DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ppk7 and Asic3

DIOPT Version :9

Sequence 1:	NP_609016.2	Gene:	ppk7 / 33886	FlyBaseID:	FBgn0031802	Length:	573	Species:	Drosophila melanogaster
Sequence 2:	XP_006535700.1	Gene:	Asic3 / 171209	MGIID:	2159339	Length:	563	Species:	Mus musculus

Alignment Length:	592	Identity:	133/592 - (22%)
Similarity:	215/592 - (36%)	Gaps:	132/592 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 PPSKLQQQQQPSRSSRLAQQLAQSSWQLALR-FGKRTTIHGLDRLLSAKASRWERFVWLCTFVSA 70
            |||.|::.|:...|.              :| |....|:|||..:.........|.:|....:.:
Mouse     3 PPSGLEEAQRRQASD--------------IRVFANSCTMHGLGHIFGPGGLTLRRGLWATAVLLS 53

  Fly    71 FLGAVYVCLILSARYNAAHFQTVVDSTRFPVYRIPFPVITICNRNRLNWQRLAEAKSRFLANGSN 135
            ....:|........|...|.:|.:|...  .:::.||.:|:||.|.|.       :||...|..:
Mouse    54 LAAFLYQVAERVRYYGEFHHKTTLDERE--SHQLTFPAVTLCNINPLR-------RSRLTPNDLH 109

  Fly   136 SAQQELFELIVGTYDDAYFGHFQSFERLRNQPTELLNYV-----NFSQVVDFMTWRCNELLAECL 195
            .|...|..|     |.|   ...::.|...||.....::     :.:|:.........::|.:|
Mouse   110 WAGTALLGL-----DPA---EHAAYLRALGQPPAPPGFMPSPTFDMAQLYARAGHSLEDMLLDC- 165

  Fly   196 WRHHAYDC-CEIFSKRRSKNGLCWAFNSLETEEGRRMQLLDPMWPWRTGSAGPMSALSVRVLIQP 259
             |:....| .|.|:...::.|.|:.|||  ..:|..: |..|     .|.||  :.|.:.:.:|.
Mouse   166 -RYRGQPCGPENFTVIFTRMGQCYTFNS--GAQGAEL-LTTP-----KGGAG--NGLEIMLDVQQ 219

  Fly   260 AKH---WPGHRETNAMKGIDVMV---TEPFVWHNNPFFVAANTETTMEIEPVIYFY------DND 312
            .::   |....||....||.|.:   .||.......|..|...:|.:..:.....:      |.:
Mouse   220 EEYLPIWKDMEETPFEVGIRVQIHGQEEPPAIDQLGFGAAPGHQTFVSCQQQQLSFLPPPWGDCN 284

  Fly   313 TRGVRSDQRQCVFDDEHNSKDFKSLQGYVYMIENCQSECHQEYLVRYCNCTMDLLFP-------P 370
            |..|..|     ||.|.:...........|.:..|:..|...|:.|.|.|.| :..|       |
Mouse   285 TASVDPD-----FDPEPSDPLGSPSSSPPYSLIGCRLACESRYVARKCGCRM-MHMPGNSPVCSP 343

  Fly   371 GQYRSCRAQDL-------LCLAEHNDLLIYSHNP-GE----------KEFVRNQFQGMSCKCFRN 417
            .||:.|.:..|       |.:..|:|:   .||| |:          ...:|..    :|.|...
Mouse   344 QQYKDCASPALGKAHLFSLPVPIHSDI---DHNPLGQVLLFLALRPADAMLRKD----TCVCPNP 401

  Fly   418 CYSLNYISDVRPAFLP--------------PDVYANNSYVDLDVHF---RFETI---MVYRTSLV 462
            |.:..|..::....:|              .:.|...:.:.||:.|   .:|.:   ..|..|
Mouse   402 CATTRYAKELSMVRIPSRASARYLARKYNRSETYITENVLVLDIFFEALNYEAVEQKAAYEVS-- 464

  Fly   463 FGWVDLMVSFGGIAGLFLGCSLISGMELAYFLCIEVPAFGLDGL--RRRWKARRQMDLGVTVPTP 525
                :|:...||..|||:|.||::.:|:..:|| ||....:.|.  .||...||.   |.|:...
Mouse   465 ----ELLGDIGGQMGLFIGASLLTILEILDYLC-EVFQDRVLGYFWNRRSSQRRS---GNTLLQE 521

  Fly   526 TLNFQQT 532
            .||..:|
Mouse   522 ELNGHRT 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:279230	112/517 (22%)
Asic3	XP_006535700.1	ASC	21..546	CDD:383197	126/560 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	108	1.000	Domainoid score	I6420
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8693
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920