DRSC/TRiP Functional Genomics Resources

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Protein Alignment ppk7 and Scnn1g

DIOPT Version :10

Sequence 1:NP_609016.2 Gene:ppk7 / 33886 FlyBaseID:FBgn0031802 Length:573 Species:Drosophila melanogaster
Sequence 2:NP_058742.2 Gene:Scnn1g / 24768 RGDID:3641 Length:650 Species:Rattus norvegicus


Alignment Length:631 Identity:126/631 - (19%)
Similarity:210/631 - (33%) Gaps:207/631 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    42 TTIHGLDRLLSAKASRWERFVWLCTFVSAFLGAVYVCLILSARYNAAHFQTVVDSTRFPVYRIPF 106
            |..||..|::.:: .|..|.:|:...::|....::.|.:|     ...|.||..|.:....::.|
  Rat    36 TNTHGCRRIVVSR-GRLRRLLWIAFTLTAVALIIWQCALL-----VFSFYTVSVSIKVHFQKLDF 94

  Fly   107 PVITICNRNRLNWQRLA---------------------EAKSRFLANGSNSAQQ-------ELFE 143
            |.:||||.|...:..::                     |::.|..|....|..:       :|..
  Rat    95 PAVTICNINPYKYSAVSDLLTDLDSETKQALLSLYGVKESRKRREAGSMPSTLEGTPPRFFKLIP 159

  Fly   144 LIV------GTYDDAYFG----------HFQS-------------FERLRNQPTEL--------- 170
            |:|      |...|.:.|          |..|             |:...|..::.         
  Rat   160 LLVFNENEKGKARDFFTGRKRKISGKIIHKASNVMHVHESKKLVGFQLCSNDTSDCATYTFSSGI 224

  Fly   171 --------LNYVNFSQVVDF-----MTWRCNELLAECLWRHHAYDCCEIFSKRRSKNGLCWAFNS 222
                    |:|:|....|..     |::...|||..|.:...:.|............|.|:.||:
  Rat   225 NAIQEWYKLHYMNIMAQVPLEKKINMSYSAKELLVTCFFDGMSCDARNFTLFHHPMYGNCYTFNN 289

  Fly   223 LE-----------TEEGRRMQLL---DPMWPWRTGSAGPMSALSVRVLIQPAKHWP-----GHR- 267
            .|           :|.|.::.|.   |...|:...|.|      .:|||.....:|     |.. 
  Rat   290 KENATILSTSMGGSEYGLQVILYINEDEYNPFLVSSTG------AKVLIHQQNEYPFIEDVGMEI 348

  Fly   268 ETNAMKGIDVMVTEPFVWHNNPFFVAANTETTMEIEPVIYFYDNDTRGVRSDQRQCVFDDEHNSK 332
            ||.....|.:.:||.|.. :.|:  :..||...:: ||...|:                      
  Rat   349 ETAMSTSIGMHLTESFKL-SEPY--SQCTEDGSDV-PVTNIYN---------------------- 387

  Fly   333 DFKSLQGYVYMIENCQSECHQEYLVRYCNCTM--DLLFPPGQYRSCRAQDLLCLAEHNDLLIYSH 395
                   ..|.::.|...|.|..:|..|.|..  ..|.|...|         |..:.:...:|.:
  Rat   388 -------AAYSLQICLYSCFQTKMVEKCGCAQYSQPLPPAANY---------CNYQQHPNWMYCY 436

  Fly   396 NPGEKEFVRNQFQGMSCKCFRNCYSLNYISDVRPAFLPPDVYANNSYVDLDVHFRFETIMVYR-- 458
            ....:.|||.:. |....|.::|....:......|..|.:  |:..:: |:|....::..:.:  
  Rat   437 YQLYQAFVREEL-GCQSVCKQSCSFKEWTLTTSLAQWPSE--ASEKWL-LNVLTWDQSQQINKKL 497

  Fly   459 -----TSLVFGWVD----------------LMVSFGGIAGLFLGCSLISGMELAYFLCIEVPAFG 502
                 ..|:..:.|                |:.:|||..||::.||::..:|:     |||  |.
  Rat   498 NKTDLAKLLIFYKDLNQRSIMESPANSIEMLLSNFGGQLGLWMSCSVVCVIEI-----IEV--FF 555

  Fly   503 LDGL----RRRWK------ARRQMDLGVTVP---TPTLNFQQTTPS 535
            :|..    ||:|.      ||||     |.|   ||:....|..|:
  Rat   556 IDFFSIIARRQWHKAKDWWARRQ-----TPPSTETPSSRQGQDNPA 596

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ppk7NP_609016.2 ASC 38..493 CDD:459966 108/574 (19%)
Scnn1gNP_058742.2 ENaC 24..631 CDD:273304 126/631 (20%)
Gating release of inhibition by proteolysis (GRIP), protease-sensitive region that is responsible for the proteolytic activation of the channel. /evidence=ECO:0000250|UniProtKB:P51170 135..222 13/86 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 577..628 8/25 (32%)
PY motif, mediates interaction, ubiquitination and inhibition by NEDD4 and NEDD4L. /evidence=ECO:0000269|PubMed:12654927 624..628
PY motif, recruits WW domain-containing proteins and is thereby required for ubiquitination and inhibition of the channel by NEDD4 and NEDD4L. /evidence=ECO:0000250|UniProtKB:P51170 624..628
Blue background indicates that the domain is not in the aligned region.

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