DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpr and nos1

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_571735.1	Gene:	nos1 / 60658	ZFINID:	ZDB-GENE-001101-1	Length:	1431	Species:	Danio rerio

Alignment Length:	693	Identity:	195/693 - (28%)
Similarity:	327/693 - (47%)	Gaps:	137/693 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVF 139
            |::||:     :.:.::||..:::|..|. |..::.....|...:|.|..:|..     .:|.:.
Zfish   753 KRVKAT-----ILFATETGKSQDYAKTLC-EIFKHAFDAKVMSMDEYDTVDLEH-----ETLVIV 806

  Fly   140 CLATYGEGDPTDNAMEF-----------------------------YEWITSGDVD--------- 166
            ..:|:|.|||.:|..:|                             |........|
Zfish   807 VTSTFGNGDPPENGEKFGAALMEMRHPTTSVEDRKTYKVRFNSVSSYSDTRKSSSDEPESKANFE 871

  Fly   167 ----LSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRF 227
                |:.:.::|||||::.|.|:...|..||...||||..|:..:|.||:....|:.|.||..:.
Zfish   872 STGPLANVRFSVFGLGSRAYPHFCAFAHAVDTLFEELGRERILRMGEGDELCGQEESFRTWAKKV 936

  Fly   228 WPAVCDHFGIEGGGEEVLIR----------------QYRL---LEQP-------DVQPDRIYTGE 266
            :.|.||.|.:   |::|.|.                ::|:   .|.|       .:...::|..:
Zfish   937 FKAACDVFCV---GDDVNIEKANDSLISNDRSWKKSKFRMTYTAEAPTLTQALYSIHKKKVYGAK 998

  Fly   267 IARLHSIQNQRPPFDAKNPFLAPIKVNRELHKGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVND 331
            :.:..::|:.|     .|.....::::...|:                .::|..|||:.:||.|:
Zfish   999 VVQRQNLQSAR-----SNRLTIFVRLDANNHE----------------SLKYLPGDHLGVFPGNN 1042

  Fly   332 K----SLVEKL------GQLCNADL----DTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEIT 382
            :    :|:|||      .|:...:.    :|...:|:..||.|:   .| |.|...|..::|:||
Zfish  1043 EDLVTTLIEKLEDAPPVNQIVKVEFLEERNTALGVISNWTDESR---IP-PCTIYQAFKYFLDIT 1103

  Fly   383 AIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDH 447
            ..|...:|::.|...|:||:::.|..::    :|.::|:.|.......:|.:||:..|.:.|...
Zfish  1104 TPPSPVLLQQFAPLATNEKQRKRLEVLS----KGLQEYEEWKWYNNPTMVEVLEEFPSLQIPSTL 1164

  Fly   448 VCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGR--INKGVATTYLKNKQPQGSEEVK 510
            :...||.|||||||||||..|:|.::|:|..:|.|:...|.  |:.||.:::| |...:|.   .
Zfish  1165 LLTQLPLLQPRYYSISSSPDLYPGEIHLTVAVVSYRPRDGEGPIHHGVCSSWL-NSLDEGD---T 1225

  Fly   511 VPVFIRKS-QFRLPTKPETPIIMVGPGTGLAPFRGFIQERQF-LRDEGKTVGESILYFGCRKRSE 573
            ||.|:|.: .||:|...:.|.|::|||||:||||.|.|:||: :.::|......||.||||:...
Zfish  1226 VPCFVRGAPSFRMPKDSQVPCILIGPGTGIAPFRAFWQQRQYDVENKGIKACPMILVFGCRQSQI 1290

  Fly   574 DYIY-ESELEEWVKKGTLNLKAAFSRDQGK-KVYVQHLL-EQDADLIWNVIGENKGHFYICGDAK 635
            |:|| |..::...|:....|..|:||:.|: |.|||.:| ||.::.::..:.|..||.|:|||.
Zfish  1291 DHIYKEQTIQAKNKEVFKELYTAYSREPGRPKKYVQDVLREQLSETVYKCLREEGGHIYVCGDV- 1354

  Fly   636 NMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVW 678
            .||.||...:.:|....||||..||..||.|:..:.||..|::
Zfish  1355 TMAGDVLKTVQQIFKLHGNMSLEDAGFYISKLRDENRYHEDIF 1397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	192/686 (28%)
		Flavodoxin_1	86..223	CDD:278677	40/178 (22%)
		CYPOR	281..678	CDD:99801	137/417 (33%)
nos1	NP_571735.1	PDZ_signaling	15..90	CDD:238492
		NOS_oxygenase_euk	302..713	CDD:238410
		CysJ	756..1396	CDD:223446	193/687 (28%)
		Flavodoxin_1	759..932	CDD:278677	40/178 (22%)
		Nitric_oxide_synthase	998..1401	CDD:99799	139/434 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910