Protein Alignment Pez and Ptpn3

DIOPT Version :9

• Sequence 1: NP_001260127.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: XP_006538160.1
• Gene: Ptpn3 / 545622
• MGIID: 105307
• Length: 935
• Species: Mus musculus
• Alignment Length: 1259
• Identity: 261/1259 - (20%)
• Similarity: 430/1259 - (34%)
• Gaps: 429/1259 - (34%)

  Fly    30 TSSTVDCTI------------SSESKGQECLDNVCQRLLIQQPEFFGLRYLVKGKDKEDEFKWID 82
            |.|.|.|:|            :.:..||..||.....|.:.:.|:|||::   |.|..|..:|::
Mouse    47 TRSEVICSIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVTEKEYFGLQH---GDDPVDSPRWLE 108

  Fly    83 LERSLSRQLEKYAAGPKIYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDIYEGRIACDIRTAILL 147
            ..:.|.:|| |......::.|||::: .....|..|.||..||||||.|:.|||:.|.:.:|::|
Mouse   109 ASKPLRKQL-KGGFPCTLHFRVRYFI-PDPNTLQQEQTRHLYFLQLKMDVCEGRLTCPLNSAVVL 171

  Fly   148 ALYCRQAEYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAHLSQSQAE 212
            |.|..|:.:..:........||..|..:|..     |||.:.:   ||.|.:|.  :.|.||:||
Mouse   172 ASYAVQSHFGDFNSSIHHPGYLADSQFIPDQ-----NDDFLSK---VESLHEQH--SGLKQSEAE 226

  Fly   213 EMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNADNGRQY-----FPWKEFHTVTIDK 272
            ..||...:.|:.||.|....:|....||::|:|..|:.|.    |:|     :||     |.|
Mouse   227 SCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVY----RKYICTSFYPW-----VNI-- 280

  Fly   273 RTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRYIDTATPSSLGSGADAESGPL 337
                                           .|::..:.|||
Mouse   281 -------------------------------LKISFKRKKFF----------------------- 291

  Fly   338 GVDSVGYVDYDYNEAAAAEQLQQHHQQQQHMQQQQQIQQQQMISSNISLATSANQMLGQSSSCLD 402
                                        .|.:|:|...::.:::.|:....|...:.   .||::
Mouse   292 ----------------------------IHQRQKQAESREHIVAFNMLNYRSCKNLW---KSCVE 325

  Fly   403 LSNNNLHSSSGMLHHGGSNNNNNNDERERLKAMLPTYRPA-PDYETAVQLKYRTPSAEFHNVALA 466
                         ||...          :.|.:||..:.. ..|.|   |..|.|....:|....
Mouse   326 -------------HHSFF----------QAKKLLPQEKNVLSQYWT---LGSRNPKKSVNNQYCK 364

  Fly   467 MAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQSHPQP 531
            ....|.         |.||.|...      ::..|....:.|                  |...|
Mouse   365 KVIGGM---------VWNPVMRRS------LSVERLETKSLP------------------SRSPP 396

  Fly   532 MSPAQAYLELSQRMHMMRHKAPPPYVNRLS-SSSTPDLAVATPRPLQGFRNYVSGSSPDLVSNRT 595
            ::|......|...:...||.:.....|.:: .:.|.|:......||.
Mouse   397 ITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGPLS------------------ 443

  Fly   596 LFNGGQYVALPAGGHAGNIPTSSGATMLHQYQYVSHMGHSQPYLPPHGTFENLNMIEEQPSIMSQ 660
                               |..|.:.:        ...||     ||.  |:|:  |..|
Mouse   444 -------------------PKDSDSEV--------SQNHS-----PHR--ESLS--ENNP----- 467

  Fly   661 LRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSHKSATPAPL-QRSLV 724
                         |.|.:||.|        .|||.|.:::|          .|.:|..: ||.|.
Mouse   468 -------------AQSCLTQKS--------SSSVSPSSNAP----------GSCSPDGVDQRFLE 501

  Fly   725 NGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVVPVPAARNASSNNVVTVTVNSP 789
            :      |..|         :.|....:|.:..........|.:               |.:...
Mouse   502 D------YHKV---------TKGGFVEDASQYYCDKSDDGDGYL---------------VLIRIT 536

  Fly   790 PDD----GNIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTV 850
            ||:    |...|.|.|:.....:..:.|::|     |.:..|               .||:...:
Mouse   537 PDEEGRFGFNLKGGVDQKMPLVVSRINPESP-----ADTCMP---------------KLNEGDQI 581

  Fly   851 DMITPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQ 915
            .:|           :..::|.:|......                         |:..|:....:
Mouse   582 VLI-----------NGRDISEHTHDQVVM-------------------------FIKASRESHSR 610

  Fly   916 KSATLGREKATTAGQHSKLAAKLKLAQDDLN--LPNRWSTGVNKPQPISGRYSKDKLCQILDQKL 978
            :.|.:.|.||.      :..|::: ::|:|:  .|....     |....|..|.:...::|.:.|
Mouse   611 ELALVIRRKAV------RSLAEIR-SEDELSQLFPEAMF-----PACPEGGDSLEGSMELLKKGL 663

  Fly   979 SDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSI- 1042
            ....:.::||::.:::.......|.|.:|..||...:.||||..||.|....|    |:|||.:
Mouse   664 ESGTVLIQFEQLYRKKPGLAVSFAKLPQNLDKNRYKDVLPYDTTRVLLQGNED----YINASYVN 724

  Fly  1043 ----SATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMSYIPRNSHQR------ 1097
                :|.:..|   ||..|.|. |.|...|||.||:..:.|||.||..........||.
Mouse   725 MEMPAANLVNK---YIATQGPL-PNTCAQFWQVVWDQKLSLVVMLTTLTERGRTKCHQYWPDPPD 785

  Fly  1098 -LEFGQFQVYQEFSQTTDRCT----TIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDF 1157
             ::.|.|.:.   .||.| ||    :.::.:.:..:....:|.:|||..|.:...|.|.:.||:|
Mouse   786 IMDHGIFHIQ---CQTED-CTIAYVSREMLVTNTETGEEHTVTHLQYVAWPDHGVPDDSSDFLEF 846

  Fly  1158 LEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHN---EDLDIPRVIG 1219
            ::.:.|:|:           ...|.|:||..|.||:||.:|.:..:..::.|   ..|||.|
Mouse   847 VKYVRSLRV-----------DGEPALVHCSAGIGRTGVLVTMETAMCLIERNLPVYPLDIVR--- 897

  Fly  1220 QLRHQRDSIIPSLAQYKFIYNLLI 1243
            ::|.||..::.:.:||||:...::
Mouse   898 KMRDQRAMMVQTSSQYKFVCEAIL 921

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_001260127.1	B41	26..230	CDD:214604	67/211 (32%)
		FERM_N	26..93	CDD:286467	21/74 (28%)
		FERM_M	114..230	CDD:278785	42/115 (37%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	20/96 (21%)
		Y_phosphatase	1007..1243	CDD:278528	76/254 (30%)
		PTPc	1009..1243	CDD:238006	75/252 (30%)
Ptpn3	XP_006538160.1	B41	53..244	CDD:214604	64/205 (31%)
		FERM_C_PTPN4_PTPN3_like	238..331	CDD:270010	29/211 (14%)
		PDZ_signaling	530..617	CDD:238492	19/157 (12%)
		PTPc-N3	653..926	CDD:350448	82/295 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900