Protein Alignment Pez and PTPN4

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_002821.1
• Gene: PTPN4 / 5775
• HGNCID: 9656
• Length: 926
• Species: Homo sapiens
• Alignment Length: 1272
• Identity: 269/1272 - (21%)
• Similarity: 427/1272 - (33%)
• Gaps: 411/1272 - (32%)

  Fly    10 RQYNVTSKSLFVISVH-----HLLDTSSTVDC-TISSESKGQECLDNVCQRLLIQQPEFFGLRYL 68
            |.|||.:..|.....|     ::|...:||.. .::...:||..||.|.:.|.:.:.::|||:.
Human    11 RTYNVRASELARDRQHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQL- 74

  Fly    69 VKGKDKEDEFKWIDLERSLSRQLEKYAAGP-KIYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDI 132
              ..|..|..:|:|..:.:.:||::  ..| .:..||:.:| :....|.:|.||:.||||:|.||
Human    75 --ADDSTDNPRWLDPNKPIRKQLKR--GSPYSLNFRVKFFV-SDPNKLQEEYTRYQYFLQIKQDI 134

  Fly   133 YEGRIACDIRTAILLALYCRQAEYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVL 197
            ..||:.|...||.|||.:..|:|...|...:....||.....:|...|....:       |.::.
Human   135 LTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDFEKE-------IAKLH 192

  Fly   198 QQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNADNGR-QYFP 261
            ||..|   ||.::||..|:...:.||.||.|...|:|...|::::|:...|:::..:..| ..||
Human   193 QQHIG---LSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVRMNTFP 254

  Fly   262 WKEFHTVTIDKRTIKIEQNK-LDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRYIDTATPS- 324
            |.:...::...:...|:..| |......:..|........:..||..:..|.||:  :|...|.
Human   255 WLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFR--LDRPLPPQ 317

  Fly   325 --------SLGSGADAESGPLGVDSVGYVDYDYNEAAAAEQLQQHHQQQQHMQQQQQIQQQQMIS 381
                    :||| .....|...|.||.|    ..|.|..:::   ..:.......:::...:::|
Human   318 KNFFAHYFTLGS-KFRYCGRTEVQSVQY----GKEKANKDRV---FARSPSKPLARKLMDWEVVS 374

  Fly   382 SNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDERERLKAMLPTYRPAPDYE 446
            .|                  .:|::.|.:.|                       ||:..|
Human   375 RN------------------SISDDRLETQS-----------------------LPSRSP----- 393

  Fly   447 TAVQLKYRTPSAEFHNVALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAA 511
                                                  ||..|          ||.....|....
Human   394 --------------------------------------PGTPN----------HRNSTFTQEGTR 410

  Fly   512 LHHHINLYQAQHQPQSHPQPMSPAQAYLELSQRMHMMRHKAPPP-YVNRLSSSSTPDLAVATPRP 575
            |           :|.|             :...:..|.|.:|.. :||:.|.|||...::
Human   411 L-----------RPSS-------------VGHLVDHMVHTSPSEVFVNQRSPSSTQANSI----- 446

  Fly   576 LQGFRNYVSGSSPDLVSNRTLFNGGQYVALPAGGHAGNIPTSSGATMLHQYQYVSHMGHSQPYLP 640
                   |..|||   |..|. ..|:..|||        |..|.....:|.    |..|||..|.
Human   447 -------VLESSP---SQETP-GDGKPPALP--------PKQSKKNSWNQI----HYSHSQQDLE 488

  Fly   641 PH--GTFENLNMIEEQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLP 703
            .|  .||:                                               :|   |||..
Human   489 SHINETFD-----------------------------------------------IP---SSPEK 503

  Fly   704 PPVVASSHKSATPAPLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVV 768
            |          ||        ||.|.  ::|:
Human   504 P----------TP--------NGGIP--HDNL--------------------------------- 515

  Fly   769 PVPAARNASSNNVVTVTVNSPPDDG-----NIKKYGADRAASTELLFLEPQAPKRTNRAASAAPD 828
                           |.:...||:.     |:|. |.|:           :.|...:|.|...|.
Human   516 ---------------VLIRMKPDENGRFGFNVKG-GYDQ-----------KMPVIVSRVAPGTPA 553

  Fly   829 MGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAA 893
            ....|         .||:...|.:|. ..|..:.....:.|....|....|   ..|.......|
Human   554 DLCVP---------RLNEGDQVVLIN-GRDIAEHTHDQVVLFIKASCERHS---GELMLLVRPNA 605

  Fly   894 SKDLKRKKRWNFLSRSKTPDKQKSATLGREKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKP 958
            ..|:..:|..|      .||.|...    |||.....|          |||.:|
Human   606 VYDVVEEKLEN------EPDFQYIP----EKAPLDSVH----------QDDHSL----------- 639

  Fly   959 QPISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNR 1023
                    ::.:.|:.:..::.:.| .:|:::.:::......||.|.:|..||...:..|||..|
Human   640 --------RESMIQLAEGLITGTVL-TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATR 695

  Fly  1024 VRLTPCRDNRHGYVNASSISATVGTKQ--RFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTED 1086
            |.|....|    |:||:.|:..:.:..  ..||..|.|. |.|...|||..||....:||.||..
Human   696 VILKGNED----YINANYINMEIPSSSIINQYIACQGPL-PHTCTDFWQMTWEQGSSMVVMLTTQ 755

  Fly  1087 MSYIPRNSHQ-------RLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAE 1144
            :.......||       ...:|.:||.....:........|:.|::......|.:..:||..|.:
Human   756 VERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPD 820

  Fly  1145 QNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN 1209
            ...|.|.:.||||:..:.:.| |..:|         ||::||..|.||:||.:|.:..:..::.|
Human   821 HGVPDDSSDFLDFVCHVRNKR-AGKEE---------PVVVHCSAGIGRTGVLITMETAMCLIECN 875

  Fly  1210 E---DLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI 1243
            :   .|||.|.   :|.||..:|.:.:||:|:...::
Human   876 QPVYPLDIVRT---MRDQRAMMIQTPSQYRFVCEAIL 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619	23/96 (24%)
		FERM_M	112..230	CDD:459788	40/117 (34%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	21/93 (23%)
		PTP_DSP_cys	1036..1246	CDD:475123	61/220 (28%)
PTPN4	NP_002821.1	B41	30..222	CDD:214604	62/207 (30%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	21/95 (22%)
		FA	324..365	CDD:462582	10/48 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	380..412		12/118 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	430..475		18/68 (26%)
		PDZ_PTPN3-4-like	513..602	CDD:467190	22/161 (14%)
		PTP_DSP_cys	641..914	CDD:475123	77/288 (27%)