DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpr and Nos3

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_068610.1	Gene:	Nos3 / 24600	RGDID:	3186	Length:	1202	Species:	Rattus norvegicus

Alignment Length:	739	Identity:	207/739 - (28%)
Similarity:	324/739 - (43%)	Gaps:	174/739 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SRKKE-EEPTRSYSIQPTTVCTTSASDNSFIKKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIR 108
            :|||. :|...:..|..:.:.|..|      |::||:     :.|||:||..:.:|.:|.
  Rat   490 TRKKTFKEVANAVKISASLMGTVMA------KRVKAT-----ILYGSETGRAQSYAQQLG----- 538

  Fly   109 YRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGDPTDNAMEF----------------- 156
             ||.....||....|:|...:.....:|.:...:|:|.|||.:|...|
  Rat   539 -RLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRP 602

  Fly   157 -----YE---------------W----ITSGDVDLSG----LNYAVFGLGNKTYEHYNKVAIYVD 193
                 |:               |    ..|.:.|.:|    |.:.|||||::.|.|:...|..||
  Rat   603 EQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVD 667

  Fly   194 KRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLI------------ 246
            .||||||..|:.:||.||:....|:.|..|....:.|.|:.|.:   ||:...
  Rat   668 TRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCV---GEDAKAAARDIFSPKRSW 729

  Fly   247 --RQYRLLEQPD----------VQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELHKG 299
              ::|||..|.:          |...:::...|..:.::|:.:
  Rat   730 KRQRYRLSTQAESLQLLPGLTHVHRRKMFQATILSVENLQSSK---------------------- 772

  Fly   300 GGRSCMHIEL---SIEGSKMRYDAGDHVAMFPVNDKSLVEKLGQLCNADLDTVFSLINTDTDSSK 361
            ..|:.:.:.|   |.||  ::|..|||:.:.|.|...|||.|           .|.:.....|::
  Rat   773 STRATILVRLDTGSQEG--LQYQPGDHIGVCPPNRPGLVEAL-----------LSRVEDPPPSTE 824

  Fly   362 --------------------KHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELL 406
                                :.|...|.|.|.|||::|:||:.|...:|:.|:....:..|::.|
  Rat   825 PVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQEL 889

  Fly   407 RSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPT 471
            .:::    :...:|:.|....|..::.:||...|...|...:...||.|||||||:||:...||.
  Rat   890 EALS----QDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPG 950

  Fly   472 DVHVTAVLVEYKTP--TGRINKGVATTY---LKNKQPQGSEEVKVPVFIRKS-QFRLPTKPETPI 530
            ::|:|..::.|:|.  .|.::.||.:|:   ||...|       ||.|||.: .||||..|..|.
  Rat   951 EIHLTVAVLAYRTQDVLGPLHYGVCSTWMSQLKAGDP-------VPCFIRGAPSFRLPPDPNLPC 1008

  Fly   531 IMVGPGTGLAPFRGFIQERQFLRD---EGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-N 591
            |:||||||:||||||.|:|  |.|   :|.......|.||||....|::|..|:.:..::|.. .
  Rat  1009 ILVGPGTGIAPFRGFWQDR--LHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQ 1071

  Fly   592 LKAAFSRDQGK-KVYVQHLLEQD-ADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGN 654
            :..|||||.|. |.|||.||..: |..:..|:...:||.::|||. .||..|...:.:||:|:|:
  Rat  1072 VLTAFSRDPGSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDV-TMATSVLQTVQRILATEGS 1135

  Fly   655 MSEADAVQYIKKMEAQKRYSADVW 678
            |...:|...|..:..|:||..|::
  Rat  1136 MELDEAGDVIGVLRDQQRYHEDIF 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	197/701 (28%)
		Flavodoxin_1	86..223	CDD:278677	50/181 (28%)
		CYPOR	281..678	CDD:99801	134/431 (31%)
Nos3	NP_068610.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..70
		FLO_LFY	30..>61	CDD:279962
		NOS_oxygenase_euk	67..479	CDD:238410
		Interaction with NOSIP. /evidence=ECO:0000250	97..485
		Calmodulin-binding. /evidence=ECO:0000255	489..509		5/18 (28%)
		CysJ	511..1158	CDD:223446	201/715 (28%)
		Flavodoxin_1	521..697	CDD:278677	50/181 (28%)
		FNR_like	761..1163	CDD:297884	136/448 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	817..843		1/25 (4%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810