Protein Alignment Pez and PTPN14

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_005392.2
• Gene: PTPN14 / 5784
• HGNCID: 9647
• Length: 1187
• Species: Homo sapiens
• Alignment Length: 1391
• Identity: 369/1391 - (26%)
• Similarity: 595/1391 - (42%)
• Gaps: 343/1391 - (24%)

  Fly     1 MP--LKFLKKCRQYNVTSKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFF 63
            ||  || |::.|:|||.||:.||..: .||| |:.::||:|.||.|||||:.|.|||.:::..:|
Human     1 MPFGLK-LRRTRRYNVLSKNCFVTRI-RLLD-SNVIECTLSVESTGQECLEAVAQRLELRETHYF 62

  Fly    64 GLRYLVKGKDKEDEFKWIDLERSLSRQLEKYAAGPKIYLRVRHYVTTGVRHLSDEATRFYYFLQL 128
            ||.:|    .|..:.:|::||:.|.:.|:|:|..|.::..|..|| ..|..|..||||:.|:||:
Human    63 GLWFL----SKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYV-PNVSWLQQEATRYQYYLQV 122

  Fly   129 KSDIYEGRIACDIRTAILLALYCRQAEYDSY-QGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGL 192
            |.|:.|||:.|.:...|.||....||::..| |.|  |:|:|::.::.|.:   ||.::::||.|
Human   123 KKDVLEGRLRCTLDQVIRLAGLAVQADFGDYNQFD--SQDFLREYVLFPMD---LALEEAVLEEL 182

  Fly   193 IVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNADNGR 257
            ..:|.|:....:.:..::||.|||...::|:|:|:|.|..||..||.:.||:...|:.|....||
Human   183 TQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGR 247

  Fly   258 Q--YFPWKEFHTVTIDKRTIKIEQ-NKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFK---- 315
            |  .:.|.:...:|.:|.||.:|. ||.:     ...|...:.:.|:|..:|..::|||:|
Human   248 QAVIYRWNDMGNITHNKSTILVELINKEE-----TALFHTDDIENAKYISRLFATRHKFYKQNKI 307

  Fly   316 -----------RYIDTATPSSLGSGADAESGPLGVDSVGYVDYDYNEAAAAEQLQQHHQQQQHMQ 369
                       |...|.:.|||.........|:.|                 |..:|:.:....|
Human   308 CTEQSNSPPPIRRQPTWSRSSLPRQQPYILPPVHV-----------------QCGEHYSETHTSQ 355

  Fly   370 QQQQIQQQQMISSNISLATSANQMLG---QSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDERER 431
            .......::.:..|...:...|.:.|   ..|.|...|.|:|:.|...:.....::|.:....:.
Human   356 DSIFHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNSLNCSQSFIQASPVSSNLSIPGSDI 420

  Fly   432 LKA-----------MLPTYRPAPDYETAVQLKYR------TPSAEFHNVAL----AMAAPGNAYY 475
            ::|           ::|:|||.|||||.::...|      :.|....|:.:    |...|.:..|
Human   421 MRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDSQSQSLRNLNIINTHAYNQPEDLVY 485

  Fly   476 AGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQSHPQPMSPAQAYL- 539
              |||::..  .|...:.||            |.....:.:.....|..|:::..|..|..:.:
Human   486 --SQPEMRE--RHPYTVPYG------------PQGVYSNKLVSPSDQRNPKNNVVPSKPGASAIS 534

  Fly   540 ------ELSQRM----------HMMRH---KAPPPYVNRLSSSSTPDLAVATPRPLQGFRNYVSG 585
                  ||:...          ||:::   :.||||.....::||||||       .....||||
Human   535 HTVSTPELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLA-------SHRHKYVSG 592

  Fly   586 SSPDLV--------------SNRTLFNGGQYVALP--AGGHAG---------------------- 612
            ||||||              |:..:....|.|:.|  |..|.|
Human   593 SSPDLVTRKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGTVNKRHSLEVMNSMVRGMEAMT 657

  Fly   613 ----NIPTSSGATMLHQYQYVSHMG-HSQPYLPPH---GTFENLNMI---------EEQ------ 654
                ::|.:...|:..|.......| |..|.||.:   .||.:..|:         ||:
Human   658 LKSLHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLIHSSESEEEEEEAPESVP 722

  Fly   655 --PSIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSHKSATPA 717
              |.:..::..||..|||.|..        |..||..|                         |.
Human   723 QIPMLREKMEYSAQLQAALARI--------PNKPPPEY-------------------------PG 754

  Fly   718 PLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVVPVPAARNASSNNVV 782
            | ::|:.||                          |:||..:|:       |...||
Human   755 P-RKSVSNG--------------------------ALRQDQASL-------PPAMAR-------- 777

  Fly   783 TVTVNSPPDDGNIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKS 847
                      ..:.::|..:|.|                       |..|.||..  :.|||..|
Human   778 ----------ARVLRHGPAKAIS-----------------------MSRTDPPAV--NGASLGPS 807

  Fly   848 STVDMITPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTP 912
            .:...:|...:.::::       .......|.||:............::|:::|... |...|.|
Human   808 ISEPDLTSVKERVKKE-------PVKERPVSEMFSLEDSIIEREMMIRNLEKQKMAG-LEAQKRP 864

  Fly   913 DKQKSATLGREKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQK 977
             ...:|..|...|..:|:........::..|:     |:.|                    |.:|
Human   865 -LMLAALNGLSVARVSGREENRVDATRVPMDE-----RFRT--------------------LKKK 903

  Fly   978 LSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSI 1042
            |.:..:|.|:|:|||::.:.::..|.|.||..::.....:||::|||.|.|.::|..||:|||.|
Human   904 LEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVVPYEENRVELIPTKENNTGYINASHI 968

  Fly  1043 SATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPR--NSHQR 1097
            ...||..:..||..|.|. |.|...|||.|||..|.::..:|.:..        |.|:  :.|..
Human   969 KVVVGGAEWHYIATQGPL-PHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSS 1032

  Fly  1098 LEFGQFQVYQEFSQTTDRC-TTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL 1161
            ..:|:|:|..:| :|...| .|..|::.|:.|.:.|:||:|||.||.:..||.||..||.:|||:
Human  1033 ATYGKFKVTTKF-RTDSVCYATTGLKVKHLLSGQERTVWHLQYTDWPDHGCPEDVQGFLSYLEEI 1096

  Fly  1162 NSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRD 1226
            .|||..:...:....|.:||:::||..|.||:||.:.::|::|.|:|||.:::|.::..||.||.
Human  1097 QSVRRHTNSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPMMLRLLREQRM 1161

  Fly  1227 SIIPSLAQYKFIYNLLITYLKRTRLI 1252
            .:|.::|||||:|.:||.:|:.:|||
Human  1162 FMIQTIAQYKFVYQVLIQFLQNSRLI 1187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619	35/89 (39%)
		FERM_M	112..230	CDD:459788	43/118 (36%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	30/109 (28%)
		PTP_DSP_cys	1036..1246	CDD:475123	84/220 (38%)
PTPN14	NP_005392.2	B41	24..220	CDD:214604	77/207 (37%)
		FERM_C_PTPN14_PTPN21	215..305	CDD:270009	30/94 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..531		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	671..690		4/18 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..824		11/68 (16%)
		PTPc-N14	896..1182	CDD:350447	108/307 (35%)