DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpr and mtrr

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_031759354.1	Gene:	mtrr / 733716	XenbaseID:	XB-GENE-5824649	Length:	719	Species:	Xenopus tropicalis

Alignment Length:	736	Identity:	197/736 - (26%)
Similarity:	304/736 - (41%)	Gaps:	161/736 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 RSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDI-------DNSLAVF 139
            :..::.||:|.|..:..:..:.::...:   |..||        :..|||.       :....|.
Frog     7 KRFLLLYGTQQGQSKAISEEIGQQAEHH---GFTAD--------IYSLKDFKKFNLETERDPVVI 60

  Fly   140 CLATYGEGDPTDNAMEFYEWITSGD--VD-LSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGA 201
            .::|.|.|||.|.|:.|.:.|.:.:  || .:.|.|||..||:..|.::......:|.||:||||
Frog    61 VISTTGTGDPPDAAIRFLKEIQNKEHPVDYFANLKYAVLALGDSEYTYFCNGGKIIDWRLQELGA 125

  Fly   202 NRVFELGLGDDDANIEDDFITWKDRFWPAV------------CDH-------------------F 235
            ...:|.|..||...:|.....|.:..|.|:            .||                   .
Frog   126 KHFYETGYADDCVGLELVVDPWIEGLWTALHSEFIPRTEKKNTDHMKNMSTEKPATDEVPENLEL 190

  Fly   236 GIEG-GGEEVLIRQYRLLEQPDVQPDRIYTGEIARLHSIQNQ---------RPPFDA-------- 282
            .|:. ..|..::.:|.|.|....:.:|:....:....|:.:|         .|..|.
Frog   191 RIQAINLEHSVLPKYSLAENTGSESNRVIKPSLLHSGSLLSQSNLNVPVLPSPYLDVCVLESEGQ 255

  Fly   283 ----------KNPFLAPIKVNRELHKGGG-RSCMHIELSIEGSKMRYDAGDHVAMFPVND----K 332
                      :..|...|...:||..... ::.:.:||.|..:...:..||..::...|.    :
Frog   256 STDLSLLYPEEKIFNISIIQAKELTSADAVKTVLMLELDISNTSAEFQPGDSFSIICPNPHEEVE 320

  Fly   333 SLVEKL----GQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKEL 393
            .|:|||    .:.|...|.................|..|...:  ..|..|||.|:|:..:::.|
Frog   321 MLLEKLTLAEKRDCQVHLGVKLGTKKKGASVPGYIPEGCSLQF--IFTWCLEIRAVPKKAMIRAL 383

  Fly   394 AEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHV---------- 448
            .|:.::..||..|:.:.  |.:|...|..:|:|...:|:.:|....||.||::.:
Frog   384 VEHTSNAAEKRRLQELC--SKQGGSDYNHFIRDNSISILDLLNVFPSCSPPLNLLIATGNTGVKQ 446

  Fly   449 ------------CEL----------LPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKT----PTG 487
                        ||:          ||:||.|.||.:||...||..||:...:||..|    |..
Frog   447 QKISSPQKAICFCEVHIPQNPKLEHLPKLQARPYSAASSPLYHPGKVHIVFTVVELPTCPDRPAP 511

  Fly   488 RINKGVATTYL--------------KNKQPQGSEEVKVPVFIRKS-QFRLPTKPETPIIMVGPGT 537
            |  |||.|.:|              |:..|      |:.:|.|.| .|.||..|..||:||||||
Frog   512 R--KGVCTGWLAELVSHMYDTAELKKDFPP------KISIFARPSTSFHLPRDPSVPILMVGPGT 568

  Fly   538 GLAPFRGFIQERQFLRDEGK--TVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRD 599
            |:|||.||:|.|:.|:::.|  ..|::.|:||||....:|::..||..:...|.| :||..||||
Frog   569 GIAPFIGFLQHREKLKEQNKERIFGDTWLFFGCRSHENEYLFRQELRHFTDSGVLTHLKVCFSRD 633

  Fly   600 QG------KKVYVQHLLEQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEA 658
            ..      ...|||..|:..:..|..|:.:..|..|:||||||||.||.:.|..||..:.||.:.
Frog   634 PPINAGVVSPKYVQDFLKICSSDIAKVLTKENGSIYVCGDAKNMAKDVNDALANILCMELNMDKL 698

  Fly   659 DAVQYIKKMEAQKRYSADVWS 679
            :|:..:..:..||.|..||||
Frog   699 EAINTLAVLRDQKCYLQDVWS 719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	194/733 (26%)
		Flavodoxin_1	86..223	CDD:278677	41/146 (28%)
		CYPOR	281..678	CDD:99801	139/483 (29%)
mtrr	XP_031759354.1	Flavodoxin_1	11..147	CDD:395199	41/146 (28%)
mtrr	XP_031759354.1	methionine_synthase_red	272..718	CDD:99800	137/457 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53742
OrthoDB	1	1.010	-	-		D318396at2759
OrthoFinder	1	1.000	-	-		FOG0001018
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930