DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pez and Grip

DIOPT Version :9

Sequence 1:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_572285.2	Gene:	Grip / 50391	FlyBaseID:	FBgn0029830	Length:	1058	Species:	Drosophila melanogaster

Alignment Length:	949	Identity:	181/949 - (19%)
Similarity:	270/949 - (28%)	Gaps:	388/949 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 QQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDERERLK 433
            |.|||.||||..|.|.|.                    |.|      ||
  Fly    23 QDQQQQQQQQQESHNNSF--------------------NGH------HH---------------- 45

  Fly   434 AMLPTYRPAPDYETAVQLKYRTPSAEFHNVALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMT 498
                     |..:||:        |...:|..|| :|..:..:|..|:                .
  Fly    46 ---------PPTDTAL--------APMLSVDRAM-SPAQSEDSGLAPE----------------R 76

  Fly   499 AHRYPDVAQPAAALHHHINLYQAQHQPQSHP------QPMSPAQAYLELSQRMHM---------- 547
            ...|..:..|..|||..|..  |:....|:|      .|:..|..:|....|:|.
  Fly    77 GTTYATITLPRNALHLAITF--AERNDLSYPPVVGSLNPVGHAADFLAPGDRLHQIDGISTIGLS 139

  Fly   548 ---------------------MRHKAPPPYVNRLSSSSTPDLAVATPR--------PLQGFRNY- 582
                                 :.:..|...|::.|...|..||..|..        .|:|..:|
  Fly   140 NQKVMNMLCAGGSDACPAIVEIEYSLPECTVSQNSLCVTSKLAQITVERESGCLGLTLRGGADYP 204

  Fly   583 -----VSGSSP----------------DLVS--NRTLFNGGQYVALPAGGHAG---NIPTSSGAT 621
                 |....|                |.||  .:||....|.:  ..|||..   |:......:
  Fly   205 LIVTHVRPHGPVYKTGRIKPGDRLLRVDNVSLIGKTLAEAQQII--KCGGHVSGYTNLTIEYDVS 267

  Fly   622 MLHQYQYVSHMGHSQPYL----------------------PPHG----TFENLNMIEEQPS--IM 658
            ::...::  .||   |.|                      |..|    |..:...|||...  |.
  Fly   268 VVQSVEF--SMG---PLLIEIERPMNDKLGLVLCNYTAAVPASGSGSSTPSSGEKIEESAGVFIA 327

  Fly   659 SQLRQSAMSQAAAAAAGSVV----------TQSSP--------TLPPSGYRSSVPPPA------- 698
            |.|..|...:..|.:.|..|          |..||        |....||......||
  Fly   328 SILPASIADRCGALSVGDQVLSIDDTMIEHTAFSPDEVMTILDTSTGRGYTQMQIMPAHALARRG 392

  Fly   699 ----SSPLPPPVVASSHKSATPAPLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRAS 759
                .||........|.||:|....::.....|..|: ||   |...:.||:|.:........:|
  Fly   393 HTTLGSPKYSFSTLESRKSSTAGRQRQRFARKSSLPL-EN---PACGTPGSTGGSMGTGGIHGSS 453

  Fly   760 SIQSAPGV-----VPVPAARNASSNNVVTVTVNSPPDDGNI------------------------ 795
            |:....|:     .||....:..:..:::.||:.....|.:
  Fly   454 SLGMGLGLCRAESFPVLLDCSHGAGIILSETVSGSGGSGAVAIAQIVPDSVADRSGCIQAGDRIV 518

  Fly   796 ---KKYGADRAASTELLFLEPQAPKRTNRAASAAP----------DMGATPPP----------RQ 837
               |.|..|.||..:||    :.....|.|::..|          ||.....|          |.
  Fly   519 AINKMYSLDAAAMRQLL----EGGSSRNGASNGTPANWLELEIEFDMPDAVVPASGVFSVKLLRA 579

  Fly   838 HRSTASLNKS---------STVDMITPA--------GDTL-------QQQFSAMNL------SAN 872
            .:....|:.|         |.|.|.:||        ||.|       .|.|:...|      |.|
  Fly   580 GKCGLGLSVSGSSHGGLVISDVKMGSPAHRSGSLRSGDILLAVDQHPVQHFNVDALLKEEGRSQN 644

  Fly   873 TSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSR-----SKTPDKQKSATLGREKAT------ 926
            .|.|:|.....|            :||....:||..     |..|....:..:|...:|
  Fly   645 PSHSSSDFTTLT------------IKRIVLPDFLPMSSPIYSNCPASGINLGMGMGVSTSTDHDL 697

  Fly   927 ------TAGQHSK-LAAKLKLAQ---------DDLNL-----------------PNRWSTGVNKP 958
                  |||:::. ::.|.:..|         ||.:|                 .|.||||||..
  Fly   698 YSSAYVTAGKYADCVSLKSRTPQPDYFRVPSMDDASLQSVQLRSGSGSNGGNQAANSWSTGVNSR 762

  Fly   959 QPISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNR 1023
            ..::...::....::.:::....|::..:|    ...:|..:|..|.            |..:|:
  Fly   763 SYVAPPNTQSLTTELPEEEDEQEQMYPGYE----LNRYASVDCTALP------------PPMENK 811

  Fly  1024 VRLTPCRDNRHGYVNASSISATVGTK--QRFYIVAQSPQ 1060
            |         :|.. |||.|.:.|:.  |..:.|...|:
  Fly   812 V---------YGSA-ASSSSKSSGSSLHQIIFTVRLEPK 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_001260127.1	B41	26..230	CDD:214604
		FERM_N	26..93	CDD:286467
		FERM_M	114..230	CDD:278785
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		Y_phosphatase	1007..1243	CDD:278528	12/56 (21%)
		PTPc	1009..1243	CDD:238006	12/54 (22%)
Grip	NP_572285.2	PDZ	82..147	CDD:294084	13/66 (20%)
		PDZ_signaling	183..254	CDD:238492	14/72 (19%)
		PDZ_signaling	278..375	CDD:238492	19/96 (20%)
		PDZ	496..>521	CDD:294084	0/24 (0%)
		PDZ_signaling	571..658	CDD:238492	20/98 (20%)
		PDZ_signaling	832..913	CDD:238492	2/9 (22%)
		PDZ_signaling	973..1055	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900