DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpr and MTRR

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001351369.1	Gene:	MTRR / 4552	HGNCID:	7473	Length:	698	Species:	Homo sapiens

Alignment Length:	703	Identity:	199/703 - (28%)
Similarity:	319/703 - (45%)	Gaps:	111/703 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 RSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGE 146
            |..::.|.:|.|..:..|..:.::.:   :.|..||.......:...|| .:.:..|..::|.|.
Human     2 RRFLLLYATQQGQAKAIAEEICEQAV---VHGFSADLHCISESDKYDLK-TETAPLVVVVSTTGT 62

  Fly   147 GDPTDNAMEFYEWITSGDVDL---SGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELG 208
            |||.|.|.:|.:.|.:..:.:   :.|.|.:.|||:..|.::......:||||:||||...::.|
Human    63 GDPPDTARKFVKEIQNQTLPVDFFAHLRYGLLGLGDSEYTYFCNGGKIIDKRLQELGARHFYDTG 127

  Fly   209 LGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEV---------------LIRQYRLLEQPDVQ 258
            ..||...:|.....|....|||:..||....|.||:               |::...|..:..|:
Human   128 HADDCVGLELVVEPWIAGLWPALRKHFRSSRGQEEISGALPVASPASSRTDLVKSELLHIESQVE 192

  Fly   259 PDRI-----YTGEIARLHSIQNQR----------------PPFDAKN---PFLAPIKVNRELHKG 299
            ..|.     ...|:.:.:::.:.:                ||....:   |.|.|..:...|.:.
Human   193 LLRFDDSGRKDSEVLKQNAVNSNQSNVVIEDFESSLTRSVPPLSQASLNIPGLPPEYLQVHLQES 257

  Fly   300 GG-------------------------------RSCMHIELSIEGSKMRYDAGDHVAMFPVNDKS 333
            .|                               ::.:.:||.|..:...|..||..::...|..|
Human   258 LGQEESQVSVTSADPVFQVPISKAVQLTTNDAIKTTLLVELDISNTDFSYQPGDAFSVICPNSDS 322

  Fly   334 LVEKLGQ-LCNADLDTVFSLINTDTDSSKK-----HPFPCPTTYRTALTHYLEITAIPRTHILKE 392
            .|:.|.| |...|......|:....|:.||     ...|...:.:...|..|||.|||:...|:.
Human   323 EVQSLLQRLQLEDKREHCVLLKIKADTKKKGATLPQHIPAGCSLQFIFTWCLEIRAIPKKAFLRA 387

  Fly   393 LAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQP 457
            |.:|.:|..||..|:.:.  |.:|...|..:::|||..::.:|....||:||:..:.|.||:|||
Human   388 LVDYTSDSAEKRRLQELC--SKQGAADYSRFVRDACACLLDLLLAFPSCQPPLSLLLEHLPKLQP 450

  Fly   458 RYYSISSSAKLHPTDVHVTAVLVEY-KTPTGRI-NKGVATTYL-----KNKQP--QGSEE----- 508
            |.||.:||:..||..:|....:||: .|.|..: .|||.|.:|     ...||  ..|.|
Human   451 RPYSCASSSLFHPGKLHFVFNIVEFLSTATTEVLRKGVCTGWLALLVASVLQPNIHASHEDSGKA 515

  Fly   509 --VKVPVFIR-KSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDE--GKTVGESILYFGC 568
              .|:.:..| .:.|.||..|..||||||||||:|||.||:|.|:.|:::  ....|...|:|||
Human   516 LAPKISISPRTTNSFHLPDDPSIPIIMVGPGTGIAPFIGFLQHREKLQEQHPDGNFGAMWLFFGC 580

  Fly   569 RKRSEDYIYESELEEWVKKGTL-NLKAAFSRD------QGKKVYVQHLLEQDADLIWNVIGENKG 626
            |.:..||::..||..::|.|.| :||.:||||      :....|||..::.....:..::.:..|
Human   581 RHKDRDYLFRKELRHFLKHGILTHLKVSFSRDAPVGEEEAPAKYVQDNIQLHGQQVARILLQENG 645

  Fly   627 HFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVWS 679
            |.|:||||||||.||.:.||:|:|.:..:.:.:|::.:..::.:|||..|:||
Human   646 HIYVCGDAKNMAKDVHDALVQIISKEVGVEKLEAMKTLATLKEEKRYLQDIWS 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	197/700 (28%)
		Flavodoxin_1	86..223	CDD:278677	37/139 (27%)
		CYPOR	281..678	CDD:99801	143/462 (31%)
MTRR	NP_001351369.1	Flavodoxin_1	6..142	CDD:306716	37/139 (27%)
		Hinge	166..247		9/80 (11%)
		methionine_synthase_red	277..697	CDD:99800	138/421 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53742
OrthoDB	1	1.010	-	-		D318396at2759
OrthoFinder	1	1.000	-	-		FOG0001018
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830