DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pez and Ptpn21

DIOPT Version :9

Sequence 1:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_001139671.1	Gene:	Ptpn21 / 24000	MGIID:	1344406	Length:	1176	Species:	Mus musculus

Alignment Length:	1374	Identity:	383/1374 - (27%)
Similarity:	605/1374 - (44%)	Gaps:	320/1374 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLKF---LKKCRQYNVTSKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEF 62
            |||.|   ||:.|:|.|:|||..|..:..|  .:..|:.|:|.||.|||.|:.|.|||.:::..:
Mouse     1 MPLPFGLKLKRTRRYTVSSKSCLVARIQLL--NNEFVEFTLSVESTGQESLEAVAQRLELREVTY 63

  Fly    63 FGLRYLVKGKDKEDEFKWIDLERSLSRQLEKYAAGPKIYLRVRHYVTTGVRHLSDEATRFYYFLQ 127
            |.|.|.    :|:::.:|:|||:.|.:||:|:|..|.:|..|..||.: |..|..|.||:.|:||
Mouse    64 FSLWYY----NKQNQRRWVDLEKPLKKQLDKHALEPTVYFGVLFYVPS-VSQLQQEITRYQYYLQ 123

  Fly   128 LKSDIYEGRIACDIRTAILLALYCRQA---EYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSML 189
            ||.||.||.:.|.:..||.||....||   ::|.|    :|:|:|:|..:||   .....|:.:|
Mouse   124 LKKDILEGNLPCTLEHAIQLAGLAVQADFGDFDQY----ESQDFLQKFALLP---VAWLQDEKVL 181

  Fly   190 EGLIVEVLQQQAGIAH-----LSQSQAEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGM 249
            |    |..|:.| :.|     |:..:||.:|:|..::::|||||.:.|||:.|:|:.:|..::|:
Mouse   182 E----EAAQKVA-LLHQKYRGLTAPEAELLYMQEVERMDGYGEESYPAKDSQGSDISIGACLDGI 241

  Fly   250 VVNADNGRQ--YFPWKEFHTVTIDKRTIKIE-QNKLDGGGSIVGSFIFSEADTARYFWKLTISQH 311
            .|...|||.  .|.|.:...::.:|....:| .||.:     ...|...:.:||:|.|:|.:::|
Mouse   242 FVKHKNGRPPVVFRWHDIANMSHNKSFFALELANKEE-----TIQFQTEDMETAKYVWRLCVARH 301

  Fly   312 KFFK-----RYIDTATPSSLGSGADAESG-----PLGVDSVGYVDYD--YNEAAAAEQLQQHHQQ 364
            ||::     .....||.:|:..|:.:...     |..:.....:.|:  |.|..|:.|
Mouse   302 KFYRLNQCSLQTQAATLNSVRRGSSSRMSLPKPQPYAMPPPPQLHYNGHYTEPFASSQ------- 359

  Fly   365 QQHMQQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGG-----SNNNN 424
                             .|| ...:.|.....|.:.||.:..:|   ||.:.:|.     |.|:.
Mouse   360 -----------------DNI-FVPNKNGFYCHSQTSLDRTQIDL---SGRIRNGSVYSAHSTNSL 403

  Fly   425 NNDE--------------------------RERLKAML-PTYRPAPDYETAV-QLKYRTPSAEFH 461
            |..:                          ..|..|:: |:|||.|||||.: ||......|:.|
Mouse   404 NTLQPYLQPSPMSSNPSITGSDVMRPDYIPSHRHSALIPPSYRPTPDYETVMKQLNRGMVHADRH 468

  Fly   462 NVALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQ 526
            :.:|.....|:: ||.|:||.         |:|.......:|.:..|.:| |:..||..:.|...
Mouse   469 SHSLRNLNIGSS-YAYSRPDA---------LVYSQPEIREHPHLTSPQSA-HYPFNLNYSFHSQS 522

  Fly   527 SHPQPMS----------PAQAYLELSQR-------MHMMRHKAPPPYVNRLSSSSTPDLAVATPR 574
            .:|.|..          |....::|..:       |....::.||||.....::|||||:    |
Mouse   523 PYPYPAERRPVVGAVSVPELTNVQLQAQDYPAPNIMRTQVYRPPPPYPYPRPANSTPDLS----R 583

  Fly   575 PLQGFRNYVSGSSPDLVSNRTLFNGGQYVALPAGGHAGNIPTSSGATMLHQYQYVSHMGHSQPYL 639
            .|     |:|.|:|||::.|.             .|:..........:.|..|.|     |:|..
Mouse   584 HL-----YISSSNPDLITRRV-------------HHSVQTFQEDSLPVAHSLQEV-----SEPLT 625

  Fly   640 PP-HGTFENLNMIEEQPSIMS--------QLRQSAMSQAAAAAAGSVVTQSSPTLPPSGYRSSVP 695
            .. |...:..|.||    |..        :|::..:|.:||..|
Mouse   626 AARHAHLQKRNSIE----IAGLTHGFEGLRLKERTVSASAADVA--------------------- 665

  Fly   696 PPASSPLPPPVVASSHKSATPAPLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASS 760
                                                      |:..|.||..:..::.|:|..:.
Mouse   666 ------------------------------------------PRTFSAGSQSSVFSDKMKQEGTE 688

  Fly   761 IQSAPGVVPVPAARNASSNNV--VTVTVNSPPDDGNIKKYGADRAASTELLFLEPQAPKRTNR-- 821
            .|.        ..|.:...::  .|:.::|..:|.::::..:...|.:.:  .||:.....::
Mouse   689 EQE--------GGRYSHKKSLSDATMLIHSSEEDEDLEEDSSREQAISAV--SEPRLTAAFSQEL 743

  Fly   822 ---AASAAPDMG----------ATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMNLSANT 873
               .|||.|..|          .|.|.::.:..:.::  ..|:...|..|.|
Mouse   744 NYPCASATPITGPLHIFEPKPHVTEPEKRAKDISPVH--LVVETHRPRRDGL------------- 793

  Fly   874 SASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQKSATLGREKATTAGQHS----KL 934
              .|.||..|.|.|:....|.:|..:|:..:.|...|....:....||..|.|.|....    ||
Mouse   794 --LTPSMSESDLTTSGRYRARRDSVKKRPVSDLLSGKKSAVEGLPPLGGMKKTRADAKKIGPLKL 856

  Fly   935 AAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALY 999
            ||...|:...|.||       ::.:.:|.|.:.|:.|::|:|:|....:|.|:|||.|:|   |.
Mouse   857 AALNGLSLSRLPLP-------DEGKEVSTRATNDERCKVLEQRLEQGMVFTEYERILKKR---LV 911

  Fly  1000 --EC--ALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSISATVGTKQRFYIVAQSPQ 1060
              ||  |.|.||..:|...:.|||||.||.|.|.::|..||:|||.|..:|...:..||..|.|.
Mouse   912 DGECSTARLPENAERNRFQDVLPYDDARVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPL 976

  Fly  1061 EPLTMRIFWQCVWEADVYLVVQLT--------EDMSYIPR--NSHQRLEFGQFQVYQEFSQTTDR 1115
            :. |.:.|||.|||..|.::..:|        :...|.||  :.|..:.:|:|::...|...:..
Mouse   977 QN-TCQDFWQMVWEQGVAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGC 1040

  Fly  1116 CTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVR--LASTQEVPPGHNT 1178
            ..|..|::.|:.:.:.|:||:|||.||.|..||.|:..||.:|||:.|||  ..||.| |..|
Mouse  1041 YATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSE-PKSH-- 1102

  Fly  1179 NPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI 1243
            |||:|:||..|.||:||.:.:::::..|:|||.||||||:..||.||..::.:|.||.|:|.:||
Mouse  1103 NPPLLVHCSAGVGRTGVVILSEIMVACLEHNEVLDIPRVLDMLRQQRMMLVQTLGQYTFVYRVLI 1167

  Fly  1244 TYLKRTRLI 1252
            .:||.:|||
Mouse  1168 QFLKSSRLI 1176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_001260127.1	B41	26..230	CDD:214604	78/211 (37%)
		FERM_N	26..93	CDD:286467	25/66 (38%)
		FERM_M	114..230	CDD:278785	45/123 (37%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	30/99 (30%)
		Y_phosphatase	1007..1243	CDD:278528	97/247 (39%)
		PTPc	1009..1243	CDD:238006	96/245 (39%)
Ptpn21	NP_001139671.1	B41	24..222	CDD:214604	79/216 (37%)
		FERM_N	27..90	CDD:286467	25/68 (37%)
		FERM_M	109..220	CDD:278785	43/122 (35%)
		FERM_C_PTPN14_PTPN21	217..307	CDD:270009	30/94 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	668..703		7/42 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	789..825		11/50 (22%)
		PTPc	898..1168	CDD:214550	111/276 (40%)
		PTPc	925..1168	CDD:238006	97/246 (39%)
		Substrate binding. /evidence=ECO:0000250	1110..1116		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3370
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	448	1.000	Inparanoid score	I1606
Isobase	1	0.950	-	0	Normalized mean entropy	S4654
OMA	1	1.010	-	-		QHG47166
OrthoDB	1	1.010	-	-		D144506at2759
OrthoFinder	1	1.000	-	-		FOG0004427
OrthoInspector	1	1.000	-	-		otm44243
orthoMCL	1	0.900	-	-		OOG6_105256
Panther	1	1.100	-	-	O	PTHR45706
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5301
SonicParanoid	1	1.000	-	-		X3138
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.910