DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpr and Nos1

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_038944987.1	Gene:	Nos1 / 24598	RGDID:	3184	Length:	1532	Species:	Rattus norvegicus

Alignment Length:	727	Identity:	205/727 - (28%)
Similarity:	327/727 - (44%)	Gaps:	171/727 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIRYRLKGMVADPEECDMEELLQLKDIDNSLAVF 139
            |::||:     :.|.::||..:.:|..|. |..::.........||.|:..|..     .:|.:.
  Rat   751 KRVKAT-----ILYATETGKSQAYAKTLC-EIFKHAFDAKAMSMEEYDIVHLEH-----EALVLV 804

  Fly   140 CLATYGEGDPTDNAMEF------------------------------------------------ 156
            ..:|:|.|||.:|..:|
  Rat   805 VTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKYPEPLRFFPRKGPSLSHVDSEAHSLVAARD 869

  Fly   157 ---------YEWI--------TSGD-----------VDLSGLNYAVFGLGNKTYEHYNKVAIYVD 193
                     :..:        :|||           ..|:.:.::|||||::.|.|:......||
  Rat   870 SQHRSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVD 934

  Fly   194 KRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLI------------ 246
            ..|||||..|:.::..||:....|:.|.||..:.:.|.||.|.:   |::|.|
  Rat   935 TLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCV---GDDVNIEKANNSLISNDR 996

  Fly   247 ----RQYRL---LEQPD-------VQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELH 297
                .::||   .|.||       |...|:   ..|||.|.||.:.|..:::....      .||
  Rat   997 SWKRNKFRLTYVAEAPDLTQGLSNVHKKRV---SAARLLSRQNLQSPKSSRSTIFV------RLH 1052

  Fly   298 KGGGRSCMHIELSIEGSKMRYDAGDHVAMFPVNDK----SLVEKLGQLCNA----------DLDT 348
            ..|.:            :::|..|||:.:||.|.:    :|:|:|.....|          :.:|
  Rat  1053 TNGNQ------------ELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNT 1105

  Fly   349 VFSLINTDTDSSKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASIS 413
            ...:|:...|.|:   .| |.|...|..:||:||..|....|::.|...|:||||:.|..::
  Rat  1106 ALGVISNWKDESR---LP-PCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLS--- 1163

  Fly   414 PEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAV 478
             :|.::|:.|.......:|.:||:..|.:.|...:...|..|||||||||||..::|.:||:|..
  Rat  1164 -KGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVA 1227

  Fly   479 LVEYKTPTGR--INKGVATTYLKNKQPQGSEEVKVPVFIRKS-QFRLPTKPETPIIMVGPGTGLA 540
            :|.|.|..|.  ::.||.:::|...|   :::| ||.|:|.: .|.||..|:.|.|:||||||:|
  Rat  1228 IVSYHTRDGEGPVHHGVCSSWLNRIQ---ADDV-VPCFVRGAPSFHLPRNPQVPCILVGPGTGIA 1288

  Fly   541 PFRGFIQERQF-LRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGK- 602
            |||.|.|:||| ::.:|......:|.||||:...|:||..|..:...||.. .|..|:||:..:
  Rat  1289 PFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRP 1353

  Fly   603 KVYVQHLL-EQDADLIWNVIGENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKK 666
            |.|||.:| ||.|:.::..:.|..||.|:|||. .||.||...:.:|::.:|.:||.||..:|.:
  Rat  1354 KKYVQDVLQEQLAESVYRALKEQGGHIYVCGDV-TMAADVLKAIQRIMTQQGKLSEEDAGVFISR 1417

  Fly   667 MEAQKRYSADVW 678
            :....||..|::
  Rat  1418 LRDDNRYHEDIF 1429

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	202/720 (28%)
		Flavodoxin_1	86..223	CDD:278677	41/212 (19%)
		CYPOR	281..678	CDD:99801	138/417 (33%)
Nos1	XP_038944987.1	PDZ_signaling	15..98	CDD:238492
		NOS_oxygenase_euk	300..711	CDD:238410
		Flavodoxin_1	757..964	CDD:395199	41/212 (19%)
		Nitric_oxide_synthase	1030..1433	CDD:99799	144/431 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910