DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pez and eak-6

DIOPT Version :9

Sequence 1:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_001122449.1	Gene:	eak-6 / 184324	WormBaseID:	WBGene00008663	Length:	405	Species:	Caenorhabditis elegans

Alignment Length:	318	Identity:	85/318 - (26%)
Similarity:	142/318 - (44%)	Gaps:	59/318 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   966 SKDKLCQILDQKLSDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNF---LPYDDNRVRLT 1027
            :|:.:...::|:::   :..:|:|..:.|       .:.|....:|...|.   :|||.|.|.||
Worm    22 NKNHIWNRINQRIN---IIADFDRYQRAR-------TISEGQRTENIHRNIYGAVPYDYNLVNLT 76

  Fly  1028 PCRDNRHGYVNASSIS-ATVGTKQRFYIV---AQSPQEPLTMRIFWQCVWEADVYLVVQLTEDM- 1087
            ..:.|..||:|||... ..:|   |.||:   ||..|.|    .|||.|:|.....:|.|.||:
Worm    77 STQRNPLGYINASVAEFPEIG---RHYIITGAAQDTQIP----FFWQMVFEQKSPAIVMLLEDVE 134

  Fly  1088 -------SYIPRNSHQRLEFGQFQV-YQEFSQTTDRCTTIKLRLYHVP-SRRYRSVWYLQYADWA 1143
                   .|.|.|:.:.|:||.:.: .:||.:.    ..::.||..|. ......|.:.::..|.
Worm   135 LGIEKSDKYFPNNTREELKFGIYDITCKEFVKR----NILEYRLLEVSVGNETHQVHHYKFHGWT 195

  Fly  1144 EQNCPR--DVNHFLDFLEELNSVRLA------------STQEVPPGHNTNPPVLLHCLEGGGRSG 1194
            |.|.|:  |...|.:.::|:....||            .....||   ||.|: :.|..||.|.|
Worm   196 EFNLPKYEDFMAFYNTMKEVGVPLLAVMKNNCMSSFFKKYHHTPP---TNAPI-IQCSTGGARCG 256

  Fly  1195 VTLTADLLLYTLDH--NEDLDIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTR 1250
            |.:..|:|:..:|:  .....|...:.::|.:|:....:..|:.|||:::|.|: |||
Worm   257 VFIIIDILINLIDNRIKNSYSIEWWMLKVRSKRNHSALTNQQHSFIYDIIIKYI-RTR 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_001260127.1	B41	26..230	CDD:214604
		FERM_N	26..93	CDD:286467
		FERM_M	114..230	CDD:278785
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009
		Y_phosphatase	1007..1243	CDD:278528	74/268 (28%)
		PTPc	1009..1243	CDD:238006	74/266 (28%)
eak-6	NP_001122449.1	PTPc	36..308	CDD:214550	78/293 (27%)
eak-6	NP_001122449.1	PTPc	66..307	CDD:238006	72/255 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D144506at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920