DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Pez and Ptpn13

DIOPT Version :9

Sequence 1:NP_001260127.1 Gene:Pez / 33882 FlyBaseID:FBgn0031799 Length:1252 Species:Drosophila melanogaster
Sequence 2:NP_035334.2 Gene:Ptpn13 / 19249 MGIID:103293 Length:2451 Species:Mus musculus


Alignment Length:1938 Identity:332/1938 - (17%)
Similarity:561/1938 - (28%) Gaps:804/1938 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 VDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYLVKGKDKEDEFKWIDLERSLSRQL-EKYAAG 97
            ::.|..:::..::..|.|...:.:.:...|.|     ...||:|:.::|.:..|::.. |.:...
Mouse   577 LELTCDTKTICKDVFDMVVAHIGLVEHHLFAL-----ATRKENEYFFVDPDLKLTKVAPEGWKEE 636

  Fly    98 PK----------IYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDIYEGRIACDIRTAILLALYCR 152
            ||          ::.|::.:: ..|..:..:.|...|:|||:.|:.:.|:.||...|:|||....
Mouse   637 PKRKGKAAVDFTLFFRIKFFM-DDVSLIQHDLTCHQYYLQLRKDLLDERVHCDDEAALLLASLAL 700

  Fly   153 QAEYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAH-----LSQSQAE 212
            ||||..||.:.....|.:....||..         ::|.|.|..::::....|     .|:.:.|
Mouse   701 QAEYGDYQPEVHGVSYFRLEHYLPAR---------VMEKLDVSYIKEELPKLHNTYAGASEKETE 756

  Fly   213 EMYIQCCQQLEGYGE--ERFAAKDTLGNDLLLGLAINGMVV-NADNGRQ----YFPWKEFHTVTI 270
            ..:::.||:|..||.  .|...:......:|||:...|::| ...||.:    .|||:|...::.
Mouse   757 LEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRALVLRFPWRETKKISF 821

  Fly   271 DKRTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRY-----------IDTATPS 324
            .|:.|.: ||..||   |..:|....:...:|...|..|||||..:.           |:.|:..
Mouse   822 SKKKITL-QNTSDG---IKHAFQTDSSKACQYLLHLCSSQHKFQLQMRARQSNQDAQDIERASFR 882

  Fly   325 SLGSGADAESG-----------------------PLGV--------------------------- 339
            ||...|::..|                       ||.|                           
Mouse   883 SLNLQAESVRGFNMGRAISTGSLASSTINKLAVRPLSVQAEILKRLSSSEWSLYQPLQNSSKEKT 947

  Fly   340 DSVGY------VDYDYNEAAAAEQLQQHHQQQQHMQQQQQ------------------------- 373
            |...:      :...|::.:.| .|..|.:|..:|:...|                         
Mouse   948 DKASWEEKPRGMSKSYHDLSQA-SLCPHRKQVINMEALPQAFAELVGKPLYPMARSDTESLAGLP 1011

  Fly   374 -IQQQQMISS-------------------------NISLATSANQMLGQSSSCLDLSNNN-LH-- 409
             :...:.::|                         .:||.:|     |:|||.:...:|: ||  
Mouse  1012 KLDNSKSVASLNRSPERRNHESDSSTEDPGQAYVVGMSLPSS-----GKSSSQVPFKDNDTLHKR 1071

  Fly   410 ----------------------------------------------------------------- 409
                                                                             
Mouse  1072 WSIVSSPEREITLVNLKKDPKHGLGFQIIGGEKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLI 1136

  Fly   410 -----SSSGMLHHGGSNNNNNNDERERLKAMLPTYRPAPDYETAVQLKYRTPSAEFHNVALAMAA 469
                 |..|:.||...:...|..|...|....|..:|:           :.||...|      .|
Mouse  1137 SVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPS-----------KVPSTPVH------FA 1184

  Fly   470 PGNAYYAGSQPDVHNPGMH-NENLLYGHMTAHRYPDV-------------------AQPAAALHH 514
            .|...|......:.:..|. :|:..:...|....|:.                   .:.|:....
Mouse  1185 NGMKSYTKKPAYMQDSAMDPSEDQPWPRGTLRHIPESPFGLSGGLREGSLSSQDSRTESASLSQS 1249

  Fly   515 HINLYQAQH-------QPQ-SHPQP-----------------------MSPAQAYLE-------- 540
            .:|.:.|.|       :|| |.|.|                       :|....:|:        
Mouse  1250 QVNGFFASHLGDRGWQEPQHSSPSPSVTTKVNEKTFSDSNRSKAKRRGISDLIEHLDCADSDKDD 1314

  Fly   541 ---LSQRMHMMRHKAPPPYVNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDL-VS-----NRTL 596
               .|.:.|....:.|...::..:.:|.|..:.:.|:|...|...::.:...| :|     |.::
Mouse  1315 STYTSSQDHQTSKQEPSSSLSTSNKTSFPTSSASPPKPGDTFEVELAKTDGSLGISVTGGVNTSV 1379

  Fly   597 FNGGQYV--ALPAGG-------HAG------NIPTSSGATMLHQYQYVSHMGH------------ 634
            .:||.||  .:|.|.       |.|      |..:..|||.....:.:.:.|.            
Mouse  1380 RHGGIYVKAIIPKGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQVP 1444

  Fly   635 -------SQPYLPP----------------------------HGTFE----------------NL 648
                   :.|..||                            ..|||                ..
Mouse  1445 TSRERDPAGPQSPPPDQDAQRQAPEKVAKQTPHVKDYSFVTEDNTFEVKLFKNSSGLGFSFSRED 1509

  Fly   649 NMIEE------------------------------------------QPSIMSQLRQSAMSQAAA 671
            |:|.|                                          |..::|.||.:|...:..
Mouse  1510 NLIPEQINGSIVRVKKLFPGQPAAESGKIDVGDVILKVNGAPLKGLSQQDVISALRGTAPEVSLL 1574

  Fly   672 ---------------------AAAGSVVTQSSPTLPP---------------------------- 687
                                 :.|.|.:..|..|..|                            
Mouse  1575 LCRPAPGVLPEIDTTFLNPLYSPANSFLNSSKETSQPSSSVEQGASSDDNGVSGKTKNHCRAPSR 1639

  Fly   688 ---------SGYRSSVPPPASSPLPPPVVASSHKSATPAPLQRSL---------VNGSIEPIYEN 734
                     ||...||..||..|....|.|..|::  |...:.|:         :.|.:|....:
Mouse  1640 RESYSDHSESGEDDSVRAPAKMPNVTRVAAFPHEA--PRSQEESICAMFYLPRKIPGKLESESSH 1702

  Fly   735 VP----------------LPQRASG---------------------------------------- 743
            .|                .|..|:|                                        
Mouse  1703 PPPLDVSPGQTCQPPAECAPSDATGKHFTHLASQLSKEENITTLKNDLGNHLEDSELEVELLITL 1767

  Fly   744 -----GSSGAANTEAM-------------------RQRASS---------------------IQS 763
                 ||.|...|:..                   |.:|..                     :::
Mouse  1768 VKSEKGSLGFTVTKGSQSIGCYVHDVIQDPAKGDGRLKAGDRLIKVNDTDVTNMTHTDAVNLLRA 1832

  Fly   764 APGVVPVPAAR---------------------------------NASSNNVVTVTVNSPPD---- 791
            ||..|.:...|                                 ..|.:.||.::..:|..    
Mouse  1833 APKTVRLVLGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGGQGSPHGVVYISDINPRSAAAV 1897

  Fly   792 DGNIKKYGA---DRAASTELLFLE----------------------PQAPKRTNRAASAAP---- 827
            ||:::....   ....||:.:.||                      |..|  |.|||.:||    
Mouse  1898 DGSLQLLDIIHYVNGVSTQGMTLEDANRALDLSLPSVVLKVTRDGCPVVP--TTRAAISAPRFTK 1960

  Fly   828 -------DMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMNLSANTSASTS------- 878
                   :....|......|.:.:|.....:.:.|||:....|.........|..|.|       
Mouse  1961 ANGLTSMEPSGQPALMPKNSFSKVNGEGVHEAVCPAGEGSSSQMKESAGLTETKESNSRDDDIYD 2025

  Fly   879 -----SMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTP----------------------DKQK 916
                 .:..|.||.....|  ::|..::.....:.|..|                      |..:
Mouse  2026 DPQEAEVIQSLLDVVDEEA--QNLLNQRHATRRACSPDPLRTNGEAPEEGDTDYDGSPLPEDVPE 2088

  Fly   917 SATLGREKA-----TTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQ----------------- 959
            |.:.|..|.     |.|.|..| ..:....|:..|.....:.|.:..:                 
Mouse  2089 SVSSGEGKVDLASLTAASQEEK-PIEEDATQESRNSTTETTDGEDSSKDPPFLTNEELAALPVVR 2152

  Fly   960 -PISGRYSKDKLCQ-------ILDQKLSDSQLFMEFERIPKRREHALYECAL--LEENEPKNHDP 1014
             |.||:|:..:|..       :|||.:...:|    |.:.:.:  .|.:|.:  .:||..||...
Mouse  2153 VPPSGKYTGTQLQATIRTLQGLLDQGIPSKEL----ENLQELK--PLDQCLIGQTKENRRKNRYK 2211

  Fly  1015 NFLPYDDNRVRLTPCRDNRHGYVNASSISATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYL 1079
            |.||||..||.|    .:..||:|||.|...|||::..||..|.|. |.|:..|||.|||.:..:
Mouse  2212 NILPYDTTRVPL----GDEGGYINASFIRIPVGTQEFVYIACQGPL-PTTVGDFWQMVWEQNSTV 2271

  Fly  1080 VVQLTEDMS--------YIP--------RNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPS 1128
            :..:|:::.        |.|        .|...||...:.|..:.|....       :.|..:.:
Mouse  2272 IAMMTQEVEGEKIKCQRYWPSILGTTTMANERLRLALLRMQQLKGFIVRV-------MALEDIQT 2329

  Fly  1129 RRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRS 1193
            ...|.:.:|.:..|.:.:.|...:..|.|:..:..:|.:.            ||:.||..|.|||
Mouse  2330 GEVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIRRSG------------PVITHCSAGIGRS 2382

  Fly  1194 GVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL 1246
            |..:..|::|..:..:.:.||..::..:|.||..::.:..||.|.|.:::..|
Mouse  2383 GTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVILYVL 2435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PezNP_001260127.1 B41 26..230 CDD:214604 48/213 (23%)
FERM_N 26..93 CDD:286467 10/59 (17%)
FERM_M 114..230 CDD:278785 33/122 (27%)
FERM_C_PTPN14_PTPN21 225..317 CDD:270009 29/98 (30%)
Y_phosphatase 1007..1243 CDD:278528 68/251 (27%)
PTPc 1009..1243 CDD:238006 67/249 (27%)
Ptpn13NP_035334.2 KIND 3..190 CDD:214801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..227
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..457
B41 566..774 CDD:214604 48/211 (23%)
FERM_N 569..631 CDD:286467 10/58 (17%)
FERM_M 661..774 CDD:278785 33/121 (27%)
PH-like 770..870 CDD:302622 28/103 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..966 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1063 8/60 (13%)
PDZ_signaling 1082..1166 CDD:238492 7/83 (8%)
PTN13_u3 1168..1356 CDD:293207 30/204 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1199..1356 22/156 (14%)
PDZ_signaling 1355..1439 CDD:238492 17/83 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1441..1478 3/36 (8%)
PDZ 1488..1578 CDD:214570 11/89 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1602..1662 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1695..1726 3/30 (10%)
PDZ_signaling 1762..1841 CDD:238492 9/78 (12%)
PDZ 1859..1942 CDD:214570 10/82 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2024 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2051..2139 13/88 (15%)
Neuromodulin 2067..2207 CDD:284117 25/146 (17%)
PTPc 2181..2433 CDD:214550 73/281 (26%)
PTPc 2207..2433 CDD:238006 67/249 (27%)
Substrate binding. /evidence=ECO:0000250 2375..2381 2/5 (40%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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