DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cpr and nos2

DIOPT Version :9

Sequence 1:	NP_001260128.1	Gene:	Cpr / 33883	FlyBaseID:	FBgn0015623	Length:	679	Species:	Drosophila melanogaster
Sequence 2:	XP_002935342.2	Gene:	nos2 / 100494698	XenbaseID:	XB-GENE-485093	Length:	1160	Species:	Xenopus tropicalis

Alignment Length:	673	Identity:	204/673 - (30%)
Similarity:	333/673 - (49%)	Gaps:	87/673 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RSRKKEEEPTRSYSIQPTTVCTTSASDNSFIKKLKASGRSLVVFYGSQTGTGEEFAGRLAKEGIR 108
            |..||:|   ..:|:...:|...|    |.:||..|:...:.:.|.::||..|.||.:| :....
Frog   503 RKPKKKE---FKFSVVAKSVLFAS----SLLKKTVAARTKVTILYATETGKSETFAKKL-QALFS 559

  Fly   109 YRLKGMVADPEECDMEELLQLKDIDNSLAVFCLATYGEGDPTDNAMEFYEWITSGDVDLSGLNYA 173
            |.....|...::.::..|     .|.||.:...:|:|.||...|..:|.:.:.|.....:.|.||
Frog   560 YAFNAKVLCMDDYNIRNL-----EDESLLLVVTSTFGNGDCPGNGEKFKKAMFSCKYLKNKLRYA 619

  Fly   174 VFGLGNKTYEHYNKVAIYVDKRLEELGANRVFELGLGDDDANIEDDFITWKDRFWPAVCDHFGIE 238
            |||||:..|..:...|..||:||.:|||.::...|.||:.:..|:.|:.|..:.:.|.|:.|.|.
Frog   620 VFGLGSSMYPQFCAFAHTVDQRLAQLGAAQISLTGEGDELSGQEESFLNWAVQTFKAACELFKIR 684

  Fly   239 G-----------GGEEVLIRQYRLLEQPDVQPDRIYTGEIARLHSIQNQRPPFDAKNPFLAPIKV 292
            .           ..|......|||:.. :.|.|.|..  :.::||..            :.|:|:
Frog   685 DRRNIHLPKCYTSTESWSAENYRLVND-NQQYDHIKA--LCKMHSRS------------IVPMKL 734

  Fly   293 ----NRELHKGGGRSCMHIELSIEGS-KMRYDAGDHVAMFPVNDKSLVE------KLGQLCN--A 344
                |.:..| ..|:.:.::||.|.| ::|:..|:|..:|..|...||.      |....||  .
Frog   735 KFRKNLQSPK-SSRTTLLVKLSYENSQEVRFMPGEHAGLFAGNQPELVASVISHLKDAPPCNQHV 798

  Fly   345 DLDTVFSLINTDTDS----SKKHPFPCPTTYRTALTHYLEITAIPRTHILKELAEYCTDEKEKEL 405
            .|:|     ..:.:|    |:|.| ||..|  .|||::|:||..|...:||:|:...|...:|..
Frog   799 RLET-----RNEQESFWTISEKIP-PCSLT--QALTYFLDITTPPTQLLLKKLSLLATKVTDKSR 855

  Fly   406 LRSMASISPEGKEKYQSWIQDACRNIVHILEDIKSCRPPIDHVCELLPRLQPRYYSISSSAKLHP 470
            |..::    :..::|:.|......|.:.:||:..|.:.|...|...||.|:|||||||||..:.|
Frog   856 LEELS----KDADEYKQWKNHNFPNFLEVLEEFPSLQVPTTFVLTQLPPLKPRYYSISSSRDMVP 916

  Fly   471 TDVHVTAVLVEYKTPTGR--INKGVATTYLKNKQPQGSEEVKVPVFIRKSQ-FRLPTKPETPIIM 532
            .::|:|..:|.|.|..|:  ::.||.:|:|.:.....:    ||.|||.:. |.||..|..|.::
Frog   917 GEIHLTVAVVNYTTRGGQGPLHHGVCSTWLNDLDINET----VPCFIRSTNTFHLPENPSVPCVL 977

  Fly   533 VGPGTGLAPFRGFIQERQF-LRDEGKTVGESILYFGCRKRSEDYIYESELEEWVKKGTL-NLKAA 595
            :|||||::|||||.|:|.: |..:|...|..||.|||::...|.||..|.:....||.| ::..|
Frog   978 IGPGTGISPFRGFWQQRLYDLEKKGIKAGSMILLFGCQQSGMDEIYADETQYMKSKGVLKDVYTA 1042

  Fly   596 FSRDQGK-KVYVQHLLEQDADL-IWNVIGENKGHFYICGD---AKNMAVDVRNILVKILSTKGNM 655
            :||..|: |||||.:|.::.:. :..::.|.:||.|:||:   |||:|..:::::.|.|    .:
Frog  1043 YSRQPGQAKVYVQDILIKNLESEVCRILLEEEGHLYVCGNFEMAKNVAQTLKSMIAKRL----KL 1103

  Fly   656 SEADAVQYIKKMEAQKRYSADVW 678
            :|.:|..|..:::.:.||..|::
Frog  1104 NEEEAENYFSELKNKLRYHEDIF 1126

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cpr	NP_001260128.1	CysJ	80..678	CDD:223446	193/635 (30%)
		Flavodoxin_1	86..223	CDD:278677	42/136 (31%)
		CYPOR	281..678	CDD:99801	137/423 (32%)
nos2	XP_002935342.2	NOS_oxygenase_euk	81..493	CDD:238410
		Flavodoxin_1	538..669	CDD:365983	42/136 (31%)
		FNR_like	733..1127	CDD:384719	136/415 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000