DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pez and Ptpn13

DIOPT Version :10

Sequence 1:NP_609013.1 Gene:Pez / 33882 FlyBaseID:FBgn0031799 Length:1252 Species:Drosophila melanogaster
Sequence 2:NP_035334.2 Gene:Ptpn13 / 19249 MGIID:103293 Length:2451 Species:Mus musculus


Alignment Length:1938 Identity:332/1938 - (17%)
Similarity:561/1938 - (28%) Gaps:804/1938 - (41%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 VDCTISSESKGQECLDNVCQRLLIQQPEFFGLRYLVKGKDKEDEFKWIDLERSLSRQL-EKYAAG 97
            ::.|..:::..::..|.|...:.:.:...|.|     ...||:|:.::|.:..|::.. |.:...
Mouse   577 LELTCDTKTICKDVFDMVVAHIGLVEHHLFAL-----ATRKENEYFFVDPDLKLTKVAPEGWKEE 636

  Fly    98 PK----------IYLRVRHYVTTGVRHLSDEATRFYYFLQLKSDIYEGRIACDIRTAILLALYCR 152
            ||          ::.|::.:: ..|..:..:.|...|:|||:.|:.:.|:.||...|:|||....
Mouse   637 PKRKGKAAVDFTLFFRIKFFM-DDVSLIQHDLTCHQYYLQLRKDLLDERVHCDDEAALLLASLAL 700

  Fly   153 QAEYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSMLEGLIVEVLQQQAGIAH-----LSQSQAE 212
            ||||..||.:.....|.:....||..         ::|.|.|..::::....|     .|:.:.|
Mouse   701 QAEYGDYQPEVHGVSYFRLEHYLPAR---------VMEKLDVSYIKEELPKLHNTYAGASEKETE 756

  Fly   213 EMYIQCCQQLEGYGE--ERFAAKDTLGNDLLLGLAINGMVV-NADNGRQ----YFPWKEFHTVTI 270
            ..:::.||:|..||.  .|...:......:|||:...|::| ...||.:    .|||:|...::.
Mouse   757 LEFLKVCQRLTEYGVHFHRVHPEKKSQTGILLGVCSKGVLVFEVHNGVRALVLRFPWRETKKISF 821

  Fly   271 DKRTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFKRY-----------IDTATPS 324
            .|:.|.: ||..||   |..:|....:...:|...|..|||||..:.           |:.|:..
Mouse   822 SKKKITL-QNTSDG---IKHAFQTDSSKACQYLLHLCSSQHKFQLQMRARQSNQDAQDIERASFR 882

  Fly   325 SLGSGADAESG-----------------------PLGV--------------------------- 339
            ||...|::..|                       ||.|                           
Mouse   883 SLNLQAESVRGFNMGRAISTGSLASSTINKLAVRPLSVQAEILKRLSSSEWSLYQPLQNSSKEKT 947

  Fly   340 DSVGY------VDYDYNEAAAAEQLQQHHQQQQHMQQQQQ------------------------- 373
            |...:      :...|::.:.| .|..|.:|..:|:...|                         
Mouse   948 DKASWEEKPRGMSKSYHDLSQA-SLCPHRKQVINMEALPQAFAELVGKPLYPMARSDTESLAGLP 1011

  Fly   374 -IQQQQMISS-------------------------NISLATSANQMLGQSSSCLDLSNNN-LH-- 409
             :...:.::|                         .:||.:|     |:|||.:...:|: ||  
Mouse  1012 KLDNSKSVASLNRSPERRNHESDSSTEDPGQAYVVGMSLPSS-----GKSSSQVPFKDNDTLHKR 1071

  Fly   410 ----------------------------------------------------------------- 409
                                                                             
Mouse  1072 WSIVSSPEREITLVNLKKDPKHGLGFQIIGGEKMGRLDLGVFISAVTPGGPADLDGCLKPGDRLI 1136

  Fly   410 -----SSSGMLHHGGSNNNNNNDERERLKAMLPTYRPAPDYETAVQLKYRTPSAEFHNVALAMAA 469
                 |..|:.||...:...|..|...|....|..:|:           :.||...|      .|
Mouse  1137 SVNSVSLEGVSHHAAVDILQNAPEDVTLVISQPKEKPS-----------KVPSTPVH------FA 1184

  Fly   470 PGNAYYAGSQPDVHNPGMH-NENLLYGHMTAHRYPDV-------------------AQPAAALHH 514
            .|...|......:.:..|. :|:..:...|....|:.                   .:.|:....
Mouse  1185 NGMKSYTKKPAYMQDSAMDPSEDQPWPRGTLRHIPESPFGLSGGLREGSLSSQDSRTESASLSQS 1249

  Fly   515 HINLYQAQH-------QPQ-SHPQP-----------------------MSPAQAYLE-------- 540
            .:|.:.|.|       :|| |.|.|                       :|....:|:        
Mouse  1250 QVNGFFASHLGDRGWQEPQHSSPSPSVTTKVNEKTFSDSNRSKAKRRGISDLIEHLDCADSDKDD 1314

  Fly   541 ---LSQRMHMMRHKAPPPYVNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDL-VS-----NRTL 596
               .|.:.|....:.|...::..:.:|.|..:.:.|:|...|...::.:...| :|     |.::
Mouse  1315 STYTSSQDHQTSKQEPSSSLSTSNKTSFPTSSASPPKPGDTFEVELAKTDGSLGISVTGGVNTSV 1379

  Fly   597 FNGGQYV--ALPAGG-------HAG------NIPTSSGATMLHQYQYVSHMGH------------ 634
            .:||.||  .:|.|.       |.|      |..:..|||.....:.:.:.|.            
Mouse  1380 RHGGIYVKAIIPKGAAESDGRIHKGDRVLAVNGVSLEGATHKQAVETLRNTGQVVHLLLEKGQVP 1444

  Fly   635 -------SQPYLPP----------------------------HGTFE----------------NL 648
                   :.|..||                            ..|||                ..
Mouse  1445 TSRERDPAGPQSPPPDQDAQRQAPEKVAKQTPHVKDYSFVTEDNTFEVKLFKNSSGLGFSFSRED 1509

  Fly   649 NMIEE------------------------------------------QPSIMSQLRQSAMSQAAA 671
            |:|.|                                          |..::|.||.:|...:..
Mouse  1510 NLIPEQINGSIVRVKKLFPGQPAAESGKIDVGDVILKVNGAPLKGLSQQDVISALRGTAPEVSLL 1574

  Fly   672 ---------------------AAAGSVVTQSSPTLPP---------------------------- 687
                                 :.|.|.:..|..|..|                            
Mouse  1575 LCRPAPGVLPEIDTTFLNPLYSPANSFLNSSKETSQPSSSVEQGASSDDNGVSGKTKNHCRAPSR 1639

  Fly   688 ---------SGYRSSVPPPASSPLPPPVVASSHKSATPAPLQRSL---------VNGSIEPIYEN 734
                     ||...||..||..|....|.|..|::  |...:.|:         :.|.:|....:
Mouse  1640 RESYSDHSESGEDDSVRAPAKMPNVTRVAAFPHEA--PRSQEESICAMFYLPRKIPGKLESESSH 1702

  Fly   735 VP----------------LPQRASG---------------------------------------- 743
            .|                .|..|:|                                        
Mouse  1703 PPPLDVSPGQTCQPPAECAPSDATGKHFTHLASQLSKEENITTLKNDLGNHLEDSELEVELLITL 1767

  Fly   744 -----GSSGAANTEAM-------------------RQRASS---------------------IQS 763
                 ||.|...|:..                   |.:|..                     :::
Mouse  1768 VKSEKGSLGFTVTKGSQSIGCYVHDVIQDPAKGDGRLKAGDRLIKVNDTDVTNMTHTDAVNLLRA 1832

  Fly   764 APGVVPVPAAR---------------------------------NASSNNVVTVTVNSPPD---- 791
            ||..|.:...|                                 ..|.:.||.::..:|..    
Mouse  1833 APKTVRLVLGRILELPRMPVFPHLLPDITVTCHGEELGFSLSGGQGSPHGVVYISDINPRSAAAV 1897

  Fly   792 DGNIKKYGA---DRAASTELLFLE----------------------PQAPKRTNRAASAAP---- 827
            ||:::....   ....||:.:.||                      |..|  |.|||.:||    
Mouse  1898 DGSLQLLDIIHYVNGVSTQGMTLEDANRALDLSLPSVVLKVTRDGCPVVP--TTRAAISAPRFTK 1960

  Fly   828 -------DMGATPPPRQHRSTASLNKSSTVDMITPAGDTLQQQFSAMNLSANTSASTS------- 878
                   :....|......|.:.:|.....:.:.|||:....|.........|..|.|       
Mouse  1961 ANGLTSMEPSGQPALMPKNSFSKVNGEGVHEAVCPAGEGSSSQMKESAGLTETKESNSRDDDIYD 2025

  Fly   879 -----SMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTP----------------------DKQK 916
                 .:..|.||.....|  ::|..::.....:.|..|                      |..:
Mouse  2026 DPQEAEVIQSLLDVVDEEA--QNLLNQRHATRRACSPDPLRTNGEAPEEGDTDYDGSPLPEDVPE 2088

  Fly   917 SATLGREKA-----TTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQ----------------- 959
            |.:.|..|.     |.|.|..| ..:....|:..|.....:.|.:..:                 
Mouse  2089 SVSSGEGKVDLASLTAASQEEK-PIEEDATQESRNSTTETTDGEDSSKDPPFLTNEELAALPVVR 2152

  Fly   960 -PISGRYSKDKLCQ-------ILDQKLSDSQLFMEFERIPKRREHALYECAL--LEENEPKNHDP 1014
             |.||:|:..:|..       :|||.:...:|    |.:.:.:  .|.:|.:  .:||..||...
Mouse  2153 VPPSGKYTGTQLQATIRTLQGLLDQGIPSKEL----ENLQELK--PLDQCLIGQTKENRRKNRYK 2211

  Fly  1015 NFLPYDDNRVRLTPCRDNRHGYVNASSISATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYL 1079
            |.||||..||.|    .:..||:|||.|...|||::..||..|.|. |.|:..|||.|||.:..:
Mouse  2212 NILPYDTTRVPL----GDEGGYINASFIRIPVGTQEFVYIACQGPL-PTTVGDFWQMVWEQNSTV 2271

  Fly  1080 VVQLTEDMS--------YIP--------RNSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPS 1128
            :..:|:::.        |.|        .|...||...:.|..:.|....       :.|..:.:
Mouse  2272 IAMMTQEVEGEKIKCQRYWPSILGTTTMANERLRLALLRMQQLKGFIVRV-------MALEDIQT 2329

  Fly  1129 RRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRS 1193
            ...|.:.:|.:..|.:.:.|...:..|.|:..:..:|.:.            ||:.||..|.|||
Mouse  2330 GEVRHISHLNFTAWPDHDTPSQPDDLLTFISYMRHIRRSG------------PVITHCSAGIGRS 2382

  Fly  1194 GVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYL 1246
            |..:..|::|..:..:.:.||..::..:|.||..::.:..||.|.|.:::..|
Mouse  2383 GTLICIDVVLGLISQDLEFDISDLVRCMRLQRHGMVQTEGQYVFCYQVILYVL 2435

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PezNP_609013.1 FERM_F1_PTPN14_like 17..107 CDD:340619 14/83 (17%)
FERM_M 112..230 CDD:459788 34/124 (27%)
FERM_C_PTPN14_PTPN21 225..317 CDD:270009 29/98 (30%)
PTP_DSP_cys 1036..1246 CDD:475123 56/225 (25%)
Ptpn13NP_035334.2 KIND 3..190 CDD:214801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..227
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 253..285
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 429..457
FERM_F1_PTPN13 564..659 CDD:340715 14/87 (16%)
B41 566..774 CDD:214604 48/211 (23%)
PH-like 770..870 CDD:473070 28/103 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 944..966 2/21 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1063 8/60 (13%)
PDZ1_PTPN13-like 1081..1172 CDD:467285 8/90 (9%)
PTN13_u3 1168..1356 CDD:465189 30/204 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1199..1356 22/156 (14%)
PDZ2-PTPN13_FRMPD2-like 1354..1440 CDD:467254 17/85 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1441..1478 3/36 (8%)
PDZ3_PTPN13_FRMPD2-like 1489..1578 CDD:467181 11/88 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1602..1662 9/59 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1695..1726 3/30 (10%)
PDZ4_PTPN13-like 1760..1844 CDD:467182 9/83 (11%)
PDZ5_PTPN13-like 1855..1941 CDD:467183 10/85 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1991..2024 7/32 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2051..2139 13/88 (15%)
PTPc-N13 2202..2435 CDD:350445 69/256 (27%)
Blue background indicates that the domain is not in the aligned region.

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