Protein Alignment Pez and PTP-ER

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_726092.1
• Gene: PTP-ER / 37461
• FlyBaseID: FBgn0016641
• Length: 1377
• Species: Drosophila melanogaster
• Alignment Length: 1374
• Identity: 247/1374 - (17%)
• Similarity: 399/1374 - (29%)
• Gaps: 543/1374 - (39%)

  Fly   270 IDKRTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHK----FFKRYIDTA--------- 321
            |||      :|.:..|||     :..:.:.:.|   |:.|:|.    .||....|.
  Fly   147 IDK------ENTMPKGGS-----VDQDLENSLY---LSKSEHNSPTILFKDESSTTPGLEASRLS 197

  Fly   322 -TPSSLGS--GADAESGPLG-VDSVGY----------VDYDYNEA----AAAEQLQQHHQQQQHM 368
             :|..|.|  ..:....||. ::|.||          :|:...:|    ...|:..:..:.....
  Fly   198 YSPKLLSSINNLNVSGSPLNIINSAGYKNGNFFRFPEIDHVVQDAPMDTVCLEEATRRDRSPALA 262

  Fly   369 QQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDERERL- 432
            :..:|.||:.                                      .|..|..|.|:...|:
  Fly   263 EPPEQQQQKS--------------------------------------EGRKNRKNKNNLTIRIT 289

  Fly   433 -----KAMLPTYRPAPDYETAVQLKYRTPSAE-----------FHNVALAMAAPGNAYYAGSQPD 481
                 .:..|:..|.|...|....|.:..|.:           .||:..:..:..:.....|||.
  Fly   290 DVPIKNSSQPSPLPKPKTPTIKSTKEKARSLDSAANESELSIVVHNITESHGSCDDMETGQSQPS 354

  Fly   482 VHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQS--HPQPMSPAQAYLELSQR 544
                                       .:.:|||::|    .||.|  |...:|...::|.|:.:
  Fly   355 ---------------------------TSVIHHHLHL----QQPASAIHSTSLSRLDSHLSLANQ 388

  Fly   545 MHMMRHKAP---------------PPYVNRLSSSSTPDLAV---ATPRPLQGFRNYVSGSSPDLV 591
            ....|.|:|               |..|.....|||...::   |:..|..|.....|..|   |
  Fly   389 RRTPRRKSPGINTTDWLMYHRKQNPYQVQPTHCSSTTQSSLDSDASLTPSLGDFELKSACS---V 450

  Fly   592 SNRTLFNGGQYVALPAGGHAGNIPTSSGATMLHQ-------YQYVSHMGHSQPYLPPHGTFENLN 649
            ...:.|..|..:| |...|..|....|.:|.|..       .::.|..|.     |....|:..:
  Fly   451 DGGSKFGIGASLA-PRSAHKHNQLLHSSSTNLKTLPECLTLVEFSSSGGG-----PKESPFKQKS 509

  Fly   650 MIEEQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSHKSA 714
            |....|::.::...|..|.......||   ..|.||   ...||.....:|.|       ||.:.
  Fly   510 MDLPMPTLQAKTTVSTSSMNLLQRRGS---NHSLTL---NLHSSCGNLMNSGL-------SHSNY 561

  Fly   715 TPAPLQRS-----LVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASS-------------- 760
            :...:..|     |..|:...|..: .|||....|||..:.....|:|.|:
  Fly   562 SLGSILNSKSSCNLDAGTASQIRAD-QLPQSHLLGSSQGSRQGLFRRRGSNHSITLKTGHTTTSC 625

  Fly   761 --IQSAPGVVPVPAARNASSNNVVTVTVNS------------PPDDGNIKKYGADR--------- 802
              :.|...:....|..:|...|.:.:..||            .|..|.:::.|:::
  Fly   626 GDLNSMQQLQQQQAMLSAEKYNRLNMRTNSTGSGSGSGSNVPTPKRGLLERRGSNQSLTLNMGSI 690

  Fly   803 ---AASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQF 864
               ||.||:...:...||.|..:.:||   ...|..|:..||.:||.|.          ...|:|
  Fly   691 LGGAAGTEIQMTDIVQPKVTVCSCAAA---NQAPHQRKFFSTENLNSSK----------ANSQKF 742

  Fly   865 -------SAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQKSATLGR 922
                   ||.:|..|.. ..|...:..:..|.:.|.:..       |.::|..:|.
  Fly   743 FGQVCFGSASDLQPNPQ-QDSVREDQAIGATCTCAGTVR-------NIMTRPLSPQ--------- 790

  Fly   923 EKATTAGQHSKLAAKLKLAQDDLNLPNRW---------------STGVNKPQPISGRYSKD--KL 970
               ||:.:.....|.:::.|...|..|::               :..:.:..|:.|..::|  ..
  Fly   791 ---TTSEEFKIYLASIQMLQSASNPLNQFDLIRLNYVFDHSYQTNRNIIEQPPVLGSNARDVETP 852

  Fly   971 CQILDQKLSDSQLFMEFERIPKRREHALYECALLEENE---------------PKNHD------- 1013
            ..::.....||:|...::.:..|....:.|   |:|||               |.||.
  Fly   853 TDMVPPSSEDSELLASYQTVVSRMAQPIPE---LKENEQKRIFRDLHKEFWDLPLNHQEKPMVFG 914

  Fly  1014 -------PNFLPYDDNRVRL--------------------TPCRDNRHGYVNASSISATVGTKQR 1051
                   ...||.:::||.|                    |...|  ..|:||:.|... ....:
  Fly   915 SQTKNRYKTILPNENSRVLLESESSELTSLLGEIKRTSSVTASED--LPYINANYIKGP-DYVSK 976

  Fly  1052 FYIVAQSPQEPLTMRIFW------------QCV-----------------------------WEA 1075
            .|:..|.|. |.|:..||            :||                             .||
  Fly   977 CYVATQGPL-PNTIFEFWLMIYQNTQRYIRRCVDGGSSSSPHVDREQILQQYFQKIVMLTNFTEA 1040

  Fly  1076 D-----VYLVVQLTE-----------DMSYIPRNSHQRLEFGQF----------QVYQEFSQTTD 1114
            :     ||..::|.|           .:|...|:...|.....|          .:..|.|....
  Fly  1041 NRQKCAVYFPIELNEIFAVAAKCEVFQLSAAARDYFDRYLTPTFVPDTVVASSDAIDYEISGRHI 1105

  Fly  1115 RCTTIKLRL----------------------------------------------YHVPSRRYRS 1133
            ...::|:.|                                              ||:.......
  Fly  1106 GVESVKVTLEGDLLEALPAQGSFFLIKNVGIVRRNGYSVRKLVLLYCIRVPQSASYHLQKIYCYH 1170

  Fly  1134 VWYLQYADWAEQNCPRDVNHFLD-FLEELNSVRLAS-------TQEVPPGH-------------- 1176
            .|   |.||.:.:.|||:|..|| .|..||..:..|       |:.....|
  Fly  1171 YW---YPDWPDHHSPRDINTLLDTCLHVLNLGKCESEFDIYDDTRSERNAHLAAQRLEIYQQDIF 1232

  Fly  1177 NTNPPV-LLHCLEGGGRSGV---------------------TLTADL------------------ 1201
            |...|: ::||..|.||:|.                     .||..|
  Fly  1233 NAVQPLPVIHCSAGIGRTGCFTAILNAVRQLRQSLAYSLTGMLTKSLTSSSTEEYHNPTDSDSSF 1297

  Fly  1202 -------LLYTLDHNED-------------------LDIPRVIGQLRHQRDSIIPSLAQYKFIYN 1240
                   :.:.|||.:.                   :|:..::..||.||..::.:..||:.|:.
  Fly  1298 TCNTIRHISHILDHRDAEAVKTPPSFDRLPKMPDIFVDVLGIVCNLRLQRGGMVQNSEQYELIHR 1362

  Fly  1241 LLITYLKRT 1249
            .:..|||||
  Fly  1363 AICLYLKRT 1371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619
		FERM_M	112..230	CDD:459788
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	13/50 (26%)
		PTP_DSP_cys	1036..1246	CDD:475123	67/410 (16%)
PTP-ER	NP_726092.1	PTP_DSP_cys	919..1362	CDD:475123	74/449 (16%)