DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpr and Ndor1

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_001101288.1	Gene:	Ndor1 / 311799	RGDID:	1308479	Length:	598	Species:	Rattus norvegicus

Alignment Length:	621	Identity:	194/621 - (31%)
Similarity:	311/621 - (50%)	Gaps:	53/621 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 LVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGD 148
            |:|.:||||||.::.|.||.:|..|.||...|...:...:..|::     ..|.:|..||.|:||
  Rat     6 LLVLFGSQTGTAQDEAERLGREARRRRLGCRVQALDSYSVANLIR-----EPLVIFVCATTGQGD 65

  Fly   149 PTDNAMEFYEWI---TSGDVDLSGLNYAVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLG 210
            |.||...|:.:|   :.....|..:::||.|||:.:|..:|.||..:.:||.:||.|.:....||
  Rat    66 PPDNMKNFWRFIFRKSLPSTSLCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGNALVPPCLG 130

  Fly   211 DD------DANIEDDFITWKDRFWPAVCDHFGIEGGGEEV---------LIRQYRLLEQPDVQPD 260
            ||      ||.|:    .|....|..:...:.:.....|:         .|.|: |.|.|.:..:
  Rat   131 DDQHELGPDAAID----PWVGDLWEKIMTMYPVPLDIPEIPHGVPLPSKFIFQF-LQEVPSIGAE 190

  Fly   261 RIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNREL----HKGGGRSCMHIELSIEGSKMRYDAG 321
            .:      .|.|...|.||.:.: |||||:..|:.:    |....|.   :|..|..|.:.:.||
  Rat   191 EL------NLASSAPQTPPSELQ-PFLAPVVTNQRVTGPQHFQDVRL---MEFDITESNISFAAG 245

  Fly   322 DHVAMFPVNDKSLVEKLGQLCNADLDTVFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPR 386
            |.|.:.|.|.::..::..||...|.:..|:|...:.........|...|....::.||:|.::||
  Rat   246 DVVLILPSNSEAHTKQFCQLLCLDPNQFFTLKPREPGVPYPPGLPQHCTVWHLVSQYLDIASVPR 310

  Fly   387 THILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDI---KSCRPPIDHV 448
            ....:.||.......|:|.|...:  |..|:|:...:.....|.|:.:|.|.   ....|| |::
  Rat   311 RSFFELLACLSPHALEREKLLEFS--SARGQEELWEYCNRPRRTILEVLCDFPHTAGAIPP-DYL 372

  Fly   449 CELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGRINKGVATTYLKNKQPQGSEEVKVPV 513
            .:|:||::||.:||:||...||..:.:...:|:|:|......:|:.:::|.:..|..:..|:||:
  Rat   373 LDLIPRIRPRAFSIASSLLAHPRRLQILVAVVKYQTRLKEPRRGLCSSWLASLTPGQAGPVRVPL 437

  Fly   514 FIRKSQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRDEGKTVGESILYFGCRKRSEDYIYE 578
            ::|......|..|.|||||||||||:||||..||||......|     ::|:||||:|.:|:.::
  Rat   438 WVRPGSLVFPKTPGTPIIMVGPGTGVAPFRAAIQERVAHGQMG-----NVLFFGCRQRDQDFYWQ 497

  Fly   579 SELEEWVKKGTLNLKAAFSRDQGKKVYVQHLLEQDADLIWNVIGENKGHFYICGDAKNMAVDVRN 643
            :|.:|..::|.|.|..||||:|.:||||||.|.:...|:|.::.....:||:.|:||.|..||..
  Rat   498 TEWQELEQRGCLTLVTAFSREQAQKVYVQHRLRELGPLVWELLDGQGAYFYLAGNAKYMPTDVSE 562

  Fly   644 ILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVWS 679
            .|..|...:|.:|..||..|:.:::...|:..:.|:
  Rat   563 ALTAIFQEEGRLSTTDAAAYLARLQQTLRFQTETWA 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	193/618 (31%)
		Flavodoxin_1	86..223	CDD:278677	50/145 (34%)
		CYPOR	281..678	CDD:99801	129/403 (32%)
Ndor1	NP_001101288.1	CysJ	6..597	CDD:223446	193/618 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53742
OrthoDB	1	1.010	-	-		D318396at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830