Protein Alignment ppk7 and Asic1

DIOPT Version :10

• Sequence 1: NP_609016.2
• Gene: ppk7 / 33886
• FlyBaseID: FBgn0031802
• Length: 573
• Species: Drosophila melanogaster
• Sequence 2: NP_001276720.1
• Gene: Asic1 / 11419
• MGIID: 1194915
• Length: 559
• Species: Mus musculus
• Alignment Length: 590
• Identity: 132/590 - (22%)
• Similarity: 210/590 - (35%)
• Gaps: 167/590 - (28%)

  Fly     4 VYFPPSKLQQQQQPSRSSRLAQQLAQSSWQL--------ALRFGKRTTIHGLDRLLSAKASRWER 60
            ::.|....:|||..|.|....::..:|..:|        .:.|....|:||...:.........:
Mouse    24 IWGPHHHHRQQQDSSESEEEEEKEKESGMELDEGDSPRDLVAFANSCTLHGASHVFVEGGPGPRQ 88

  Fly    61 FVWLCTFVSAFLGAVYVCLI--LSARYNAAHFQTVVDSTRFPVYRIPFPVITICNRNRLNWQRLA 123
            .:|...||.| ||| ::|.:  ..|.|.:....|::|..  ....:.||.:|.||.|.:...:|:
Mouse    89 ALWAVAFVIA-LGA-FLCQVGDRVAYYLSYPHVTLLDEV--ATTELVFPAVTFCNTNAVRLSQLS 149

  Fly   124 EAKSRFLAN--GSNSAQQELFELIVGTYDDAYFGHFQSFERLRNQPTELLNYVNFSQVVDFMTWR 186
            .....:||.  |.:.:......| .....:|:.|          :|..|..:.|.|
Mouse   150 YPDLLYLAPMLGLDESDDPGVPL-APPGPEAFSG----------EPFNLHRFYNRS--------- 194

  Fly   187 CNELLAECLWRHHAYDCC--EIFSKRRSKNGLCWAFNSLETEEGR-RMQLLDPMWPWRTGSAGPM 248
            |:.|....|:..:....|  ..||...::.|.|:.|||  .::|| |:         :|...|..
Mouse   195 CHRLEDMLLYCSYCGGPCGPHNFSVVFTRYGKCYTFNS--GQDGRPRL---------KTMKGGTG 248

  Fly   249 SALSVRVLIQPAKH---WPGHRETNAMKGIDVMV----TEPFVWHNNPFFVAANTET--TMEIEP 304
            :.|.:.:.||..::   |....||:...||.|.:    ..||: ....|.||...:|  :.:.:.
Mouse   249 NGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFI-DQLGFGVAPGFQTFVSCQEQR 312

  Fly   305 VIYF-----------YDNDTRGVRSDQRQCVFDDEHNSKDFKSLQGYVYMIENCQSECHQEYLVR 358
            :||.           .|:|           .||.              |.|..|:.:|...|||.
Mouse   313 LIYLPSPWGTCNAVTMDSD-----------FFDS--------------YSITACRIDCETRYLVE 352

  Fly   359 YCNCTM-----DLLF-PPGQYRSCRAQDLLCLAEHNDLLIYSHNPGEKEFVRNQFQGMSCKCFRN 417
            .|||.|     |..: .|.||:.|....|..|.|.           ::|:         |.|...
Mouse   353 NCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEK-----------DQEY---------CVCEMP 397

  Fly   418 CYSLNYISDVRPAFLP--------------PDVYANNSYVDLDVHF---RFETIMVYRTSLVFGW 465
            |....|..::....:|              .:.|...:.:.||:.|   .:|||...:...:.|
Mouse   398 CNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAG- 461

  Fly   466 VDLMVSFGGIAGLFLGCSLISGMEL---AY-----FLCIEVPAFGLDGLRRRWKA-----RRQMD 517
              |:...||..|||:|.|:::.:||   ||     .||            ||.|.     |...|
Mouse   462 --LLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLC------------RRGKCQKEAKRNSAD 512

  Fly   518 LGVTV 522
            .||.:
Mouse   513 KGVAL 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ppk7	NP_609016.2	ASC	38..493	CDD:459966	115/512 (22%)
Asic1	NP_001276720.1	ENaC	63..541	CDD:273304	124/551 (23%)