSLALFLYQAAKCAISYLEHPHVTALNEEATP--EMVFPAVTICNINRFRFSALTDADIYHL 134

  Fly   131 ANGSNSAQQELFELIVGTYDDAYFGHFQS------------FERLRNQPTELLNYVNFSQVVDFM 183
            ||            :.|.......||..:            |.|..:|..|:|...|||
Zfish   135 AN------------LTGLPPKNKDGHKPTDLEYPAPDMQDIFNRTGHQLEEMLKSCNFS------ 181

  Fly   184 TWRCNELLAECLWRHHAYDC-CEIFSKRRSKNGLCWAFNSLETEEGRRMQLLDPMWPWRTGSAGP 247
                            ..:| .|.|:...::.|.|:.||..:|...:..|          |..|
Zfish   182 ----------------GQNCSAEDFTVVYTRYGKCYTFNGNKTTSRKTKQ----------GGMG- 219

  Fly   248 MSALSVRVLIQPAKHWPGHRETNAMK---GIDVMV---TEPFVWHNNPFFVAANTETTMEI-EPV 305
             :.|.:.:.||...:.|..:|||...   ||.|.:   .||...|...|.|:...:|.:.. |..
Zfish   220 -NGLEIMLDIQQDDYLPIWKETNETSLEAGIRVQIHSQDEPPYIHQLGFGVSPGFQTFVSCQEQR 283

  Fly   306 IYFYDNDTRGVRSDQRQCVFDDEHNSKDFKSLQGY-VYMIENCQSECHQEYLVRYCNCTMDLLFP 369
            :.:........||...|.:             .|| .|.|..|:..|....::|.|.|.|  :..
Zfish   284 LTYLPQPWGNCRSTSEQMI-------------PGYDTYSISACRLRCETLEVLRECKCRM--VHM 333

  Fly   370 PGQYRSCRAQDLLCLAEHNDLLIYSHNPGEKEFVRNQFQGMSCKCFRNCYSLNYISDVRPAFLP- 433
            ||....|...|:.|:.:...||             .:..|.:|.|...|....|..::....:|
Zfish   334 PGDANICTPSDIKCVDKALALL-------------QKSSGDTCFCETPCNLTRYGKELSMVKIPS 385

  Fly   434 -------------PDVYANNSYVDLDVHF---RFETIMVYRTSLVFGWVDLMVSFGGIAGLFLGC 482
                         .:.|..::::.||:.|   .:|||...:...|.|   |:...||..|||:|.
Zfish   386 KGSARYLSRKYDKSEDYIRDNFLVLDIFFEALNYETIEQKKAYDVAG---LLGDIGGQMGLFIGA 447

  Fly   483 SLISGMELAYFLCIEVPAFGLDGLRRRW----KARRQMDLGVTVPTPTLNFQQTTPSQLM 538
            |:::.:|:..:: .||....|:.|.|..    |..:|.....||.|..|...:...|..|
Zfish   448 SVLTILEILDYV-YEVIKHRLERLLRPQRDDKKQTQQQQQASTVATVNLEEMKAKDSSEM 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:279230	108/501 (22%)
asic4a	NP_999952.1	ASC	44..472	CDD:295594	112/516 (22%)
asic4a	NP_999952.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	474..494		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm26596
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3633
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.950