DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pez and Ptpn4

DIOPT Version :9

Sequence 1:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_064317.2	Gene:	Ptpn4 / 19258	MGIID:	1099792	Length:	926	Species:	Mus musculus

Alignment Length:	1279	Identity:	259/1279 - (20%)
Similarity:	428/1279 - (33%)	Gaps:	425/1279 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RQYNVTSKSLFVISVH-----HLLDTSSTVDC-TISSESKGQECLDNVCQRLLIQQPEFFGLRYL 68
            |.|||.:..|.....|     ::|...:||.. .::...:||..||.|.:.|.:.:.::|||:.
Mouse    11 RTYNVRASELARDRQHTEVVCNILLLDNTVQAFRVNKHDQGQVLLDIVFKHLDLTERDYFGLQL- 74

  Fly    69 VKGKDKEDEFKWIDLERSLSRQLEKYAAGP-KIYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDI 132
              ..|..|..:|:|..:.:.:||::  ..| .:..||:.:| :....|.:|.||:.||||:|.||
Mouse    75 --ADDSTDNPRWLDPNKPIRKQLKR--GSPYNLNFRVKFFV-SDPNKLQEEYTRYQYFLQIKQDI 134

  Fly   133 YEGRIACDIRTAILLALYCRQAEYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVL 197
            ..||::|...||.|||.:..|:|...|...:....||.....:|...|....:       |.::.
Mouse   135 LTGRLSCPCNTAALLASFAVQSELGDYNQSENLAGYLSDYSFIPNQPQDFEKE-------IAKLH 192

  Fly   198 QQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNADNGR-QYFP 261
            ||..|   ||.::||..|:...:.||.||.|...|:|...|::|:|:...|:::..:..| ..|.
Mouse   193 QQHVG---LSPAEAEFNYLNAARTLELYGVEFHYARDQSNNEILIGVMSGGILIYKNRVRMNTFL 254

  Fly   262 WKEFHTVTIDKRTIKIEQNK-LDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRYIDTATPS- 324
            |.:...::...:...|:..| |......:..|........:..||..:..|.||:  :|...|.
Mouse   255 WLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKTLWKACVEHHTFFR--LDRPLPPQ 317

  Fly   325 --------SLGSGADAESGPLGVDSVGYVDYDYNEAAAAEQLQQHHQQQQHMQQQQQIQQQQMIS 381
                    :||| .....|...|.||.|    ..|.|..:::   ..:.......:::...:::|
Mouse   318 KNFFAHYFTLGS-KFRYCGRTEVQSVQY----GKEKANKDRV---FARSPSKPLARKLMDWEVVS 374

  Fly   382 SNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDERERLKAMLPTYRPAPDYE 446
            .|                  .||::.|.:.|                       ||:..|
Mouse   375 RN------------------SLSDDRLETQS-----------------------LPSRSP----- 393

  Fly   447 TAVQLKYRTPSAEFHNVALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAA 511
                                                  ||..|          ||.....|.|..
Mouse   394 --------------------------------------PGTPN----------HRNSSFTQEATR 410

  Fly   512 LHHHINLYQAQHQPQSHPQPMSPAQAYLELSQRMHMMRHKAPPPYVNRLSSSSTPDLAVATPRPL 576
            :.
Mouse   411 VR--------------------------------------------------------------- 412

  Fly   577 QGFRNYVSGSSPDLVSNRTLFNGGQYVALPAGGHAGNIPTSSGATMLHQYQYVSHMGHSQPYLPP 641
                                                  |:|.|    |...:|.||..|:.::.
Mouse   413 --------------------------------------PSSVG----HLVDHVVHMSPSEDFVS- 434

  Fly   642 HGTFENLNMIEEQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPT--LPPSGYRSSVPPPASSPLPP 704
                      :..||              :..|.|:|.:|||:  .|..|...::||..|.
Mouse   435 ----------QRSPS--------------STQANSIVLESSPSQETPEDGQPPALPPKQSK---- 471

  Fly   705 PVVASSHKSATPAPLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAP-GVV 768
               .:|......:..|:.||..:.|..  :||                     :|..:|.| |.:
Mouse   472 ---KNSWNQIHFSNSQQDLVTHTNESF--DVP---------------------SSPEKSTPNGGI 510

  Fly   769 PVPAARNASSNNVVTVTVNSPPDDG----NIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDM 829
            |        .:|:|.:.: .|.::|    |:|. |.|:           :.|...:|.|...|..
Mouse   511 P--------HDNLVLIKM-KPDENGRFGFNVKG-GYDQ-----------KMPVIVSRVAPGTPAD 554

  Fly   830 GATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMNLSANTSASTSS-------MFNSTLDT 887
            ...|         .||:...|.:|. ..|..:.....:.|....|....|       ..|:..|.
Mouse   555 LCVP---------RLNEGDQVVLIN-GRDIAEHTHDQVVLFIKASCEKHSGELVLLVRPNAVYDV 609

  Fly   888 TSSSAASKDLKRKKRWNFLSRSKTPDKQKSATLGREKATTAGQHSKLAAKLKLAQDDLNLPNRWS 952
            ......|:                ||.|...    |||.....|          |||.:|
Mouse   610 VEEKLESE----------------PDFQYIP----EKAPLDSVH----------QDDHSL----- 639

  Fly   953 TGVNKPQPISGRYSKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFL 1017
                          ::.:.|:.:..::.:.| .:|:::.:::......||.|.:|..||...:..
Mouse   640 --------------RESMIQLAEGLITGTVL-AQFDQLYRKKPGMTMSCAKLPQNISKNRYRDIS 689

  Fly  1018 PYDDNRVRLTPCRDNRHGYVNASSISATVGTKQ--RFYIVAQSPQEPLTMRIFWQCVWEADVYLV 1080
            |||..||.|....|    |:||:.|:..:.:..  ..||..|.|. |.|.:.|||..||....:|
Mouse   690 PYDATRVLLKGNED----YINANYINMEIPSSSIINQYIACQGPL-PHTCKDFWQMTWEQGSSMV 749

  Fly  1081 VQLTEDM--------SYIPRNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYL 1137
            |.||..:        .|.|..| :...:|.:||.....:........|:.|::......|.:..:
Mouse   750 VMLTTQVERGRVKCHQYWPEPS-ESSSYGCYQVTCHSEEGNPAYIFRKMTLFNQEKNESRQLTQI 813

  Fly  1138 QYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLL 1202
            ||..|.:...|.|.:.||||:..:...| |..:|         |:::||..|.||:||.:|.:..
Mouse   814 QYTAWPDHGVPDDSSDFLDFVCHVRDQR-AGKEE---------PIIVHCSAGIGRTGVLITMETA 868

  Fly  1203 LYTLDHNE---DLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLI 1243
            :..::.|:   .|||.|.   :|.||..:|.:.:||:|:...::
Mouse   869 MCLIECNQPVYPLDIVRT---MRDQRAMMIQTPSQYRFVCEAIL 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_001260127.1	B41	26..230	CDD:214604	62/205 (30%)
		FERM_N	26..93	CDD:286467	18/67 (27%)
		FERM_M	114..230	CDD:278785	40/115 (35%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	21/93 (23%)
		Y_phosphatase	1007..1243	CDD:278528	71/248 (29%)
		PTPc	1009..1243	CDD:238006	70/246 (28%)
Ptpn4	NP_064317.2	B41	30..222	CDD:214604	62/207 (30%)
		FERM_N	33..97	CDD:286467	18/66 (27%)
		FERM_M	115..222	CDD:278785	40/116 (34%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	21/95 (22%)
		FA	325..365	CDD:285894	10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	379..412		13/108 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..474		14/76 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..511		7/41 (17%)
		PDZ_signaling	515..602	CDD:238492	20/109 (18%)
		PTPc	657..910	CDD:214550	75/272 (28%)
		PTPc	682..909	CDD:238006	70/245 (29%)
		Substrate binding. /evidence=ECO:0000250	852..858		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900