DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpr and Nos2

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_036743.3	Gene:	Nos2 / 24599	RGDID:	3185	Length:	1147	Species:	Rattus norvegicus

Alignment Length:	677	Identity:	203/677 - (29%)
Similarity:	333/677 - (49%)	Gaps:	95/677 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 LRSRKKEEEPTRSYSIQPTTVCTTSASDNSFIKKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGI 107
            ||.|::|        |:.|.:.......:..::|:.||.....|.:.::||..|..|..||.. .
  Rat   503 LRPRRRE--------IRFTVLVKAVFFASVLMRKVMASRVRATVLFATETGKSEALARDLAAL-F 558

  Fly   108 RYRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGDPTDNAMEFYEWITSGDVDLSGLNY 172
            .|.....|...|:.....|     .:..|.:...:|:|.||...|.....:.:...........|
  Rat   559 SYAFNTKVVCMEQYKANTL-----EEEQLLLVVTSTFGNGDCPSNGQTLKKSLFMMKELGHTFRY 618

  Fly   173 AVFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGI 237
            ||||||:..|..:...|..:|::|..|||:::...|.||:.:..||.|.:|..:.:.|.|:.|.:
  Rat   619 AVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFDV 683

  Fly   238 EGGGEEVLIR--------------QYRLLEQPD----------VQPDRIYTGEIARLHSIQNQRP 278
            .   .:..|:              ||:|.:.|:          :....::|..:..|.::|:::
  Rat   684 R---SKHCIQIPKRYTSNATWEPEQYKLTQSPESLDLNKALSSIHAKNVFTMRLKSLQNLQSEK- 744

  Fly   279 PFDAKNPFLAPIKVNRELHKGGGRSCMHIELSIEGSK-MRYDAGDHVAMFPVNDKSLVEKLGQL- 341
                                 ..|:.:.::|:.|||: ..|..|:|:.:||.|..:||:.:.:.
  Rat   745 ---------------------SSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQGILERV 788

  Fly   342 --CNADLDTVFSLINTDTDS----SKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDE 400
              |::...||...:..::.|    .|:.| ||  :.|.|||::|:||..|....|.:||.:.|:|
  Rat   789 VDCSSPDQTVCLEVLDESGSYWVKDKRLP-PC--SLRQALTYFLDITTPPTQLQLHKLARFATEE 850

  Fly   401 KEKELLRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSS 465
            ..::.|.::...|     :|..|........:.:||:..|.|.|...:...||.|:|||||||||
  Rat   851 THRQRLEALCQPS-----EYNDWKFSNNPTFLEVLEEFPSLRVPAAFLLLQLPILKPRYYSISSS 910

  Fly   466 AKLHPTDVHVTAVLVEYKTPTGR--INKGVATTYLKNKQPQGSEEVKVPVFIRK-SQFRLPTKPE 527
            ....|::||:|..:|.|:|..|:  ::.||.:|::.|.:|    |..||.|:|. |.|:||..|.
  Rat   911 QDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWINNLKP----EDPVPCFVRSVSGFQLPEDPS 971

  Fly   528 TPIIMVGPGTGLAPFRGFIQERQFLRD---EGKTVGESILYFGCRKRSEDYIYESELEEWVKKGT 589
            .|.|::|||||:||||.|.|:|  |.|   .|...|...|.||||...||::|:.|::|.|:||.
  Rat   972 QPCILIGPGTGIAPFRSFWQQR--LHDSQHRGLKGGRMTLVFGCRHPEEDHLYQEEMQEMVRKGV 1034

  Fly   590 L-NLKAAFSRDQGK-KVYVQHLLEQD-ADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILST 651
            | .:...:||..|| |||||.:|::: ||.:::|:...:||.|:|||.: ||.||...|.|:::.
  Rat  1035 LFQVHTGYSRLPGKPKVYVQDILQKELADEVFSVLHGEQGHLYVCGDVR-MARDVATTLKKLVAA 1098

  Fly   652 KGNMSEADAVQYIKKMEAQKRYSADVW 678
            |.|:||.....|..::::||||..|::
  Rat  1099 KLNLSEEQVEDYFFQLKSQKRYHEDIF 1125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	195/638 (31%)
		Flavodoxin_1	86..223	CDD:278677	37/136 (27%)
		CYPOR	281..678	CDD:99801	145/413 (35%)
Nos2	NP_036743.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..51
		DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000250\|UniProtKB:P35228	23..27
		NOS_oxygenase_euk	81..493	CDD:238410
		Calmodulin-binding. /evidence=ECO:0000255	506..526		4/27 (15%)
		CysJ	537..1124	CDD:223446	193/632 (31%)
		Flavodoxin_1	538..669	CDD:278677	37/136 (27%)
		FNR_like	733..1129	CDD:297884	147/430 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810