Protein Alignment Pez and ptpn21

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: XP_005169845.1
• Gene: ptpn21 / 799627
• ZFINID: ZDB-GENE-080102-4
• Length: 1204
• Species: Danio rerio
• Alignment Length: 1385
• Identity: 386/1385 - (27%)
• Similarity: 602/1385 - (43%)
• Gaps: 314/1385 - (22%)

  Fly     1 MPLKF---LKKCRQYNVTSKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEF 62
            |||.|   ||:.|:|.|:|||..|..:..|  ....|:.|:|.||.|||||:.|.|||.:::..:
Zfish     1 MPLPFGLKLKRTRRYTVSSKSCLVTRIQLL--NGEYVEFTLSVESTGQECLEAVAQRLELREITY 63

  Fly    63 FGLRYLVKGKDKEDEFKWIDLERSLSRQLEKYAAGPKIYLRVRHYVTTGVRHLSDEATRFYYFLQ 127
            |.|.|.    :|:::.:|||||:.|.:||:||...|.:|..|..||.| |..|..|.||:.|:||
Zfish    64 FSLWYY----NKQNQQRWIDLEKPLKKQLDKYGLEPTVYFGVVFYVCT-VTQLQQEITRYQYYLQ 123

  Fly   128 LKSDIYEGRIACDIRTAILLALYCRQA---EYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSML 189
            ||.|:.||:|.|.|..||.||....||   :::.|    .|:::|:|.::.|   .....|:.::
Zfish   124 LKKDVLEGKIPCSIEQAIHLASLAVQADLGDFNRY----DSQEFLQKIVLFP---MPWIQDERVV 181

  Fly   190 EGLIVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNAD 254
            |....:|.........||..:||.:|:|..:::||||||...|||:...|:::|..::|:.|...
Zfish   182 EEATQKVTMLYQNYRGLSAPEAELLYMQEVEKIEGYGEESIQAKDSQATDVIIGSCLDGIFVKHK 246

  Fly   255 NGRQ--YFPWKEFHTVTIDKRTIKIE-QNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKR 316
            ||:.  .|.|.:.:.:|.:|....:| .||.|     ...|...:.:|::|..::.:::|||:|
Zfish   247 NGKAPLIFRWNDINNMTHNKSFFALELANKED-----TIQFQTEDMETSKYVCRMWLARHKFYK- 305

  Fly   317 YIDTATPSSLGSGADAES-GP-LGVDSVGY------------VDYDYNEAAAAEQLQQHHQQQQH 367
                ...|||....|..| || ..:.|:.:            .|....:.|....:::....:..
Zfish   306 ----INNSSLEPSCDPNSEGPQRSILSLSFPRFPALSRLSVPADKGQTQPAPVNPVRRRSSTRMS 366

  Fly   368 MQQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNN-------------LHSSSGMLHHGG 419
            :.:    .|..|:...:......|:....|...|.::|.|             .|..:|.:.:|.
Zfish   367 LPK----PQPYMMPPQMHFNGHYNEPYTSSQDNLYINNQNGFYYHSQTSLDRSPHEYNGRIRNGS 427

  Fly   420 -----SNNNNNNDER--------------------------ERLKAML-PTYRPAPDYETAVQLK 452
                 |.::.||.:.                          .|..|:: |:||..|||||.::.|
Zfish   428 VYSAQSTSSLNNPQHYLQPSPMSSNPSITGSDLMRPDYVPSHRHSALIPPSYRATPDYETVMRQK 492

  Fly   453 YRTPSAEFHNVALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHIN 517
            ...|:||..:.::.....||: ||.|:||   |.::::..:..| .|.:||          .|:|
Zfish   493 NMIPAAERQSHSMRNLNIGNS-YAYSRPD---PLVYSQPEIREH-GAGQYP----------FHLN 542

  Fly   518 LYQAQHQPQSHPQPMS----------PAQAYLELSQRM-----HMMRHKA----PP-PYVNRLSS 562
              .:.|.|..:|.|..          |....::|.|..     :::|::.    || ||.:...:
Zfish   543 --YSFHSPSPYPYPTERRPVVGAVSVPELTNVQLQQAQEYPPPNIIRNQVYWPPPPYPYPHPRPA 605

  Fly   563 SSTPDLAVATPRPLQGFRNYVSGSSPDLVSNRTLFNGGQYVALPAGGHAGNIPTSSGATMLHQYQ 627
            :|||||:    |.|     |||.|:|||::.|
Zfish   606 NSTPDLS----RHL-----YVSSSNPDLITRR--------------------------------- 628

  Fly   628 YVSHMGHSQPYLPPHGTFENLNMIEEQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRS 692
             |.|                                            ||.|....:||.:....
Zfish   629 -VHH--------------------------------------------SVQTFQEDSLPVAHSLQ 648

  Fly   693 SVPPPASSPLPPPVVASSHKSATPAPLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQR 757
            .|..|..:...|.:    ||       :.|:....:....||:.|.:|..  |:.||:|
Zfish   649 EVSEPLVTARRPHM----HK-------RNSIEIAGLAYGLENMRLKERKV--SASAADT------ 694

  Fly   758 ASSIQSAPGVVPVPAARNASSNNVVTVTVNSPPDDGNIKK---YGADRAASTELLFL-----EPQ 814
                 ..|....||.|.:.|..|||...  |.|:|..||:   ||..::.|...:.:     |.:
Zfish   695 -----PPPVAAAVPHAASGSDINVVLEV--SKPEDVGIKEDVFYGHKKSLSDATMLVHSSGEEEE 752

  Fly   815 APKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFS-AMN--LSANTSAS 876
            ....:.|....:.|..:.|   :|..| ||.:|        .||.....|| :|.  |::..:..
Zfish   753 FEDDSGRHTPQSQDAVSGP---EHPMT-SLGRS--------LGDPPAYPFSHSMETVLTSPPAYQ 805

  Fly   877 TSSMFNSTLDT-----------TSSSAASKDLKRKKRWNFLSRSKTP-----------DKQKSAT 919
            ..|:.....|.           ...|.:..||..:.|.| ...||.|           |....|.
Zfish   806 AHSIMQKAEDVGPLPPLREPGLMMPSVSEGDLSGRLRKN-RDISKRPVSDVPPGRRNIDGLPPAG 869

  Fly   920 L--GREKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQKLSDSQ 982
            :  ||.:....|. .||||...|....:.||:.     .|..|.|.  |.|:.|:.|:|:|....
Zfish   870 MKKGRSEVKKVGP-LKLAALNGLTLSRIPLPDD-----GKDDPESA--SNDERCKFLEQRLDQGM 926

  Fly   983 LFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATVG 1047
            :|.|:|::||:|.::.|..|.:.||..:|...:.|||||.||.|.|.::|..||:|||.|..||.
Zfish   927 VFTEYEQVPKKRPNSEYSIAQMPENNDRNRFQDVLPYDDTRVELVPTKENNTGYINASHIRVTVR 991

  Fly  1048 TKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLT--------EDMSYIPR--NSHQRLEFGQ 1102
            .|:..||.:|.|... |.:.|||.|||..|.::..:|        :...|.||  :.|..:.:|:
Zfish   992 GKEWSYIASQGPLSS-TCQDFWQMVWEQGVSIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGR 1055

  Fly  1103 FQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLA 1167
            |::...|...:....|..|::.|:.:.:.|:||:|||.||.:..||.|...||.:|||:.|||..
Zfish  1056 FKITTRFRTDSGCYATTGLKIKHLLTGQERTVWHLQYTDWPDHGCPEDFKGFLSYLEEIQSVRRH 1120

  Fly  1168 STQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSL 1232
            :.....| .|||.|||:||..|.||:||.:.:::::..|:|||.||:|.|:..||.||..::.:|
Zfish  1121 TNSSSDP-KNTNLPVLVHCSAGVGRTGVVILSEIMIACLEHNEMLDVPTVLNLLRQQRMMMVQTL 1184

  Fly  1233 AQYKFIYNLLITYLKRTRLI 1252
            :||.|||.:||.:||.:|||
Zfish  1185 SQYTFIYKVLIQFLKNSRLI 1204

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619	35/89 (39%)
		FERM_M	112..230	CDD:459788	42/120 (35%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	28/94 (30%)
		PTP_DSP_cys	1036..1246	CDD:475123	84/219 (38%)
ptpn21	XP_005169845.1	Ubl1_cv_Nsp3_N-like	20..105	CDD:475130	35/90 (39%)
		B41	26..220	CDD:214604	75/207 (36%)
		FERM_C_PTPN14_PTPN21	217..307	CDD:270009	28/99 (28%)
		PTP_DSP_cys	914..1199	CDD:475123	110/286 (38%)