DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pez and ptpn3

DIOPT Version :9

Sequence 1:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	XP_687930.5	Gene:	ptpn3 / 407635	ZFINID:	ZDB-GENE-030131-2934	Length:	839	Species:	Danio rerio

Alignment Length:	1243	Identity:	237/1243 - (19%)
Similarity:	396/1243 - (31%)	Gaps:	476/1243 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYLVKGKDKEDEFKWIDLERSLSRQL 91
            |....:|.:.|::....|....|..|:.|.|.:.::|.::.   .:|.....:|:|..:...:||
Zfish    36 LFPDGTTQNFTVNKHDAGHLLFDLACEHLNIVEKQYFSMQI---SEDTSSSPRWLDPNKPFKKQL 97

  Fly    92 EKYAAGPKIYL--RVRHYVTTGVRHLSDEATRFYYFLQLKSDIYEGRIACDIRTAILLALYCRQA 154
            :   ..|..:|  |||.:: :....|..|.||.:||||::.||.|||:.|.:.:|::||.|..|:
Zfish    98 K---GSPPFFLMFRVRFFI-SDPNSLQHEQTRHFYFLQIRKDICEGRLKCPLSSAVVLASYSVQS 158

  Fly   155 EYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAH--LSQSQAEEMYIQ 217
            |...|..:..: .||.|:..:|.      .|...|  |.||.|..|    |  ||||.||..|:.
Zfish   159 ELGDYNPETPT-GYLSKTHFIPE------QDQEFL--LKVESLHPQ----HKGLSQSDAELCYLN 210

  Fly   218 CCQQLEGYGEERFAAKDTLGNDLLLGLAING------MVVNADNGRQYFPWKEFHTVTIDKRTIK 276
            ..:.|:.||.|...|:|.....:.:|:...|      ::.::     :|||.....::..::...
Zfish   211 TARTLDLYGVELHHAQDASNPAVWVGITSGGVALFCHLICSS-----FFPWINIIKISFKRKRFF 270

  Fly   277 IEQNKLDGG-GSIVGSFIFSEADTARYFWKLTISQHKFFKRYIDTATPSSLGSGADAESGPLGVD 340
            :...:..|. |..|.|.....:...:..|:..:..|.|:.|     .||
Zfish   271 VHLRRKHGELGHHVVSLSMPNSRACKNLWRSCVDHHTFYNR-----KPS---------------- 314

  Fly   341 SVGYVDYDYNEAAAAEQLQQHHQQQQHMQQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSN 405

Zfish   315 ----------------------------------------------------------------- 314

  Fly   406 NNLHSSSGMLHHGGSNNNNNNDERERLKAMLPTYRPAPDYETAVQLKYRTPSAEFHNVALAMAAP 470
               ||:|.:                   :.:|.||.
Zfish   315 ---HSASKL-------------------SSIPLYRK----------------------------- 328

  Fly   471 GNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQSHPQPMSPA 535
                ..|.|  :.||.:.:.::                            .|.:.:|.|.
Zfish   329 ----LVGEQ--MLNPMVRSSSV----------------------------EQLETKSLPS----- 354

  Fly   536 QAYLELSQRMHMMRHKAPPPYVNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDLVSNRTLFNGG 600
                           ::||         :||:.  .:||....|||    ..|..|.|.|
Zfish   355 ---------------RSPP---------NTPNW--RSPRVRHDFRN----PRPSSVDNLT----- 384

  Fly   601 QYVALPAGGHAGNIPTSSGATMLHQYQYVSHMGHSQPYLPPHGTFENLNMIEEQPSIMSQLRQSA 665
                                   ::..||:..             |::.....:|       |..
Zfish   385 -----------------------NEMSYVTES-------------EDVFYTYRKP-------QEE 406

  Fly   666 MSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSH---KSATPAPLQRSLVNGS 727
            ..::.:.:.|..:|.....|                         |   ||.|
Zfish   407 ERRSGSWSHGDDITIEEDDL-------------------------HVWDKSVT------------ 434

  Fly   728 IEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVVPVPAARNASSNNVVTVTVNSPPDD 792
                                                             :..:::.|.: ||..|
Zfish   435 -------------------------------------------------ADGDLLLVRI-SPDQD 449

  Fly   793 G----NIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVDMI 853
            |    |:|. |.|:..        |.|....|.|:.|    |...||        |.:...|.:|
Zfish   450 GKFGFNVKG-GVDQKM--------PLAISHVNLASPA----GRCVPP--------LMEGDQVLLI 493

  Fly   854 TPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQKSA 918
                       :..::|.:|......                         |:..|:....::.|
Zfish   494 -----------NGRDISEHTHQQVVM-------------------------FIKASRESHSKELA 522

  Fly   919 TLGREKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQKLSDSQL 983
            .|.|.|    |...::...|:|.   |.||...|.....|   ||...::.:.: |::.|....|
Zfish   523 LLVRRK----GVSLRVEPTLQLG---LTLPGEISPLSTHP---SGETLEESMAR-LEKGLVTGTL 576

  Fly   984 FMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATVGT 1048
            .:.||::.:::|..|..||...||..||...:.||||..||.|   ::....|:|||.:......
Zfish   577 LLHFEKLYRKKEGMLMSCAKQSENMDKNRYKDVLPYDITRVVL---QEEGDDYINASHVKTEPAG 638

  Fly  1049 KQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQL--------TEDMSYIPRNSHQRLEFGQFQV 1105
            ....||.||.|. |.|...||:.|||.||.:::.|        |:...|.|.....| ::|..||
Zfish   639 CVLQYIAAQGPL-PHTCTHFWRSVWEQDVNVIIMLTTLTERGRTKCHQYWPHPPEVR-DYGYLQV 701

  Fly  1106 YQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQ 1170
            .....:......|.:|.|.:..|.:.||:.:|||..|.:...|.|.:.||||::.:.|:|..|.
Zfish   702 CCHSEECNLAYVTRQLTLTNTQSGQQRSITHLQYVAWPDHGVPEDSSDFLDFVKSVRSMRQESV- 765

  Fly  1171 EVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQY 1235
                      |:::||..|.||:||.:|.:..:..::..:.:....||..:|.||..::.:..|:
Zfish   766 ----------PLMVHCSAGIGRTGVLITMETAMTLMEKEKPVYPLEVITLMREQRAMLVQTSCQF 820

  Fly  1236 KFIYNLLI 1243
            .|:...::
Zfish   821 TFVCEAIL 828

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_001260127.1	B41	26..230	CDD:214604	63/206 (31%)
		FERM_N	26..93	CDD:286467	14/65 (22%)
		FERM_M	114..230	CDD:278785	44/117 (38%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	17/98 (17%)
		Y_phosphatase	1007..1243	CDD:278528	71/243 (29%)
		PTPc	1009..1243	CDD:238006	70/241 (29%)
ptpn3	XP_687930.5	B41	33..223	CDD:214604	63/206 (31%)
		FERM_N	35..98	CDD:286467	13/64 (20%)
		FERM_M	117..223	CDD:278785	44/118 (37%)
		PH-like	217..309	CDD:302622	16/96 (17%)
		PDZ_signaling	439..526	CDD:238492	26/144 (18%)
		PTPc	579..829	CDD:214550	78/266 (29%)
		PTPc	602..828	CDD:238006	70/241 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900