DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpr and NOS1

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001191147.1	Gene:	NOS1 / 4842	HGNCID:	7872	Length:	1468	Species:	Homo sapiens

Alignment Length:	728	Identity:	212/728 - (29%)
Similarity:	326/728 - (44%)	Gaps:	173/728 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVF 139
            |::||:     :.|.::||..:.:|..|. |..::.....|...||.|:..|..     .:|.:.
Human   756 KRVKAT-----ILYATETGKSQAYAKTLC-EIFKHAFDAKVMSMEEYDIVHLEH-----ETLVLV 809

  Fly   140 CLATYGEGDPTDNAMEF------------------YEW-----------ITSGDVDLSGL----- 170
            ..:|:|.|||.:|..:|                  |..           :.:||.::.||
Human   810 VTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKYPEPLRFFPRKGPPLPNGDTEVHGLAAARD 874

  Fly   171 ------------------------------------------NYAVFGLGNKTYEHYNKVAIYVD 193
                                                      .::|||||::.|.|:......||
Human   875 SQHRSYKVRFNSVSSYSDSQKSSGDGPDLRDNFESAGPLANVRFSVFGLGSRAYPHFCAFGHAVD 939

  Fly   194 KRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLI------------ 246
            ..|||||..|:.::..||:....|:.|.||..:.:.|.||.|.:   |::|.|
Human   940 TLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCV---GDDVNIEKANNSLISNDR 1001

  Fly   247 ----RQYRL---LEQPD-------VQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELH 297
                .::||   .|.|:       |...|:   ..|||.|.||.:.|
Human  1002 SWKRNKFRLTFVAEAPELTQGLSNVHKKRV---SAARLLSRQNLQSP------------------ 1045

  Fly   298 KGGGRSCMHIELSIEGS-KMRYDAGDHVAMFPVNDKSLVEKL----------GQLCNADL----D 347
             ...||.:.:.|...|| :::|..|||:.:||.|.:.||..|          .|:...:|    :
Human  1046 -KSSRSTIFVRLHTNGSQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPVNQMVKVELLEERN 1109

  Fly   348 TVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASI 412
            |...:|:..||..:   .| |.|...|..:||:||..|....|::.|...|.||||:.|..::
Human  1110 TALGVISNWTDELR---LP-PCTIFQAFKYYLDITTPPTPLQLQQFASLATSEKEKQRLLVLS-- 1168

  Fly   413 SPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTA 477
              :|.::|:.|.......||.:||:..|.:.|...:...|..|||||||||||..::|.:||:|.
Human  1169 --KGLQEYEEWKWGKNPTIVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTV 1231

  Fly   478 VLVEYKTPTGR--INKGVATTYLKNKQPQGSEEVKVPVFIRKS-QFRLPTKPETPIIMVGPGTGL 539
            .:|.|:|..|.  |:.||.:::|...|   ::|: ||.|:|.: .|.||..|:.|.|:||||||:
Human  1232 AIVSYRTRDGEGPIHHGVCSSWLNRIQ---ADEL-VPCFVRGAPSFHLPRNPQVPCILVGPGTGI 1292

  Fly   540 APFRGFIQERQF-LRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGK 602
            ||||.|.|:||| ::.:|......:|.||||:...|:||..|..:...||.. .|..|:||:..|
Human  1293 APFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDK 1357

  Fly   603 -KVYVQHLL-EQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIK 665
             |.|||.:| ||.|:.::..:.|..||.|:|||. .||.||...:.:|::.:|.:|..||..:|.
Human  1358 PKKYVQDILQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSAEDAGVFIS 1421

  Fly   666 KMEAQKRYSADVW 678
            :|....||..|::
Human  1422 RMRDDNRYHEDIF 1434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	209/721 (29%)
		Flavodoxin_1	86..223	CDD:278677	43/212 (20%)
		CYPOR	281..678	CDD:99801	144/418 (34%)
NOS1	NP_001191147.1	PDZ_signaling	15..98	CDD:238492
		NOS_oxygenase_euk	305..716	CDD:238410
		CysJ	759..1433	CDD:223446	210/722 (29%)
		Flavodoxin_1	762..969	CDD:278677	43/212 (20%)
		Nitric_oxide_synthase	1035..1438	CDD:99799	150/432 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810