Protein Alignment Pez and ZK616.65

DIOPT Version :10

• Sequence 1: NP_609013.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: NP_001293838.1
• Gene: ZK616.65 / 24105295
• WormBaseID: WBGene00235383
• Length: 543
• Species: Caenorhabditis elegans
• Alignment Length: 612
• Identity: 135/612 - (22%)
• Similarity: 237/612 - (38%)
• Gaps: 121/612 - (19%)

  Fly   656 SIMSQLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVPPPASSPLPPPVVASSHKSATPAPLQ 720
            ::.::..:..:::...|:.||..::|.....|:..|..|....|.      ..||||:..
 Worm     2 NMFNRKAKQEVTKKPEASNGSKNSKSKTKFSPNQKRREVKKSDSD------TESSHKNTR----- 55

  Fly   721 RSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVVPVPAARNASSNNVVTVT 785
                        ...|:|...|..|.|:.:....:.....::.....:|...::..:|
 Worm    56 ------------RGKPVPAPPSSNSKGSNDKNKRKSVQEVVKKVVNHIPFSPSKQPTS------- 101

  Fly   786 VNSPP-DDGNIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSST 849
              :|| .:||.|:             |:.:..:|:|:..|..........|.:.|:| ..|.|::
 Worm   102 --TPPVSEGNRKR-------------LQTKVVERSNQIESEMDSFVKKIEPNERRAT-QYNHSNS 150

  Fly   850 V---DMITPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKT 911
            :   :...|.|:..:....|    .:...:|.|:..  ||..:.:..||            .|||
 Worm   151 LSGSNEAVPPGNVKRSPQKA----THPIRTTRSLIG--LDGETEAVYSK------------TSKT 197

  Fly   912 -PDKQK-SATLGREKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQ-- 972
             |||.| :|...|.:.|:    ..|......|.|.::|.:...|          |.:..||.:
 Worm   198 SPDKGKVTADSPRSRRTS----KSLEENSSEANDSISLADDEET----------REAYRKLFKDF 248

  Fly   973 -ILDQKLSDSQLFMEFERIPKRREHALYECALLEE--NEPKNHDPNFLPYDDNRVRLTPC-RDNR 1033
             :..||::......||..:|......|  |....:  |..||...|....|.:||:|... ..|.
 Worm   249 AMSSQKMTLDDFKQEFSNLPGDPPSDL--CTAFNQPVNNKKNRYLNIPCLDISRVQLKVMPNKNS 311

  Fly  1034 HGYVNASSISATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEAD---VYLVVQLTED-----MSYI 1090
            ..|::|:.|.:..  .:|.||:.|.|::. |...||:.:|:.:   :.::.|.||.     ..|.
 Worm   312 TDYIHANYIRSPF--LKRGYILTQGPKKE-TRADFWRMIWQENTTAIVMLCQFTETNREKCAEYF 373

  Fly  1091 PRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFL 1155
            |||:|..|:|.:..|..|.|.......|.:|.|.:....|..:.|.  :.:|.:...|......|
 Worm   374 PRNAHCCLQFDKMSVSYEDSTVNKSLVTTRLNLSYEGETRLITHWL--WKEWPDWQVPGSSEVML 436

  Fly  1156 DFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDL-DIPRVIG 1219
            ..|.:   :|..||          ||| :||..|.||||..:..::.|.::..:..| ||.:::.
 Worm   437 KILRK---IRARST----------PPV-IHCSAGVGRSGTLMAVEIALQSIHSHFTLPDIKQIVS 487

  Fly  1220 QLR-HQRDSIIPSLAQYKFIYNLLITY 1245
            .|| ..|.:.:.:|.||..|:.:|:.:
 Worm   488 HLRVTGRAASVQTLQQYMLIWKVLLDF 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_609013.1	FERM_F1_PTPN14_like	17..107	CDD:340619
		FERM_M	112..230	CDD:459788
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		PTP_DSP_cys	1036..1246	CDD:475123	59/220 (27%)
ZK616.65	NP_001293838.1	PTZ00108	<9..236	CDD:240271	56/294 (19%)
		PTPc	260..513	CDD:214550	73/273 (27%)