DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpr and NOS2

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_000616.3	Gene:	NOS2 / 4843	HGNCID:	7873	Length:	1153	Species:	Homo sapiens

Alignment Length:	653	Identity:	205/653 - (31%)
Similarity:	321/653 - (49%)	Gaps:	101/653 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 IKKLKASGRSLVVFYGSQTGTGEEFA---GRLAKEGI--------RYRLKGMVADPEECDMEELL 127
            ::|..||...:.:.:.::||..|..|   |.|.....        :|||        .|..||.|
Human   529 MRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRL--------SCLEEERL 585

  Fly   128 QLKDIDNSLAVFCLATYGEGDPTDNAMEFYEWITSGDVDLSGLN----YAVFGLGNKTYEHYNKV 188
            .|         ...:|:|.||...|.    |.:......|..||    |||||||:..|..:...
Human   586 LL---------VVTSTFGNGDCPGNG----EKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAF 637

  Fly   189 AIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLIRQYRLLE 253
            |..:|::|..|||:::..:|.||:.:..||.|.:|..:.:.|.|:.|.:.|       :|:
Human   638 AHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRG-------KQH---- 691

  Fly   254 QPDVQPDRIYTGEIA------RLHSIQNQRP--------PFDAKNPFLAPIKVNRELHK-GGGRS 303
               :|..::||..:.      ||  :|:.:|        ...|||.|...:|..:.|.. ...|:
Human   692 ---IQIPKLYTSNVTWDPHHYRL--VQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRA 751

  Fly   304 CMHIELSIE-GSKMRYDAGDHVAMFPVNDKSLVEKLGQLCNADLDTVFSLINTDT--------DS 359
            .:.:|||.| |..:.|..|:|:.:.|.|..:||:.:.:.. .|..|....:..:.        .|
Human   752 TILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERV-VDGPTPHQTVRLEALDESGSYWVS 815

  Fly   360 SKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWI 424
            .|:.| ||  :...|||::|:||..|...:|::||:..|:|.|::.|.::...|     :|..|.
Human   816 DKRLP-PC--SLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQPS-----EYSKWK 872

  Fly   425 QDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGR- 488
            .......:.:||:..|.|.....:...||.|:||:||||||....||::|:|..:|.|.|..|:
Human   873 FTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQG 937

  Fly   489 -INKGVATTYLKNKQPQGSEEVKVPVFIRK-SQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQF 551
             ::.||.:|:|.:.:||.    .||.|:|. |.|.||..|..|.|::|||||:||||.|.|:|
Human   938 PLHHGVCSTWLNSLKPQD----PVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQR-- 996

  Fly   552 LRD---EGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTLN-LKAAFSRDQGK-KVYVQHLLE 611
            |.|   :|...|...|.||||:..||:||:.|:.|..:||.|: :..|:||..|| |||||.:|.
Human   997 LHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILR 1061

  Fly   612 QD-ADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSA 675
            |. |..:..|:.:..||.|:|||.: ||.||.:.|.::::.|..::|.....|..::::||||..
Human  1062 QQLASEVLRVLHKEPGHLYVCGDVR-MARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHE 1125

  Fly   676 DVW 678
            |::
Human  1126 DIF 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	203/645 (31%)
		Flavodoxin_1	86..223	CDD:278677	43/151 (28%)
		CYPOR	281..678	CDD:99801	146/415 (35%)
NOS2	NP_000616.3	DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000269\|PubMed:21199876	23..27
		NOS_oxygenase_euk	84..496	CDD:238410
		Calmodulin-binding. /evidence=ECO:0000255	509..529		205/653 (31%)
		CysJ	538..1127	CDD:223446	201/641 (31%)
		Flavodoxin_1	541..672	CDD:278677	43/151 (28%)
		FNR_like	736..1132	CDD:297884	142/409 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810