DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpr and mtrr

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001373459.1	Gene:	mtrr / 560667	ZFINID:	ZDB-GENE-101115-3	Length:	697	Species:	Danio rerio

Alignment Length:	696	Identity:	203/696 - (29%)
Similarity:	319/696 - (45%)	Gaps:	109/696 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 VVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGDP 149
            ::.||||.|..:..|..:.::...:   |..||.......:...| |.::...||.::|.|:|||
Zfish    10 LILYGSQRGQAQSIAEEICQQAAEH---GFTADISCLSKHDKYNL-DSESRPVVFVVSTTGDGDP 70

  Fly   150 TDNAMEFYEWITSGDV---DLSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGD 211
            .|.|::|...|.:..:   .||.|.||:.|||:..|.::......:|..|::|||...:..|..|
Zfish    71 PDTALKFVRKIKNKSLPHDHLSHLRYALLGLGDTNYANFCNGGKTIDSYLQKLGAKHFYATGHAD 135

  Fly   212 DDANIEDDFITWKDRFWPAVCDHFGIEGGGE-----------------------EVLIRQYRLLE 253
            |...:|.....|.:..|.|:...|......:                       ||.::..:|.|
Zfish   136 DGTGLEVVVDPWIEGLWDALKKAFSTMSTSDQQTLSDCTQDSNHQNASDQKKNLEVDLQLLKLSE 200

  Fly   254 QPD-----VQPDRIYT--GEIARLHSIQNQRPPF------------------------------- 280
            ...     |..|.|.|  |..:.:.|::...||.
Zfish   201 VDSPKGKTVTSDSIATEIGSTSSVASLKESVPPLSESVLNVPALPPSYLEILLVGTENVEETVLP 265

  Fly   281 DAKNPFLAPIKVNRELHKGGG-RSCMHIELSI-EGSKMRYDAGDHVAMFPVNDKSLVEKLGQLCN 343
            |....|..||....:|.:... ::.:.:||.| :..:..|..||...:...|..|.||:|  |..
Zfish   266 DKDGYFEVPISKAVQLTQDDAVKTAILLELDISQQQEQVYQPGDAFDILCPNRDSEVEEL--LLK 328

  Fly   344 ADLD-----TV-FSLINTDTDSSKKHPFPCPT--TYRTALTHYLEITAIPRTHILKELAEYCTDE 400
            .||.     || .:|:...:..:.|.|...|.  :.:..||..|||.:.|:...|:.|.::..:.
Zfish   329 LDLQMQKNCTVQVNLLKNTSKKAAKVPLHIPQNGSLQFILTWCLEIRSTPKKAFLRALVDFTQNA 393

  Fly   401 KEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSS 465
            .||..|..:.  |.:|...|.|:::|:...::.:|....||.||:..:.|.||:||||.||.:||
Zfish   394 SEKRRLLELC--SKQGSADYNSFVRDSSVCVLDLLRAFPSCCPPLSLLFEHLPKLQPRAYSAASS 456

  Fly   466 AKLHPTDVHVTAVLVEYKT-PTGRINKGVAT---------------TYLKNKQPQGSEEVKVPVF 514
            :..||..||:...:||:.. |.....||:.|               |.|.:::|..|...||.|.
Zfish   457 SLQHPGKVHLVFNVVEFPARPEHPARKGLCTGWLVDHVSSILEPHGTALASERPGTSALPKVHVR 521

  Fly   515 IR-KSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGK--TVGESILYFGCRKRSEDYI 576
            .| .|.|.||:.|..|::|||||||:|||.||:|:|:..|:..:  |.||..|:||||.:.:|::
Zfish   522 ARPSSTFHLPSDPCVPVVMVGPGTGVAPFIGFLQQREKEREANQEATFGEMWLFFGCRHKDKDFL 586

  Fly   577 YESELEEWVKKGTL-NLKAAFSRDQ-------GKKVYVQHLLEQDADLIWNVIGENKGHFYICGD 633
            :..|||::|..||| :|...||||:       .:..||||.|...|..:..::.|:||..|:|||
Zfish   587 FREELEKFVHNGTLSHLIVCFSRDEPDAAETVNRPTYVQHNLILHAKNLAKILLEDKGCLYVCGD 651

  Fly   634 AKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVWS 679
            |||||.||.:.|::|:..:..:.:.||::.:..:...|||..|:||
Zfish   652 AKNMAKDVNDTLLEIIGNELQLDKLDAMKIVAGLREDKRYLQDIWS 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	201/693 (29%)
		Flavodoxin_1	86..223	CDD:278677	40/139 (29%)
		CYPOR	281..678	CDD:99801	145/433 (33%)
mtrr	NP_001373459.1	Flavodoxin_1	11..147	CDD:395199	40/139 (29%)
mtrr	NP_001373459.1	methionine_synthase_red	274..696	CDD:99800	143/425 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53742
OrthoDB	1	1.010	-	-		D318396at2759
OrthoFinder	1	1.000	-	-		FOG0001018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.830