Protein Alignment Pez and PTPN3

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: XP_011517190.1
• Gene: PTPN3 / 5774
• HGNCID: 9655
• Length: 934
• Species: Homo sapiens
• Alignment Length: 1257
• Identity: 249/1257 - (19%)
• Similarity: 429/1257 - (34%)
• Gaps: 411/1257 - (32%)

  Fly    16 SKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYLVKGKDKEDEFKW 80
            ::|..:.|:|.|.....|.  .::.:..||..||.|...|.:.:.|:|||::   ..|..|..:|
Human    46 TRSEVICSIHFLDGVVQTF--KVTKQDTGQVLLDMVHNHLGVTEKEYFGLQH---DDDSVDSPRW 105

  Fly    81 IDLERSLSRQLEKYAAGPKIYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDIYEGRIACDIRTAI 145
            ::..:::.:|| |......::.|||.:: .....|..|.||..||||||.||.|||:.|.:.:|:
Human   106 LEASKAIRKQL-KGGFPCTLHFRVRFFI-PDPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAV 168

  Fly   146 LLALYCRQAEYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAHLSQSQ 210
            :||.|..|:.:..|........||..|..:|..     |:|.:.:   ||.|.:|.  :.|.||:
Human   169 VLASYAVQSHFGDYNSSIHHPGYLSDSHFIPDQ-----NEDFLTK---VESLHEQH--SGLKQSE 223

  Fly   211 AEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNADNGRQY-----FPWKEFHTVTI 270
            ||..||...:.|:.||.|..:.:|....||::|:|..|:.|.    |:|     :||.....::.
Human   224 AESCYINIARTLDFYGVELHSGRDLHNLDLMIGIASAGVAVY----RKYICTSFYPWVNILKISF 284

  Fly   271 DKRTIKI--EQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRYIDTATPSSLGSGADAE 333
            .::...|  .|.:.:....|| :|......:.:..||..:..|.||
Human   285 KRKKFFIHQRQKQAESREHIV-AFNMLNYRSCKNLWKSCVEHHTFF------------------- 329

  Fly   334 SGPLGVDSVGYVDYDYNEAAAAEQLQQHHQQQQHMQQQQQIQQQQMISSNISLATSANQMLGQSS 398
                                         |.::.:.|::.:..|....
Human   330 -----------------------------QAKKLLPQEKNVLSQYWTM----------------- 348

  Fly   399 SCLDLSNNNLHSSSGMLHHGGSNNNNNNDERERLKAMLPTYRPAPDYETAVQLKYRTPSAEFHNV 463
                                ||.|...:...:..|.::
Human   349 --------------------GSRNTKKSVNNQYCKKVI--------------------------- 366

  Fly   464 ALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQSH 528
                         |..  |.||.| ..:|...|:.....|                       |.
Human   367 -------------GGM--VWNPAM-RRSLSVEHLETKSLP-----------------------SR 392

  Fly   529 PQPMSPAQAYLELSQRMHMMRHKAPPPYVNRLS-SSSTPDLAVATPRPLQGFRNYVSGSSP---- 588
            ..|::|......|...:...||.:.....|.:: .:.|.|:          |..|....:|
Human   393 SPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDV----------FYTYKGSLAPQDSD 447

  Fly   589 -DLVSNRTLFNGGQYVALPAGGHAGNIPTSSGATMLHQYQYVSHMGHSQPYLPPHGTFENLNMIE 652
             ::..||:                                             ||.  |:|:  |
Human   448 SEVSQNRS---------------------------------------------PHQ--ESLS--E 463

  Fly   653 EQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSHKSATPA 717
            ..|                  |.|.:||.|        .|||.|.:::|          .|.:|.
Human   464 NNP------------------AQSYLTQKS--------SSSVSPSSNAP----------GSCSPD 492

  Fly   718 PLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVVPVPAARNASSNNVV 782
            .:.:.|::.     :..|     ..|||     ||...|....             :|.:.::.:
Human   493 GVDQQLLDD-----FHRV-----TKGGS-----TEDASQYYCD-------------KNDNGDSYL 529

  Fly   783 TVTVNSPPDDG----NIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTAS 843
            .:...:|.:||    |:|. |.|:.....:..:.|::|     |.:..|               .
Human   530 VLIRITPDEDGKFGFNLKG-GVDQKMPLVVSRINPESP-----ADTCIP---------------K 573

  Fly   844 LNKSSTVDMITPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSR 908
            ||:...:.:|           :..::|.:|......                         |:..
Human   574 LNEGDQIVLI-----------NGRDISEHTHDQVVM-------------------------FIKA 602

  Fly   909 SKTPDKQKSATLGREKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQI 973
            |:....::.|.:.|.:|..:....|       ::|:||  ..:...:....|..|...:..:.|
Human   603 SRESHSRELALVIRRRAVRSFADFK-------SEDELN--QLFPEAIFPMCPEGGDTLEGSMAQ- 657

  Fly   974 LDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVN 1038
            |.:.|....:.::||::.:::.......|.|.:|..||...:.||||..||.|....|    |:|
Human   658 LKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNED----YIN 718

  Fly  1039 ASSISATVGTKQ--RFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQR---- 1097
            ||.::..:....  ..||..|.|. |.|...|||.||:..:.|:|.||..........||.
Human   719 ASYVNMEIPAANLVNKYIATQGPL-PHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP 782

  Fly  1098 ---LEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLE 1159
               :..|.|.:..:....|....:.::.:.:..:....:|.:|||..|.:...|.|.:.||:|:.
Human   783 PDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVN 847

  Fly  1160 ELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN---EDLDIPRVIGQL 1221
            .:.|:|:.|           .|||:||..|.||:||.:|.:..:...:.|   ..|||.|   ::
Human   848 YVRSLRVDS-----------EPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVR---KM 898

  Fly  1222 RHQRDSIIPSLAQYKFIYNLLI 1243
            |.||..::.:.:||||:...::
Human   899 RDQRAMMVQTSSQYKFVCEAIL 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619	24/89 (27%)
		FERM_M	112..230	CDD:459788	43/117 (37%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	24/98 (24%)
		PTP_DSP_cys	1036..1246	CDD:475123	60/220 (27%)
PTPN3	XP_011517190.1	B41	52..243	CDD:214604	66/207 (32%)
		FERM_C_PTPN4_PTPN3_like	237..330	CDD:270010	24/145 (17%)
		PDZ_PTPN3-4-like	527..616	CDD:467190	19/145 (13%)
		PTPc-N3	652..925	CDD:350448	78/289 (27%)