DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cpr and Nos2

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	NP_035057.1	Gene:	Nos2 / 18126	MGIID:	97361	Length:	1144	Species:	Mus musculus

Alignment Length:	641	Identity:	205/641 - (31%)
Similarity:	328/641 - (51%)	Gaps:	77/641 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 IKKLKASGRSLVVFYGSQTGTGEEFAGRLAK-EGIRYRLKGMVADPEECDMEELLQLKDIDNSLA 137
            ::|:.||.....|.:.::||..|..|..||. ....:..|.:..|..:....|       :..|.
Mouse   523 MRKVMASRVRATVLFATETGKSEALARDLATLFSYAFNTKVVCMDQYKASTLE-------EEQLL 580

  Fly   138 VFCLATYGEGDPTDNAMEFYEWITSGDVDLSGLN----YAVFGLGNKTYEHYNKVAIYVDKRLEE 198
            :...:|:|.||...|.....:.:..    |..||    |||||||:..|..:...|..:|::|..
Mouse   581 LVVTSTFGNGDCPSNGQTLKKSLFM----LRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSH 641

  Fly   199 LGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIEGGGEEVLI------------RQYRL 251
            |||:::...|.||:.:..||.|.:|..:.:.|.|:.|.:. ....:.|            :||||
Mouse   642 LGASQLAPTGEGDELSGQEDAFRSWAVQTFRAACETFDVR-SKHHIQIPKRFTSNATWEPQQYRL 705

  Fly   252 LEQPD-VQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKVNRELH-KGGGRSCMHIELSIEGS 314
            ::.|: :..:|    .::.:|          |||.|...:|..:.|. :...|:.:.::|:.|||
Mouse   706 IQSPEPLDLNR----ALSSIH----------AKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGS 756

  Fly   315 K-MRYDAGDHVAMFPVNDKSLVEKLGQL---CNADLDTVFSLINTDTDS----SKKHPFPCPTTY 371
            : ..|..|:|:.:||.|..:||:.:.:.   |.....||...:..::.|    .|:.| ||  :.
Mouse   757 RGPSYLPGEHLGIFPGNQTALVQGILERVVDCPTPHQTVCLEVLDESGSYWVKDKRLP-PC--SL 818

  Fly   372 RTALTHYLEITAIPRTHILKELAEYCTDEKEKELLRSMASISPEGKEKYQSWIQDACRNIVHILE 436
            ..|||::|:||..|....|.:||.:.|||.:::.|.::...|     :|..|........:.:||
Mouse   819 SQALTYFLDITTPPTQLQLHKLARFATDETDRQRLEALCQPS-----EYNDWKFSNNPTFLEVLE 878

  Fly   437 DIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHPTDVHVTAVLVEYKTPTGR--INKGVATTYLK 499
            :..|...|...:...||.|:|||||||||....|::||:|..:|.|:|..|:  ::.||.:|:::
Mouse   879 EFPSLHVPAAFLLSQLPILKPRYYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWIR 943

  Fly   500 NKQPQGSEEVKVPVFIRK-SQFRLPTKPETPIIMVGPGTGLAPFRGFIQERQFLRD---EGKTVG 560
            |.:||.    .||.|:|. |.|:||..|..|.|::|||||:||||.|.|:|  |.|   :|...|
Mouse   944 NLKPQD----PVPCFVRSVSGFQLPEDPSQPCILIGPGTGIAPFRSFWQQR--LHDSQHKGLKGG 1002

  Fly   561 ESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAAFSRDQGK-KVYVQHLLE-QDADLIWNVIG 622
            ...|.||||...||::|:.|::|.|:|..| .:...:||..|| |||||.:|: |.|:.:.:|:.
Mouse  1003 RMSLVFGCRHPEEDHLYQEEMQEMVRKRVLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLH 1067

  Fly   623 ENKGHFYICGDAKNMAVDVRNILVKILSTKGNMSEADAVQYIKKMEAQKRYSADVW 678
            ..:||.|||||.: ||.||...|.|:::||.|:||.....|..::::||||..|::
Mouse  1068 GEQGHLYICGDVR-MARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIF 1122

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	203/633 (32%)
		Flavodoxin_1	86..223	CDD:278677	39/141 (28%)
		CYPOR	281..678	CDD:99801	151/414 (36%)
Nos2	NP_035057.1	DINNN-motif, mediates interaction with SPSB1, SPSB2 and SPSB4. /evidence=ECO:0000269\|PubMed:20603330	23..27
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..59
		NOS_oxygenase_euk	78..490	CDD:238410
		Calmodulin-binding. /evidence=ECO:0000255	503..523		205/641 (32%)
		CysJ	534..1121	CDD:223446	201/627 (32%)
		Flavodoxin_1	535..666	CDD:278677	39/141 (28%)
		FNR_like	730..1126	CDD:297884	147/408 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0369
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810