Protein Alignment Cpr and NOS1

DIOPT Version :10

• Sequence 1: NP_477158.1
• Gene: Cpr / 33883
• FlyBaseID: FBgn0015623
• Length: 679
• Species: Drosophila melanogaster
• Sequence 2: NP_001191147.1
• Gene: NOS1 / 4842
• HGNCID: 7872
• Length: 1468
• Species: Homo sapiens
• Alignment Length: 728
• Identity: 212/728 - (29%)
• Similarity: 326/728 - (44%)
• Gaps: 173/728 - (23%)

  Fly    75 KKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVF 139
            |::||:     :.|.::||..:.:|..|. |..::.....|...||.|:..|..     .:|.:.
Human   756 KRVKAT-----ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEH-----ETLVLV 809

  Fly   140 CLATYGEGDPTDNAMEF------------------YEW-----------ITSGDVDLSGL----- 170
            ..:|:|.|||.:|..:|                  |..           :.:||.::.||
Human   810 VTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKYPEPLRFFPRKGPPLPNGDTEVHGLAAARD 874

  Fly   171 ------------------------------------------NYAVFGLGNKTYEHYNKVAIYVD 193
                                                      .::|||||::.|.|:......||
Human   875 SQHRSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVD 939

  Fly   194 KRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLI------------ 246
            ..|||||..|:.::..||:....|:.|.||..:.:.|.||.|.:   |::|.|
Human   940 TLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCV---GDDVNIEKANNSLISNDR 1001

  Fly   247 ----RQYRL---LEQPD-------VQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELH 297
                .::||   .|.|:       |...|:   ..|||.|.||.:.|
Human  1002 SWKRNKFRLTFVAEAPELTQGLSNVHKKRV---SAARLLSRQNLQSP------------------ 1045

  Fly   298 KGGGRSCMHIELSIEGS-KMRYDAGDHVAMFPVNDKSLVEKL----------GQLCNADL----D 347
             ...||.:.:.|...|| :::|..|||:.:||.|.:.||..|          .|:...:|    :
Human  1046 -KSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERN 1109

  Fly   348 TVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASI 412
            |...:|:..||..:   .| |.|...|..:||:||..|....|::.|...|.||||:.|..::
Human  1110 TALGVISNWTDELR---LP-PCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLS-- 1168

  Fly   413 SPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTA 477
              :|.::|:.|.......||.:||:..|.:.|...:...|..|||||||||||..::|.:||:|.
Human  1169 --KGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTV 1231

  Fly   478 VLVEYKTPTGR--INKGVATTYLKNKQPQGSEEVKVPVFIRKS-QFRLPTKPETPIIMVGPGTGL 539
            .:|.|:|..|.  |:.||.:::|...|   ::|: ||.|:|.: .|.||..|:.|.|:||||||:
Human  1232 AIVSYRTRDGEGPIHHGVCSSWLNRIQ---ADEL-VPCFVRGAPSFHLPRNPQVPCILVGPGTGI 1292

  Fly   540 APFRGFIQERQF-LRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGK 602
            ||||.|.|:||| ::.:|......:|.||||:...|:||..|..:...||.. .|..|:||:..|
Human  1293 APFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDK 1357

  Fly   603 -KVYVQHLL-EQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIK 665
             |.|||.:| ||.|:.::..:.|..||.|:|||. .||.||...:.:|::.:|.:|..||..:|.
Human  1358 PKKYVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFIS 1421

  Fly   666 KMEAQKRYSADVW 678
            :|....||..|::
Human  1422 RMRDDNRYHEDIF 1434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_477158.1	Flavodoxin_1	86..223	CDD:425562	43/212 (20%)
		CYPOR	281..678	CDD:99801	144/418 (34%)
NOS1	NP_001191147.1	PDZ_nNOS-like	14..123	CDD:467192
		NOS_oxygenase_euk	305..716	CDD:238410
		Flavodoxin_1	762..969	CDD:425562	43/212 (20%)
		Nitric_oxide_synthase	1035..1438	CDD:99799	150/432 (35%)