DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pez and PTPN13

DIOPT Version :9

Sequence 1:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	XP_011530467.1	Gene:	PTPN13 / 5783	HGNCID:	9646	Length:	2507	Species:	Homo sapiens

Alignment Length:	1972	Identity:	347/1972 - (17%)
Similarity:	603/1972 - (30%)	Gaps:	800/1972 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 VHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYLVKGKDKEDEFKWIDLERSLS 88
            |:.:|.....::.|..:::..::..|.|...:.:.:...|.|..|     |::|:.::|.:..|:
Human   574 VNIMLLNGQRLELTCDTKTICKDVFDMVVAHIGLVEHHLFALATL-----KDNEYFFVDPDLKLT 633

  Fly    89 RQL-EKYAAGPK----------IYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDIYEGRIACDIR 142
            :.. |.:...||          ::.|::.:: ..|..:....|...|:|||:.||.|.|:.||..
Human   634 KVAPEGWKEEPKKKTKATVNFTLFFRIKFFM-DDVSLIQHTLTCHQYYLQLRKDILEERMHCDDE 697

  Fly   143 TAILLALYCRQAEYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAH-- 205
            |::|||....||||..||.:.....|.:....||..         ::|.|.:..::::....|
Human   698 TSLLLASLALQAEYGDYQPEVHGVSYFRMEHYLPAR---------VMEKLDLSYIKEELPKLHNT 753

  Fly   206 ---LSQSQAEEMYIQCCQQLEGYGE--ERFAAKDTLGNDLLLGLAINGMVV-NADNGRQ----YF 260
               .|:.:.|..:::.||:|..||.  .|...:......:|||:...|::| ...||.:    .|
Human   754 YVGASEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRTLVLRF 818

  Fly   261 PWKEFHTVTIDKRTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRY-------- 317
            ||:|...::..|:.|.: ||..||   |...|....:...:|...|...||||..:.
Human   819 PWRETKKISFSKKKITL-QNTSDG---IKHGFQTDNSKICQYLLHLCSYQHKFQLQMRARQSNQD 879

  Fly   318 ---IDTATPSSLGSGADAESG-----------------------PLGVDS--------------- 341
               |:.|:..||...|::..|                       ||.|.:
Human   880 AQDIERASFRSLNLQAESVRGFNMGRAISTGSLASSTLNKLAVRPLSVQAEILKRLSCSELSLYQ 944

  Fly   342 -VGYVDYDYNEAAAAEQLQQHHQQQQH-MQQQQQIQQQQMISSNIS---------LATSANQM-- 393
             :.....:.|:.|:.|:..:...:..| :.|......::.:..|:.         :...::||
Human   945 PLQNSSKEKNDKASWEEKPREMSKSYHDLSQASLYPHRKNVIVNMEPPPQTVAELVGKPSHQMSR 1009

  Fly   394 -----------LGQSSSCLDLSNN---NLHSSS-------------GMLHHGGSNNNN-----NN 426
                       |..|.|...|:.:   ..|.|.             ||..|...|:::     .|
Human  1010 SDAESLAGVTKLNNSKSVASLNRSPERRKHESDSSSIEDPGQAYVLGMTMHSSGNSSSQVPLKEN 1074

  Fly   427 D------------ERE-------------------------RLKAMLPTYRPAP----DYETAVQ 450
            |            |||                         ||...:.....||    |.:..::
Human  1075 DVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLK 1139

  Fly   451 -----LKYRTPSAE--FHNVALAMA--APGNAYYAGSQP-----DVHNPGMHNENLLYGHMTAHR 501
                 :...:.|.|  .|:.|:.:.  ||.:.....|||     .|.:..:|..|.:..:|....
Human  1140 PGDRLISVNSVSLEGVSHHAAIEILQNAPEDVTLVISQPKEKISKVPSTPVHLTNEMKNYMKKSS 1204

  Fly   502 Y-PDVAQPAAALHHH-----------------------------------------INLYQAQH- 523
            | .|.|..:::..||                                         :|.:.|.|
Human  1205 YMQDSAIDSSSKDHHWSRGTLRHISENSFGPSGGLREGSLSSQDSRTESASLSQSQVNGFFASHL 1269

  Fly   524 -----QPQSHPQPMSPA--------QAYLELSQ------------------------------RM 545
                 |...|..| ||:        :.:.:.:|                              :.
Human  1270 GDQTWQESQHGSP-SPSVISKATEKETFTDSNQSKTKKPGISDVTDYSDRGDSDMDEATYSSSQD 1333

  Fly   546 HMMRHKAPPPYVNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDL-VSNRTLF----------NG 599
            |....:.....||..:..:....:.:.|:|...|...::.:...| :|...||          :|
Human  1334 HQTPKQESSSSVNTSNKMNFKTFSSSPPKPGDIFEVELAKNDNSLGISVTVLFDKGGVNTSVRHG 1398

  Fly   600 GQYV--ALPAGG-------HAG------NIPTSSGATMLHQYQYVSHMGH-------------SQ 636
            |.||  .:|.|.       |.|      |..:..|||.....:.:.:.|.             |:
Human  1399 GIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQSPTSK 1463

  Fly   637 PYLP---------------------------------PHGTFE----------------NLNMIE 652
            .::|                                 ...|||                ..|:|.
Human  1464 EHVPVTPQCTLSDQNAQGQGPEKVKKTTQVKDYSFVTEENTFEVKLFKNSSGLGFSFSREDNLIP 1528

  Fly   653 EQ--PSIMSQLRQSAMSQAAAAA----AGSVVTQ--------------------SSPTL------ 685
            ||  .||: ::::....|.||.:    .|.|:.:                    ::|.:
Human  1529 EQINASIV-RVKKLFPGQPAAESGKIDVGDVILKVNGASLKGLSQQEVISALRGTAPEVFLLLCR 1592

  Fly   686 PPSGYRSSVPPPASSPLPPPVVA---SSHKSATPAPLQRSL------------------------ 723
            ||.|....:.....:||..|...   ||..|:.|:.:::|.
Human  1593 PPPGVLPEIDTALLTPLQSPAQVLPNSSKDSSQPSCVEQSTSSDENEMSDKSKKQCKSPSRRDSY 1657

  Fly   724 --VNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQS----------------------- 763
              .:||.|.  :.|..|...|..:..:|..:.:....|..||
Human  1658 SDSSGSGED--DLVTAPANISNSTWSSALHQTLSNMVSQAQSHHEAPKSQEDTICTMFYYPQKIP 1720

  Fly   764 -----------------APGVVPVPAARNASSNNV----------VTVTVNSPPDDGNIKKYGAD 801
                             |||....|.:.:|||:::          .|...|..|...:::.:..|
Human  1721 NKPEFEDSNPSPLPPDMAPGQSYQPQSESASSSSMDKYHIHHISEPTRQENWTPLKNDLENHLED 1785

  Fly   802 RAASTELL------------FLEPQAPKR---------------------------------TN- 820
            .....|||            |...:..:|                                 ||
Human  1786 FELEVELLITLIKSEKGSLGFTVTKGNQRIGCYVHDVIQDPAKSDGRLKPGDRLIKVNDTDVTNM 1850

  Fly   821 ---------RAASAA---------------------PDMGATPPPRQ--------H--------- 838
                     ||||..                     ||:..|....:        |
Human  1851 THTDAVNLLRAASKTVRLVIGRVLELPRIPMLPHLLPDITLTCNKEELGFSLCGGHDSLYQVVYI 1915

  Fly   839 -----RSTAS-------LNKSSTVDMITPAGDTLQQQFSAMNLSANT---SASTSSMFNSTLDTT 888
                 ||.|:       |:....|:.::..|.||::...|:::|..:   .|:.:.:........
Human  1916 SDINPRSVAAIEGNLQLLDVIHYVNGVSTQGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKR 1980

  Fly   889 SSSAASKDLKRKKRWNFLSRSK---TPDKQKSATLGRE---------KATT-------------- 927
            |:.:|.|..|....::..|.|:   ||:...|...|.|         |.:|
Human  1981 SAVSAPKSTKGNGSYSVGSCSQPALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPNLTLPKG 2045

  Fly   928 -----AGQHSKLA--AKLKLAQDDL----------------------NLPNR-----WSTG---- 954
                 :..:||..  ::..:.:||:                      ||.|.     :|.|
Human  2046 SFPNQSSNYSKCPNNSESYIQEDDIYDDSQEAEVIQSLLDVVDEEAQNLLNENNAAGYSCGPGTL 2110

  Fly   955 -----------------------------------------------VNKPQ------------- 959
                                                           :.|||
Human  2111 KMNGKLSEERTEDTDCDGSPLPEYFTEATKMNGCEEYCEEKVKSESLIQKPQEKKTDDDEITWGN 2175

  Fly   960 ---PI------------------------------SGRYSKDKLCQI-------LDQKLSDSQLF 984
               ||                              ||:|:...|..:       |||.:...:|
Human  2176 DELPIERTNHEDSDKDHSFLTNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKEL- 2239

  Fly   985 MEFERIPKRREHALYECAL--LEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATVG 1047
               |.:.:.:  .|.:|.:  .:||..||...|.||||..||.|    .:..||:|||.|...||
Human  2240 ---ENLQELK--PLDQCLIGQTKENRRKNRYKNILPYDATRVPL----GDEGGYINASFIKIPVG 2295

  Fly  1048 TKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPR--------NSHQ 1096
            .::..||..|.|. |.|:..|||.:||....::..:|:::.        |.|.        ::..
Human  2296 KEEFVYIACQGPL-PTTVGDFWQMIWEQKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSNRL 2359

  Fly  1097 RLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL 1161
            ||...:.|..:.|   ..|..|::    .:.:|..|.:.:|.:..|.:.:.|...:..|.|:..:
Human  2360 RLALVRMQQLKGF---VVRAMTLE----DIQTREVRHISHLNFTAWPDHDTPSQPDDLLTFISYM 2417

  Fly  1162 NSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRD 1226
            ..:           |.:. |::.||..|.||||..:..|::|..:..:.|.||..::..:|.||.
Human  2418 RHI-----------HRSG-PIITHCSAGIGRSGTLICIDVVLGLISQDLDFDISDLVRCMRLQRH 2470

  Fly  1227 SIIPSLAQYKFIYNLLITYLKR 1248
            .::.:..||.|.|.:::..|.|
Human  2471 GMVQTEDQYIFCYQVILYVLTR 2492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_001260127.1	B41	26..230	CDD:214604	50/221 (23%)
		FERM_N	26..93	CDD:286467	11/67 (16%)
		FERM_M	114..230	CDD:278785	34/122 (28%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	28/98 (29%)
		Y_phosphatase	1007..1243	CDD:278528	67/251 (27%)
		PTPc	1009..1243	CDD:238006	66/249 (27%)
PTPN13	XP_011530467.1	KIND	3..190	CDD:214801
		B41	573..781	CDD:214604	51/221 (23%)
		FERM_N	576..638	CDD:286467	11/66 (17%)
		FERM_M	668..781	CDD:278785	34/121 (28%)
		PH-like	777..877	CDD:302622	27/103 (26%)
		PDZ_signaling	1091..1175	CDD:238492	11/83 (13%)
		PTN13_u3	1177..1367	CDD:293207	25/190 (13%)
		PDZ_signaling	1366..1455	CDD:238492	18/88 (20%)
		PDZ	1503..1594	CDD:214570	15/91 (16%)
		PDZ_signaling	1791..1870	CDD:238492	11/78 (14%)
		PDZ_signaling	1888..1966	CDD:238492	13/77 (17%)
		PTPc	2236..2488	CDD:214550	72/281 (26%)
		PTPc	2262..2488	CDD:238006	66/249 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810