Protein Alignment Pez and Ptp69D

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_524048.2
• Gene: Ptp69D / 39443
• FlyBaseID: FBgn0014007
• Length: 1462
• Species: Drosophila melanogaster
• Alignment Length: 1300
• Identity: 272/1300 - (20%)
• Similarity: 426/1300 - (32%)
• Gaps: 427/1300 - (32%)

  Fly   110 TGVRHLSDEATRFYY---FLQLKSDIYEGRIACDIRTAILLALYCRQAEYDSYQGDKQSKDYLKK 171
            ||..|.::...|.|.   .||...|..:.:|..|:      .|||....|...:...::..:||
  Fly   116 TGQNHSTEFQVRPYLPSKVLQSTPDRIKRKIKQDV------MLYCLIEMYPQNETTNRNLKWLK- 173

  Fly   172 SLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERFAAKDTL 236
                              :|...|.|...:.|:.|:.:...    ...:..|.|.:|....|.|:
  Fly   174 ------------------DGSQFEFLDTFSSISKLNDTHLN----FTLEFTEVYKKENGTYKCTV 216

  Fly   237 GNDLLLGLAINGMVVNADNGRQYFPWKEFHTVTIDKRTIKIE------QNKL-------DGGGSI 288
            .:|  .||.|..              ||.....::...:.|:      .||:       ||...|
  Fly   217 FDD--TGLEITS--------------KEITLFVMEVPQVSIDFAKAVGANKIYLNWTVNDGNDPI 265

  Fly   289 VGSFI-FSEADTARYFWKLTISQHKFF-----KRYI-DTATP-----------SSLGSGADAESG 335
            ...|| ..||.|.      |.:.||.|     ..|| |...|           :|:|:|...:.
  Fly   266 QKFFITLQEAGTP------TFTYHKDFINGSHTSYILDHFKPNTTYFLRIVGKNSIGNGQPTQY- 323

  Fly   336 PLGVDSVGYVDYDYNEAAAAEQLQQHHQQQQHMQQQQQIQQQQMISSNISLATSANQMLGQSSSC 400
            |.|:.::.| |..:                        |.:.:...|..|..|     :|.:...
  Fly   324 PQGITTLSY-DPIF------------------------IPKVETTGSTASTIT-----IGWNPPP 358

  Fly   401 LDLSN-----NNLHSSSG----MLHHGGSNNNNNNDERERLKAMLPTYRPAPDYETAVQ-----L 451
            .||.:     ..:.|.||    ::.......|:.|     |..|....:.|.|||..|:     .
  Fly   359 PDLIDYIQYYELIVSESGEVPKVIEEAIYQQNSRN-----LPYMFDKLKTATDYEFRVRACSDLT 418

  Fly   452 KYRTPSAEFHNVALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRY-----PDVAQPAAA 511
            |...|.:|..|   .....|.|    ::|...:...|::|:..|:..|..:     |:....:..
  Fly   419 KTCGPWSENVN---GTTMDGVA----TKPTNLSIQCHHDNVTRGNSIAINWDVPKTPNGKVVSYL 476

  Fly   512 LH------------------------HHINLYQAQHQPQSHPQPMSPAQAY-LELSQRMHMMRHK 551
            :|                        ||..||::          :||...| :.:|.   :.|||
  Fly   477 IHLLGNPMSTVDREMWGPKIRRIDEPHHKTLYES----------VSPNTNYTVTVSA---ITRHK 528

  Fly   552 --APPPYVNRLSSSSTPD-----------------LAVATPR------PLQGFRNYVSGSSPDLV 591
              ..|...:.|...||||                 |.:..|:      |:..:|.|:...:.|
  Fly   529 KNGEPATGSCLMPVSTPDAIGRTMWSKVNLDSKYVLKLYLPKISERNGPICCYRLYLVRINND-- 591

  Fly   592 SNRTL-----FNGGQYVALPAGGHAGNIPTSSGATMLHQYQYVSHMGHSQPYLP-----PHGTF- 645
             |:.|     .|...|..:    |:.|:..||.        |::.|..|:.:.|     ....|
  Fly   592 -NKELPDPEKLNIATYQEV----HSDNVTRSSA--------YIAEMISSKYFRPEIFLGDEKRFS 643

  Fly   646 ENLNMIEEQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASS 710
            ||.::|.:...|..:                 ..:.:|.|         ..|....:||
  Fly   644 ENNDIIRDNDEICRK-----------------CLEGTPFL---------RKPEIIHIPP------ 676

  Fly   711 HKSATPAPLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTE-AMRQRASSIQSAPGVVPVPAAR 774
                     |.||.|...|     :|:.........||..|| |::...|.::.         .|
  Fly   677 ---------QGSLSNSDSE-----LPILSEKDNLIKGANLTEHALKILESKLRD---------KR 718

  Fly   775 NA--SSNNVVTVTVNSPPDDGNIKKYGADRAA--------STELLFLEPQAPKRTNRAASAAPDM 829
            ||  |..|.:...||.     |:..:.:.|..        |....|||.....|.|
  Fly   719 NAVTSDENPILSAVNP-----NVPLHDSSRDVFDGEIDINSNYTGFLEIIVRDRNN--------- 769

  Fly   830 GATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMN-----LSANTSASTSSM--------- 880
                        |.:..|...|:||||  |..:...::|     ||....|....:
  Fly   770 ------------ALMAYSKYFDIITPA--TEAEPIQSLNNMDYYLSIGVKAGAVLLGVILVFIVL 820

  Fly   881 --FNSTLDTTSSSAASKDLKRKKRWNFLSRSKT---PDKQKSATLGREKAT-----TAGQHSKLA 935
              |:                .||..|.|....|   .|....|..||....     |:|.|....
  Fly   821 WVFH----------------HKKTKNELQGEDTLTLRDSLSRALFGRRNHNHSHFITSGNHKGFD 869

  Fly   936 AKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYE 1000
            |.   ....|:|.|.:               |::      .|.:|.....|:|.:|.|......:
  Fly   870 AG---PIHRLDLENAY---------------KNR------HKDTDYGFLREYEMLPNRFSDRTTK 910

  Fly  1001 CALLEENEPKNHDPNFLPYDDNRVRLTPCRD-NRHGYVNASSISATVGTKQR-FYIVAQSPQEPL 1063
            .:.|:||..||..|:...||..||:|..... ....|:||:.:   :|.|:| .:|.||.|.|.
  Fly   911 NSDLKENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFV---IGYKERKKFICAQGPMES- 971

  Fly  1064 TMRIFWQCVWEADVYLVVQLT--EDMS------YIPRNSHQRLEFGQFQVYQEFSQT------TD 1114
            |:..||:.:||..:.::|.||  |:.:      |.|.......:||...|  :|:|.      .:
  Fly   972 TIDDFWRMIWEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILV--KFAQERKTGDYIE 1034

  Fly  1115 RCTTIKLRLYHVPSRR-YRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNT 1178
            |...:.....:|.... .|.:....|..|.:...|...:..:.|:.::|||  .|.|
  Fly  1035 RTLNVSKNKANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSV--YSLQ-------- 1089

  Fly  1179 NPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI 1243
            ..|:|:||..|.||:|..:..|.|:..|:..:.:.|...:..|||||:.::.||.||.|:|..|:
  Fly  1090 RGPILVHCSAGVGRTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALL 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619
		FERM_M	112..230	CDD:459788	22/120 (18%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	25/110 (23%)
		PTP_DSP_cys	1036..1246	CDD:475123	63/223 (28%)
Ptp69D	NP_524048.2	Ig_3	35..114	CDD:464046
		Ig_3	134..216	CDD:464046	20/110 (18%)
		fn3	237..321	CDD:394996	22/89 (25%)
		FN3	<300..>524	CDD:442628	48/279 (17%)
		PTPc	892..1155	CDD:214550	78/278 (28%)
		PTPc	1186..1449	CDD:214550