DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pez and Ptpn13

DIOPT Version :9

Sequence 1:NP_001260127.1 Gene:Pez / 33882 FlyBaseID:FBgn0031799 Length:1252 Species:Drosophila melanogaster
Sequence 2:XP_038948202.1 Gene:Ptpn13 / 498331 RGDID:1563360 Length:2465 Species:Rattus norvegicus


Alignment Length:1970 Identity:349/1970 - (17%)
Similarity:581/1970 - (29%) Gaps:834/1970 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    24 VHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYLVKGKDKEDEFKWIDLERSLS 88
            |:.:|.:...::.|..:::..::..|.|...:.:.:...|.|..|     ||:|:.::|.:..|:
  Rat   567 VNIMLLSGQRLELTCDTKTVCRDVFDMVVAHIGLVEHHLFALATL-----KENEYFFVDPDLKLT 626

  Fly    89 RQL-EKYAAGPK----------IYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDIYEGRIACDIR 142
            :.. |.:...||          ::.|::.:: ..|..:....|...|:|||:.|:.|.||.||..
  Rat   627 KVAPEGWKEEPKRKGKAAVDFTLFFRIKFFM-DDVSLIQHSLTCHQYYLQLRKDLLEERIHCDDE 690

  Fly   143 TAILLALYCRQAEYDSYQGDKQSKDYLKKSLVLP-RNMQGLANDDSMLEGLIVEVLQQQAGIAHL 206
            .::|||....||||..||.:.....|.:....|| |.|:.|  |.|.::..:.::....||   .
  Rat   691 ASLLLASLALQAEYGDYQPEVHGLSYFRLEHYLPARVMEKL--DMSYIKEELPKLHNTYAG---A 750

  Fly   207 SQSQAEEMYIQCCQQLEGYGE--ERFAAKDTLGNDLLLGLAINGMVV-NADNGRQ----YFPWKE 264
            |:.:.|..:::.||:|..||.  .|...:......:|||:...|::| ...||.:    .|||:|
  Rat   751 SEKETELEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRALVLRFPWRE 815

  Fly   265 FHTVTIDKRTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRY-----------I 318
            ...::..|:.|.: ||..||   |..:|....:...:|..:|..|||||..:.           :
  Rat   816 TKKISFSKKKITL-QNTSDG---IKHAFQTDSSKACQYLLQLCSSQHKFQLQMRARQSNQDAQDL 876

  Fly   319 DTATPSSLGSGADAESG-----------------------PLGVDS----------------VGY 344
            :.|:..||...|::..|                       ||.|.:                :..
  Rat   877 ERASFRSLNLQAESVRGFNVGRAISTGSLASSTFNKLAVRPLSVQAEILKRLSCSEWSLYQPLQN 941

  Fly   345 VDYDYNEAAAAEQ----------------LQQHHQQQQHMQQ----------------------- 370
            ...:.|:.|:.|:                |..|.:|..:|:.                       
  Rat   942 SSKEKNDKASWEEKPRGMSKSYHDLSQASLCPHRKQVINMESLPQAFAELVGKPLYPMARSDTES 1006

  Fly   371 ---QQQIQQQQMISS-------------------------NISLATSANQMLGQSSSCLDL-SNN 406
               ..|:...:.::|                         .:||.:|     |:|||.:.. .|:
  Rat  1007 LAGLPQLNNSKSVASLNRSPERRSHESDSSVEDPGQAYVVGMSLPSS-----GKSSSQVPFKDND 1066

  Fly   407 NLH-------------------------------------------------------------- 409
            :||                                                              
  Rat  1067 SLHKRWSTVSSPEREITLVNLKKDLKHGLGFQIVGGGKMGRLDLGVFISAVTPGGPADLDGCLKP 1131

  Fly   410 ----------SSSGMLHHGGSNNNNNNDERERLKAMLPTYRPAPDYETAVQLKYRTPSAEFHNVA 464
                      |..|:.||...:...|..|...|....|..:|.           :.||...|   
  Rat  1132 GDRLISVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPT-----------KVPSTPVH--- 1182

  Fly   465 LAMAAPGNAYY--------------AGSQPDVHNPGMHNENLLYGHMTAHRYPDVA------QPA 509
               .|.|...|              :..||....|..|.....:|..:..|...::      :.|
  Rat  1183 ---FANGMKNYTKKPSSMQDSAMDPSEDQPWPRGPLRHVPESPFGLSSGLREGSLSSQDSRTESA 1244

  Fly   510 AALHHHINLYQAQH-------QPQSHPQPMSPAQAYLELSQRMHMMRHKAP-------------- 553
            :....|:|.:...|       :|| |..|..|..:  :::::.....:::|              
  Rat  1245 SLSQSHVNGFFTSHLGDRGWQEPQ-HSSPSPPVTS--KITEKTFSDSYRSPARRQGTCDVTELPG 1306

  Fly   554 --------PPY-------------------VNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDL- 590
                    |.|                   .:::|.::.|.   .:|.|...|...::.:...| 
  Rat  1307 CADSDIDDPTYSSSQDRQAPKQEPSSPLKASDKMSFAAFPG---PSPEPGDAFEVELAKTDGSLG 1368

  Fly   591 VSNRTLF----------NGGQYV--ALPAGG-------HAG------NIPTSSGAT--------- 621
            :|...||          :||.||  .:|.|.       |.|      |..:..|||         
  Rat  1369 ISVTVLFDKGGVNTSVRHGGIYVKAVIPNGAAETDGRIHKGDRVLAVNGVSLEGATHKQAVETLR 1433

  Fly   622 ----MLH--------------------------------------------QYQYV--------- 629
                ::|                                            .|.:|         
  Rat  1434 NTGQVVHLLLEKGQSPTSRERDPASPRCPTPDQDAQSQAPEKMEKQTAHVKDYSFVTEDNTFEVK 1498

  Fly   630 -----SHMGHS-------------------------QP--------------------------- 637
                 |.:|.|                         ||                           
  Rat  1499 LFKNSSGLGFSFSREDNLTPELINGSIVRVKKLFPGQPAAESGKINVGDVILKVNGAPLKGLSQQ 1563

  Fly   638 -----------------------YLP------------PHGTFENLNMIEEQPSIMSQLRQSAMS 667
                                   .||            |...|.|......|||.:| :.|.|.|
  Rat  1564 DVISALRGTAPEVSLLLCRPAPGVLPEVNTALLTPLHSPAHAFLNSRKEHSQPSPLS-VEQCASS 1627

  Fly   668 Q---------------------------------AAAAAAGSVV-----------TQSSPT---- 684
            .                                 .|||...:|:           :|..|.    
  Rat  1628 DENGLSGQSKRQCKPPSRRESYSDHSDSGEEESVRAAAKMPNVIPLSAFAPEALRSQGEPASTMF 1692

  Fly   685 -LP------PSGYRSSVPPPAS-SP----LPPPVVASS--------------HKSATPAPLQRSL 723
             ||      |....|.:|.|.. ||    .||...|.|              ||......|:..|
  Rat  1693 YLPRKIPGKPESESSRLPHPLDVSPGQIRQPPAECAPSDSPGKHLTHLASQLHKEENMTALKNDL 1757

  Fly   724 VN--------------------GSIE------------PIYENVPLPQRASG------------- 743
            .|                    ||:.            .:::.:..|.:..|             
  Rat  1758 GNHLEDSELEVELLITLVKSEKGSLGFTVTKGSQSIGCYVHDVIQDPAKGDGRLRPGDRLVKVND 1822

  Fly   744 -GSSGAANTEAMRQRASSIQSAPGVVPVPAAR--------------------------------- 774
             ..:...:|:|:    :.:::||..|.:...|                                 
  Rat  1823 ADVTNMTHTDAV----NLLRAAPKTVRLVIGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGG 1883

  Fly   775 NASSNNVVTVTVNSPPDD----------------GNIKKYG-----ADRAASTEL--LFLE---- 812
            ..|.:.||.::..:|...                ..:..:|     |:||....|  :.|:    
  Rat  1884 RGSPHGVVYISDINPRSAAAVDCSLQLLDIIHYVNGVSTHGMTLEEANRALDLSLPSVVLKVTRD 1948

  Fly   813 --PQAPKRTNRAASAAPDMGAT----------PPPRQHRSTASLNKSSTVDMITPAGDTLQ---- 861
              |..|..|..|.||...:.|.          |.....:|.:.:|.......:.|.|..|.    
  Rat  1949 GCPVVPCSTRSAISALRPLEANGLSSMEPYGQPALTPKKSFSKVNGDGASGAMCPGGKGLSSPRK 2013

  Fly   862 --------QQFS-------------------------------AMNLSANTSASTSSMFNSTLDT 887
                    :.||                               |.||...|.||..:.....|.|
  Rat  2014 KSADLMEARDFSFQESDSRDDDVYDDPQEAEVIQSLLDVVDEEAQNLLNQTKASRRACSPDPLRT 2078

  Fly   888 TSSSAASKDLK---------------------RKKRWNFL---SRSKTPDKQKSATLGREKAT-T 927
              :..||:|.:                     .|..:..|   |:.:.|.|:::....||..| |
  Rat  2079 --NGEASEDGEDTDCDGSPLPEDVPESVNGGGGKACFASLIQASQEEKPVKEEATQESRESTTET 2141

  Fly   928 AGQHSKLAAKLKLAQDDL-NLPNRWSTGVNKPQPISGRYSKDKLCQ-------ILDQKLSDSQLF 984
            ..:.......|.|..::| .||      |.:..| ||:|:..:|..       :|||.:...:| 
  Rat  2142 TDREDSSKDPLFLTNEELAALP------VVRVPP-SGKYTGTQLQATIRTLQGLLDQGIPSKEL- 2198

  Fly   985 MEFERIPKRREHALYECAL--LEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATVG 1047
               |.:.:.:  .|.:|.:  .:||..||...|.||||..||.|    .:..||:|||.|...||
  Rat  2199 ---ENLQELK--PLDQCLIGQTKENRRKNRYKNILPYDTTRVPL----GDEGGYINASFIRIPVG 2254

  Fly  1048 TKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMS--------YIP--------RNSHQ 1096
            |::..||..|.|. |.|:..|||.|||.:..::..:|:::.        |.|        .|...
  Rat  2255 TQEFVYIACQGPL-PTTVGDFWQMVWEQNSTVIAMMTQEVEGEKIKCQRYWPSILGTTTMANERL 2318

  Fly  1097 RLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEEL 1161
            ||...:.|..:.|       ....:.|..:.:...|.:.:|.:..|.:.:.|......|.|:..:
  Rat  2319 RLALLRMQQLKGF-------VVRVMALEDIQTGEVRHISHLNFTAWPDHDTPSHPEDLLTFISYM 2376

  Fly  1162 NSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRD 1226
            ..:|.:.            ||:.||..|.||||..:..|::|..:..:.:.||..::..:|.||.
  Rat  2377 RHIRRSG------------PVITHCSAGIGRSGTLICIDVVLGLISQDLEFDISDLVRCMRLQRH 2429

  Fly  1227 SIIPSLAQYKFIYNLLITYL 1246
            .::.:..||.|.|.:::..|
  Rat  2430 GMVQTEGQYVFCYQVVLYVL 2449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PezNP_001260127.1 B41 26..230 CDD:214604 54/217 (25%)
FERM_N 26..93 CDD:286467 12/67 (18%)
FERM_M 114..230 CDD:278785 37/118 (31%)
FERM_C_PTPN14_PTPN21 225..317 CDD:270009 29/98 (30%)
Y_phosphatase 1007..1243 CDD:278528 68/251 (27%)
PTPc 1009..1243 CDD:238006 67/249 (27%)
Ptpn13XP_038948202.1 KIND 3..190 CDD:214801
FERM_F1_PTPN13 564..659 CDD:340715 17/97 (18%)
B41 566..774 CDD:214604 55/217 (25%)
PH-like 770..870 CDD:418428 28/103 (27%)
PDZ_signaling 1082..1166 CDD:238492 7/83 (8%)
PTN13_u3 1168..1356 CDD:406898 30/210 (14%)
PDZ_signaling 1356..1444 CDD:238492 18/87 (21%)
PDZ 1493..1583 CDD:214570 5/89 (6%)
PDZ_signaling 1769..1848 CDD:238492 9/82 (11%)
PDZ_signaling 1873..1945 CDD:238492 10/71 (14%)
PTPc-N13 2216..2449 CDD:350445 69/256 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

Return to query results.
Submit another query.