Protein Alignment Pez and ptpn13

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: XP_068072003.1
• Gene: ptpn13 / 560883
• ZFINID: ZDB-GENE-070410-72
• Length: 2525
• Species: Danio rerio
• Alignment Length: 1965
• Identity: 352/1965 - (17%)
• Similarity: 581/1965 - (29%)
• Gaps: 819/1965 - (41%)

  Fly    36 CTISSESKGQECLDNVCQRLLIQQPEFFGLRYLVKGKDKEDEFKWIDLERSLSRQL-EKYAAGPK 99
            |.:.:..|  :.||.|...:.:.:...|.|.||     |:|||.:::.:..||:.. :.:...||
Zfish   617 CDVKAVCK--DVLDMVVAHIGLVEHHLFSLAYL-----KDDEFYFVESDAKLSKVAPDGWKDDPK 674

  Fly   100 ---------IYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDIYEGRIACDIRTAILLALYCRQAE 155
                     ::||:: :....|..:....|:..|:|||:.||.|.|:.||:..|::||....|||
Zfish   675 KKKTDVIFNLFLRIK-FFQDDVSLIQHTMTKHQYYLQLRKDILEERVRCDLENAMILASLALQAE 738

  Fly   156 YDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAHLSQSQAEEMYIQCCQ 220
            :..||.:...|.|.:....||..:....:..::.|    |:.:..:...:.|:.:||..:::.||
Zfish   739 FGDYQTELHGKTYFRTEHYLPAPVLDKIDQTTIKE----ELPKLHSSYYNASEQEAELEFLKVCQ 799

  Fly   221 QLEGYGE--ERFAAKDTLGNDLLLGLAINGMVV-NADNGRQ----YFPWKEFHTVTIDKRTIKIE 278
            :|..||.  .|...:......::||:...|::: ...||.:    .|||::...::..|:.|.:
Zfish   800 RLPEYGVHFHRVLPEKRSLTGIMLGIYSKGVLIFEVLNGNRTPVLRFPWRDTKKISFTKKKICL- 863

  Fly   279 QNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFF-----------KRYIDTATPSSL----GS 328
            ||..||   |...|......|.:|..:|..:|:||.           .:.::.:..|||    |.
Zfish   864 QNTSDG---IKHLFQTDSQKTCQYLLQLCSAQYKFHLHMKARQNNQELQELENSPLSSLQYSDGM 925

  Fly   329 GA---DAESGPLGVDSVGYVDYDYNEAAAAE--------------------QLQQHH------QQ 364
            ||   ...|.|.....:.|.:...::::::.                    :.:.||      :.
Zfish   926 GAVSLSPSSEPELYKRMSYSEMSLSKSSSSRVSVPSEPPYPGFSSSSNPRMKSRSHHNLGQLPES 990

  Fly   365 QQH------MQQQQQIQQQQMISSNISLATSANQML-------------------------GQSS 398
            .:|      .|.|..:.:.|:::|:...|.|....:                         ..||
Zfish   991 PEHRMVPFSSQSQSSMARSQVLASSHQRANSDTGSIAVARQQESLSVDDSPRWSPKSLKKESDSS 1055

  Fly   399 SCLDLSNN-----NLHSSSGMLHHGGSNNNNNNDERERLKAMLPTYRPAPDYETAV-----QLKY 453
            ||.|....     ::| |||:.....|:....:..:::::|:     |:|:.|...     .:||
Zfish  1056 SCEDTGQAYVVGVSMH-SSGVPSTPASSIGITDSLKKKVQAL-----PSPEREIQTVNLKKDVKY 1114

  Fly   454 R-----------------------TPS--AEFHN------------------------VALAMAA 469
            .                       ||.  |:.:.                        |.:..:|
Zfish  1115 GLGFQVVGGESSGRQDLGTFISSITPGGPADLNGLLKPGDRLLSVNDVSLESLSHTTVVEMLQSA 1179

  Fly   470 PGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQH-----QPQSH- 528
            |.:.....|||        .|.|         :||  .|:.| ||:....|.|.     ..:.|
Zfish  1180 PDDVSLVVSQP--------KERL---------FPD--SPSGA-HHYNPATQIQELDMDSSSEDHT 1224

  Fly   529 --PQP------MSPAQAYLELS-------------QRMHMMR-HKAPP---------------PY 556
              |.|      .||.|:..:.|             |:.|:.. ||..|               |.
Zfish  1225 RSPSPPFTASKTSPPQSIRQGSISSQDSKTESAGLQQTHLNGFHKNIPMEGPVAAQALPADIKPS 1289

  Fly   557 VNRLSSSSTPDL----AVATPRPLQ------------------------------GFRNYVSGSS 587
            :..:..:..|..    |...|:.|:                              .....:|.||
Zfish  1290 IEAMPPALPPKTRKAKAADVPKELEYSDRGDSDMDEDTYSNSQDKLKTKKGVSPITITETLSASS 1354

  Fly   588 PDL-------------------------------VSNRTLFNGGQYV--ALPAGGH--------- 610
            ||:                               .||.:|.:||.||  .:|.|..
Zfish  1355 PDVNSLHPGDLFDIELSKIDSSLGISVTVLFGKGGSNTSLKHGGIYVKGVIPKGAAEQDGRIKKG 1419

  Fly   611 ----AGNIPTSSGAT------MLHQYQYVSH--MGHSQP-------YLPPHGTFENLNMIEEQPS 656
                |.|..:..|||      ||.....|.|  |...||       .|.|.||.|..|...|:||
Zfish  1420 DRVVAVNGKSLEGATHKQAVEMLRDTGQVVHLLMERGQPPKDSIHAPLTPQGTSEPQNKTVEEPS 1484

  Fly   657 I-------------------------------------------MSQLRQSAMSQAAAAA----A 674
            .                                           |.::::....|.||.:    .
Zfish  1485 APEKEYNFITADNTFDVALLKNTSGLGFSFSREEIIPGEPLGSSMVRVKKLFPGQPAAESGRIKV 1549

  Fly   675 GSVVTQSSPT--------------------------LPPSGYRSSVPPPASSPLPPP-------V 706
            |.|:.:.:.|                          .|..|....:....::|:|.|       .
Zfish  1550 GDVILRVNQTPLKGLSQHEVISALRGTGQEVTLHLCRPEQGILPEMDTAITTPVPSPRKQAHLQP 1614

  Fly   707 VASSHKSATPAPLQRSLVNGSIEPIYENVPL--PQRASGGSSGAANTEAMRQ-RASSIQSAPGVV 768
            .||...|::|...||.|  |.:|...|.:.|  |.|....|....|.|.... ||::::......
Zfish  1615 QASPRTSSSPQESQRLL--GPVEEALERLLLKSPSRRDSYSDSTDNDELEEAFRAANLERDSSAY 1677

  Fly   769 PVPAAR--------------------------------NASSNNVVTV-------TVNSPPD--- 791
            ..||.|                                |:||..:...       .:|..||
Zfish  1678 QTPAERVSYEDEMDDTVQSAYYSSRQSMARSEDSRSDVNSSSIRISASPALPEGDLLNPSPDPLP 1742

  Fly   792 -----------------------------------------------------------DGNIKK 797
                                                                       ||.::.
Zfish  1743 PPLPNPVNLSLPEHEDLIPEVELKVSLVKSDKGSLGFTLTKGTDENCYIHDIIQDPAKGDGRLRP 1807

  Fly   798 YGADRAA-----------STELLFLEPQAPKRTNRA-------------ASAAPD---------- 828
              .||..           .||::.|...|||..:..             |...||
Zfish  1808 --GDRMIMVNNTDVSGMNHTEVVNLVRAAPKVVDLVVGRILEPPKPPIEAHLLPDITFQCHDESL 1870

  Fly   829 -----------MGATPPPRQHRSTASLNKSST--VDMI-----TPAGD-TLQQ-----QFSAMNL 869
                       :|..........:|:..:.|.  :|:|     .|..| ||.:     |.|..||
Zfish  1871 GLVLDGGSDSALGVLYVKEIFPGSAAFEEGSLRHLDIIHYINGVPTQDLTLSESRRLLQLSLRNL 1935

  Fly   870 SA---------------------NTSASTSSMFNSTLDTT------------------------- 888
            |.                     |.|...|...|..|.::
Zfish  1936 SLKATRDGKPVFPDEEEISLLNNNISPKVSQSMNGYLHSSENNELEALSGICPAEEQIVKLELEK 2000

  Fly   889 ---------------------------------------------------SSSAASKDLKRKKR 902
                                                               |.:.|...:::.|.
Zfish  2001 PPAGGLGFSVIGGERGIFVKSVTPGGTADIAGTLQVGDRLLKVNDDLMIGVSHAKAVTTIRKAKG 2065

  Fly   903 WNFLSRSKTPDKQKSATLG------------REKATTAGQHSKLAAKLKLAQ------------- 942
            ...|..|:.||:..:..||            .:.:..:|..:||....:.:|
Zfish  2066 LVQLIVSRPPDQMPNTYLGFLPLKSSTVNGNNDVSEDSGVKTKLQTPSEQSQSSSPPPLPPIDYD 2130

  Fly   943 ----------------------DDLNLPN---------RWS-------TGVNKPQPISGRYSKDK 969
                                  |..:||.         .|.       ...:.||..||...:|:
Zfish  2131 TGSLEKRKGTDTSADLSEDTDCDGSSLPEDSPETSRKAEWKEENVDAPLNDSAPQSSSGPLDEDE 2195

  Fly   970 LCQ--------------------ILDQKLSDSQL------------------------------F 984
            :..                    :.:::|:...|                              .
Zfish  2196 ITWGSDDLPIENINSKFTEDGPIVTEEELTSLPLVKVVPDGHYTSTNLNTIVRMMRGLIEQKVPL 2260

  Fly   985 MEFERIPKRREHALYECAL--LEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATVG 1047
            .|||.:...|  .|.||.:  .:||:.||...|.:|:|..||.|    .|..||:||:.|...|.
Zfish  2261 QEFENLQNLR--PLDECLIGQTKENKKKNRYKNIVPFDTTRVLL----GNDGGYINANFIKMAVK 2319

  Fly  1048 TKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMS--------YIP--RNSHQRLEFGQ 1102
            .:...||..|.|. |.|:..|||.|||....::..:|:::.        |.|  ..|.|.:: .:
Zfish  2320 DESFMYIACQGPL-PTTLGDFWQMVWEQKSNVIAMMTQEVEGGKVKCQRYWPDTPRSPQMVD-DR 2382

  Fly  1103 FQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLA 1167
            .||.....|..|......:.|..|.:...:.|.:|.|..|.:...|......|.|:..:..:.|:
Zfish  2383 LQVTLVKDQHLDNFVIRLIELKDVQTNELQRVTHLNYTGWPDHGTPTQPEQLLTFISYMRHIHLS 2447

  Fly  1168 STQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSL 1232
            .            |::.||..|.||||..:..|::|..:..:.|.||..::..:|.||..::.:.
Zfish  2448 G------------PIITHCSAGIGRSGTLICIDVVLGLISKDADFDISDIVRTMRLQRQGMVQTE 2500

  Fly  1233 AQYKFIYNLLITYLK 1247
            .||.|.|.:::..|:
Zfish  2501 EQYIFCYQVILYVLR 2515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619	19/80 (24%)
		FERM_M	112..230	CDD:459788	34/119 (29%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	25/109 (23%)
		PTP_DSP_cys	1036..1246	CDD:475123	56/219 (26%)
ptpn13	XP_068072003.1	Protein Kinases, catalytic domain	48..225	CDD:473864
		Ubl1_cv_Nsp3_N-like	600..694	CDD:475130	19/84 (23%)
		B41	605..809	CDD:214604	53/203 (26%)
		FERM_C_PTPH13	805..905	CDD:270008	24/103 (23%)
		PDZ1_PTPN13-like	1102..1193	CDD:467285	12/98 (12%)
		PTN13_u3	1189..1366	CDD:465189	34/196 (17%)
		PDZ2-PTPN13_FRMPD2-like	1364..1455	CDD:467254	19/90 (21%)
		PDZ3_PTPN13_FRMPD2-like	1498..1587	CDD:467181	7/88 (8%)
		PDZ4_PTPN13-like	1762..1845	CDD:467182	10/84 (12%)
		PDZ5_PTPN13-like	1856..1942	CDD:467183	16/85 (19%)
		PDZ5_DrPTPN13-like	1995..2072	CDD:467273	4/76 (5%)
		PTPc-N13	2281..2514	CDD:350445	68/250 (27%)