Protein Alignment Pez and FRMD1

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: XP_011534439.1
• Gene: FRMD1 / 79981
• HGNCID: 21240
• Length: 614
• Species: Homo sapiens
• Alignment Length: 614
• Identity: 122/614 - (19%)
• Similarity: 198/614 - (32%)
• Gaps: 195/614 - (31%)

  Fly     9 CRQYNVTSKSLFVISVHH----LLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYLV 69
            |.|...|.....:.|.|.    ||.:...:...:..::.|:|....||....|:..:||||..:
Human    79 CSQQEPTLGMDAMASEHRDVLVLLPSREQLRLAVGVKATGRELFQQVCNVASIRDAQFFGLCVV- 142

  Fly    70 KGKDKEDEFKWIDLERSLSRQL------------EKYAAGPKIYLRVRHYVTTGVRHLSDEATRF 122
                :.:|:.::|||:.||:..            ||..|....:|||:|||..| |.:||...|.
Human   143 ----RNNEYIFMDLEQKLSKYFSKDWKKERNEGNEKPRAPFVAFLRVQHYVENG-RVISDHRARH 202

  Fly   123 YYFLQLKSDIYEGRIACDIRTAILLALYCRQAEYDSYQGD-------------------KQSKDY 168
            .|:..||..:...:.|.......|||....||:...::..                   |:..||
Human   203 LYYCHLKERVLRSQCAHREEAYFLLAACALQADLGEHRESAHAGRYFEPHSYFPQWIITKRGIDY 267

  Fly   169 LKKSL-VLPRNMQGLANDDSMLEGLIVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERFAA 232
            :.:.: .|.|..|||:..::||                        .:||...:||......|..
Human   268 ILRHMPTLHRERQGLSPKEAML------------------------CFIQEACRLEDVPVHFFRL 308

  Fly   233 -KDTLGN--DLLLGLAINGMVV--NADNGRQY---FPWKEFHTVTIDKRTIKIEQNKLDGGGSIV 289
             ||....  .::||||:.|:.:  ..|...|.   .||.....:....:.::|:.:.|.....:|
Human   309 HKDKKEGRPTVILGLALRGVHIYQEVDRAPQLLYDLPWPHVGKLAFLGKKLEIQLDGLPAAQKLV 373

  Fly   290 GSFIFSEADTARYFWKLTISQHKFFKRYIDTATPSSLGSGADAESGPLGVDSVGYVDYDYNEAAA 354
              :.......:|:...|..:.|:...|...|
Human   374 --YYTGCTWRSRHLLHLLRASHQLHLRVRPT---------------------------------- 402

  Fly   355 AEQLQQHHQQQQHMQQQQQIQQQQMISSNISLATSANQMLGQSSS------CLDLSNNNLHSSSG 413
               |||..|:::  .:::|..::..||..:.|..::....|...|      ||...:.:.|.||
Human   403 ---LQQLRQREE--AEEKQHYRESYISDELELDLASRSFPGSGVSSQHCPHCLSRHSADSHGSS- 461

  Fly   414 MLHHGGSNNNNNNDERERLKAMLP----------------TYRPAPD---------YETAVQLKY 453
              :..|...|:...|...:...:|                |.|..|.         .|...|::.
Human   462 --YTSGIKANSWLRESREMSVDVPLEVHGLHEKEPSSSPRTSRSHPSTRGDSQATRQEPCTQVRT 524

  Fly   454 RTPSAE-FHNVALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHIN 517
            |..||| .|.:        ....||...:.|:.|:.:..|
Human   525 RGQSAEAVHQI--------QEMTAGVSEEQHSHGLDDMQL------------------------- 556

  Fly   518 LYQAQHQPQSHPQPMSPAQAYLELSQRMH 546
                 ||...||.|.|       ||...|
Human   557 -----HQLALHPAPTS-------LSHTFH 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619	25/105 (24%)
		FERM_M	112..230	CDD:459788	27/137 (20%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	18/99 (18%)
		PTP_DSP_cys	1036..1246	CDD:475123
FRMD1	XP_011534439.1	FERM_F1_FRMD1	95..192	CDD:340717	27/101 (27%)
		FERM_M	190..306	CDD:459788	28/140 (20%)
		FERM_C_FRMD1_FRMD6	299..407	CDD:270006	24/146 (16%)