Protein Alignment Pez and Ptpn14

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_001388293.1
• Gene: Ptpn14 / 305064
• RGDID: 1307885
• Length: 1189
• Species: Rattus norvegicus
• Alignment Length: 1387
• Identity: 369/1387 - (26%)
• Similarity: 586/1387 - (42%)
• Gaps: 333/1387 - (24%)

  Fly     1 MP--LKFLKKCRQYNVTSKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFF 63
            ||  || |::.|:|||.||:.||..: .||| |:.::||:|.||.|||||:.|.|||.:::..:|
  Rat     1 MPFGLK-LRRTRRYNVLSKNCFVTRI-RLLD-SNVIECTLSVESTGQECLEAVAQRLELRETHYF 62

  Fly    64 GLRYLVKGKDKEDEFKWIDLERSLSRQLEKYAAGPKIYLRVRHYVTTGVRHLSDEATRFYYFLQL 128
            ||.:|    .|..:.:|::||:.|.:.|:|:|..|.::..|..||.: |..|..||||:.|:||:
  Rat    63 GLWFL----SKSQQARWVELEKPLKKHLDKFANEPLLFFGVMFYVPS-VSRLQQEATRYQYYLQV 122

  Fly   129 KSDIYEGRIACDIRTAILLALYCRQAEYDSY-QGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGL 192
            |.|:.|||:.|.:...|.||....||::..| |.|  |:::|::.::.|.:   ||.:::.||.|
  Rat   123 KKDVLEGRLRCSLEQVIRLAGLAVQADFGDYNQFD--SQEFLREYVLFPMD---LAMEEAALEEL 182

  Fly   193 IVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNADNGR 257
            ..:|.|:....:.:..::||.|||...::|:|:|:|.|..||:.||.:.||:...|:.|....||
  Rat   183 TQKVAQEHKAHSGILPAEAELMYINEVERLDGFGQEIFPVKDSHGNSMHLGIFFMGIFVRNRIGR 247

  Fly   258 Q--YFPWKEFHTVTIDKRTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFK----- 315
            |  .:.|.:..|||..|..|.:|  .:|...:.:  |...:.:.|:|..:|..::|||:|
  Rat   248 QAVIYRWNDIGTVTHSKAAILLE--LIDKEETAL--FHTDDIENAKYISRLFTTRHKFYKQNKIC 308

  Fly   316 ----------RYIDTATPSSLGSGADAESGPLGVDSVGYVDYDYNEAAAAEQLQQHHQQQQHMQQ 370
                      |...|.:.|||.........|:.|                 |..:|:.:....|.
  Rat   309 TEQSNSPPPIRRQPTWSRSSLPRQQPYILPPMHV-----------------QCSEHYSETHTSQD 356

  Fly   371 QQQIQQQQMISSNISLATSANQMLG---QSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDERERL 432
            ......::.:..|...:...|.:.|   ..|.|...|.|:|..|...:.....::|.:....:.:
  Rat   357 SIFPGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSINSLSCSQSFIQASPVSSNLSIPGSDIM 421

  Fly   433 KA-----------MLPTYRPAPDYETAV-QLKYRTPSAEFHNVALAMAAPGNAYYAGSQPDVHNP 485
            :|           ::|:|||.|||||.: |:|.....|:..:.:|......|. :|.:||
  Rat   422 RADYIPSHRHSTIIVPSYRPTPDYETVMRQMKRGLLHADSQSRSLRNLNIINT-HAYNQP----- 480

  Fly   486 GMHNENLLYGH---MTAHRYPDVAQPAAALHHHINLYQAQHQPQSHPQPMSP------------- 534
                |.|:|..   ...|.|.....|.....|.:.....|..||:...|..|
  Rat   481 ----EELVYSQPEMRERHPYTVPYAPQGGYGHKLVSPSDQVNPQNSAMPSKPGAGSISHTVSTPE 541

  Fly   535 -AQAYLELSQR---MHMMRH---KAPPPYVNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDLV- 591
             |...|:.:|.   .||:::   :.||||.....::||||||       .....||||||||||
  Rat   542 LANMQLQGAQHYSTAHMLKNYLFRPPPPYPRPRPATSTPDLA-------SHRHKYVSGSSPDLVT 599

  Fly   592 -------------SNRTLFNGGQYVALPA------GGHAG------------------------- 612
                         |:..:....|.|:.|.      ||..|
  Rat   600 RKVQLSVKTFQEDSSPVVHQSLQEVSEPLTATKHHGGGGGAVNKRHSLEVMNSMVRGMEAMTLKS 664

  Fly   613 -NIPTSSGATMLHQYQYVSHMGHSQPYLPPH---GTFENLNMI--------EEQ--------PSI 657
             |||.:...|:..|.......||....||.:   .||.:..|:        ||:        |.:
  Rat   665 LNIPMARRNTLREQGPSEEAGGHDVHGLPQYHHKKTFSDATMLIHSSESEEEEEAPEAAPQIPEL 729

  Fly   658 MSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSHKSATPAPLQRS 722
            ..::..||..|||.|..        |:.||..|                         |.| ::|
  Rat   730 REKVEYSAQLQAALARI--------PSRPPPEY-------------------------PGP-RKS 760

  Fly   723 LVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPG-VVPVPAARNASSNNVVTVTV 786
            :.||::.. .:...||..|               ||..::..|. .:.|..|...:.|.......
  Rat   761 VSNGTLRQ-DQGTLLPAMA---------------RARVLRHGPAKALSVSRAEQLAVNGASLGPS 809

  Fly   787 NSPPDDGNIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVD 851
            .|.||..::|          |.:..||                              :.:....:
  Rat   810 ISEPDLTSVK----------ERVKKEP------------------------------VKERPVSE 834

  Fly   852 MITPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQK 916
            |.:.....::::....||                             .|::...|...|.| ...
  Rat   835 MFSLEDSIIEREMMIRNL-----------------------------EKQKMTGLQAQKRP-LML 869

  Fly   917 SATLGREKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQKLSDS 981
            :|..|...|..:|:..        .:.|:.                 |...|:..:.|.:||.|.
  Rat   870 AALNGLSVARVSGRED--------GRHDVT-----------------RVPMDERLRALKKKLEDG 909

  Fly   982 QLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATV 1046
            .:|.|:|:||.::.:.::..|.|.||..::.....:||::|||.|.|.::|..||:|||.|...|
  Rat   910 MVFTEYEQIPNKKANGIFSTATLPENAERSRIREVVPYEENRVELIPTKENNTGYINASHIKVVV 974

  Fly  1047 GTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPR--NSHQRLEFG 1101
            |..:..||..|.|. |.|...|||.|||..|.::..:|.:..        |.|:  :.|....:|
  Rat   975 GGSEWHYIATQGPL-PHTCHDFWQMVWEQGVNVIAMVTAEEEGGRTKSHRYWPKLGSKHSSATYG 1038

  Fly  1102 QFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRL 1166
            :|:|..:|...:....|..|::.|:.|.:.|:||:|||.||....||.||..||.:|||:.|||
  Rat  1039 KFKVTTKFRTDSGCYATTGLKVKHLLSGQERTVWHLQYTDWPHHGCPEDVQGFLSYLEEIQSVR- 1102

  Fly  1167 ASTQEVPPGHNT-NPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIP 1230
            ..|..|..|..| :||:::||..|.||:||.:.::|::|.|:|||.:::|.::..||.||..:|.
  Rat  1103 RHTNSVLEGVKTRHPPIVVHCSAGVGRTGVVILSELMIYCLEHNEKVEVPTMLRFLREQRMFMIQ 1167

  Fly  1231 SLAQYKFIYNLLITYLKRTRLI 1252
            ::|||||:|.:|:.:|:.:|||
  Rat  1168 TIAQYKFVYQVLVQFLQNSRLI 1189

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619	35/89 (39%)
		FERM_M	112..230	CDD:459788	42/118 (36%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	30/108 (28%)
		PTP_DSP_cys	1036..1246	CDD:475123	84/220 (38%)
Ptpn14	NP_001388293.1	B41	24..220	CDD:214604	76/207 (37%)
		PH-like	215..305	CDD:473070	30/93 (32%)
		PTPc-N14	898..1184	CDD:350447	106/287 (37%)