Protein Alignment Pez and PTPN12

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: XP_047276629.1
• Gene: PTPN12 / 5782
• HGNCID: 9645
• Length: 807
• Species: Homo sapiens
• Alignment Length: 268
• Identity: 69/268 - (25%)
• Similarity: 116/268 - (43%)
• Gaps: 35/268 - (13%)

  Fly   992 KRREHALYECAL--LEENEPKNHDPNFLPYDDNRVRL---TPCRDNRHGYVNASSISATVGTKQR 1051
            |.|...:|..|.  .|||..||...:.||:|.:||:|   ||.:|:  .|:||:.|....|.|.
Human    68 KYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDS--DYINANFIKGVYGPKA- 129

  Fly  1052 FYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPRNSHQRLEFGQFQVYQE 1108
             |:..|.|... |:..||:.:||.:|.::|....:..        |.|......:.|..|::..|
Human   130 -YVATQGPLAN-TVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCE 192

  Fly  1109 FSQT-TDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEV 1172
            ..|. ||......|..:...|||   ::...|.:|.:.:.|...:..||.:..:...:
Human   193 DEQARTDYFIRTLLLEFQNESRR---LYQFHYVNWPDHDVPSSFDSILDMISLMRKYQ------- 247

  Fly  1173 PPGHNTNPPVLLHCLEGGGRSGVTLTADL---LLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQ 1234
               .:.:.|:.:||..|.||:|.....|.   ||......|:.::..:|.::|.||.|.:.:..|
Human   248 ---EHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQ 309

  Fly  1235 YKFIYNLL 1242
            |:.::..:
Human   310 YELVHRAI 317

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619
		FERM_M	112..230	CDD:459788
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		PTP_DSP_cys	1036..1246	CDD:475123	51/219 (23%)
PTPN12	XP_047276629.1	PTP_DSP_cys	60..325	CDD:475123	69/268 (26%)