DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpr and NOS3

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_000594.2	Gene:	NOS3 / 4846	HGNCID:	7876	Length:	1203	Species:	Homo sapiens

Alignment Length:	721	Identity:	201/721 - (27%)
Similarity:	323/721 - (44%)	Gaps:	138/721 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SRKKE-EEPTRSYSIQPTTVCTTSASDNSFIKKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIR 108
            :|||. :|...:..|..:.:.|..|      |::||:     :.|||:||..:.:|.:|.
Human   491 TRKKTFKEVANAVKISASLMGTVMA------KRVKAT-----ILYGSETGRAQSYAQQLG----- 539

  Fly   109 YRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGDPTDNAMEF----------------- 156
             ||.....||....|:|...:.....:|.:...:|:|.|||.:|...|
Human   540 -RLFRKAFDPRVLCMDEYDVVSLEHETLVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRP 603

  Fly   157 -----YE---------------W----ITSGDVDLSG----LNYAVFGLGNKTYEHYNKVAIYVD 193
                 |:               |    ..|.:.|.:|    |.:.|||||::.|.|:...|..||
Human   604 EQHKSYKIRFNSISCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVD 668

  Fly   194 KRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLI------------ 246
            .||||||..|:.:||.||:....|:.|..|....:.|.|:.|.:   ||:...
Human   669 TRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCV---GEDAKAAARDIFSPKRSW 730

  Fly   247 --RQYRLLEQPD----------VQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELHKG 299
              ::|||..|.:          |...:::...|..:.::|:.:
Human   731 KRQRYRLSAQAEGLQLLPGLIHVHRRKMFQATIRSVENLQSSK---------------------- 773

  Fly   300 GGRSCMHIELSIEGSK-MRYDAGDHVAMFPVNDKSLVEK-LGQLCNADLDTVFSLINTDTDSSKK 362
            ..|:.:.:.|...|.: ::|..|||:.:.|.|...|||. |.::.:....|....:......|..
Human   774 STRATILVRLDTGGQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPAPTEPVAVEQLEKGSPG 838

  Fly   363 HPFP--------CPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEK 419
            .|.|        .|.|.|.|||.:|:||:.|...:|:.|:....:.:|::.|.:::    :...:
Human   839 GPPPGWVRDPRLPPCTLRQALTFFLDITSPPSPQLLRLLSTLAEEPREQQELEALS----QDPRR 899

  Fly   420 YQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKT 484
            |:.|....|..::.:||...|...|...:...||.|||||||:||:...||.::|:|..::.|:|
Human   900 YEEWKWFRCPTLLEVLEQFPSVALPAPLLLTQLPLLQPRYYSVSSAPSTHPGEIHLTVAVLAYRT 964

  Fly   485 P--TGRINKGVATTYLKNKQPQGSEEVKVPVFIRKS-QFRLPTKPETPIIMVGPGTGLAPFRGFI 546
            .  .|.::.||.:|:|...:|..    .||.|||.: .||||..|..|.|:||||||:||||||.
Human   965 QDGLGPLHYGVCSTWLSQLKPGD----PVPCFIRGAPSFRLPPDPSLPCILVGPGTGIAPFRGFW 1025

  Fly   547 QER-QFLRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRD-QGKKVYVQH 608
            ||| ..:..:|.......|.||||....|::|..|::...::|.. .:..||||: ...|.|||.
Human  1026 QERLHDIESKGLQPTPMTLVFGCRCSQLDHLYRDEVQNAQQRGVFGRVLTAFSREPDNPKTYVQD 1090

  Fly   609 LLEQD-ADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKR 672
            :|..: |..:..|:...:||.::|||. .||.:|...:.:||:|:|:|...:|...|..:..|:|
Human  1091 ILRTELAAEVHRVLCLERGHMFVCGDV-TMATNVLQTVQRILATEGDMELDEAGDVIGVLRDQQR 1154

  Fly   673 YSADVW 678
            |..|::
Human  1155 YHEDIF 1160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	191/683 (28%)
		Flavodoxin_1	86..223	CDD:278677	50/181 (28%)
		CYPOR	281..678	CDD:99801	128/413 (31%)
NOS3	NP_000594.2	Flavodoxin_1	522..698	CDD:306716	50/181 (28%)
		FNR_like	762..1164	CDD:323647	130/430 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71
		NOS_oxygenase_euk	68..480	CDD:238410
		Interaction with NOSIP. /evidence=ECO:0000269\|PubMed:11149895	98..486
		Calmodulin-binding. /evidence=ECO:0000255	491..510		5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810