DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pez and FRMPD2

DIOPT Version :9

Sequence 1:NP_001260127.1 Gene:Pez / 33882 FlyBaseID:FBgn0031799 Length:1252 Species:Drosophila melanogaster
Sequence 2:NP_001018081.4 Gene:FRMPD2 / 143162 HGNCID:28572 Length:1309 Species:Homo sapiens


Alignment Length:1140 Identity:231/1140 - (20%)
Similarity:392/1140 - (34%) Gaps:352/1140 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 KKCRQYNVTSKSLFVISVH--HL---LDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFFGLR 66
            ||.:.| :..:.|.|:.::  ||   .|..|||....::          |.....:::..:|||.
Human   333 KKGKSY-LALRDLCVVLLNGQHLEVKCDVESTVGAVFNA----------VTSFANLEELTYFGLA 386

  Fly    67 YLVKGKDKEDEFKWIDLERSLSR--------QLEKYAAGP-KIYLRVRHYVTTGVRH---LSDEA 119
            |:     |..||.::|.|..|.:        |.:|.:... .::||::.:|:    |   |....
Human   387 YM-----KSKEFFFLDSETRLCKIAPEGWREQPQKTSMNTFTLFLRIKFFVS----HYGLLQHSL 442

  Fly   120 TRFYYFLQLKSDIYEGRIACDIRTAILLALYCRQAEYDSYQGDK-QSK------DYLKKSLVLPR 177
            ||..::|||:.||.|.|:.|:....:.|.:...|||:.:|..:: :||      ||:..||:  .
Human   443 TRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLI--E 505

  Fly   178 NMQGLANDDSMLEGLIVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYG---EERFAAKDTLGND 239
            .|..|.        :.|||.:.....:.|....||..:::..|||..||   .:.|:.|.....:
Human   506 RMTALR--------VQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEE 562

  Fly   240 LLLGLAINGMVV-----NADNGRQYFPWKEFHTVTIDKRTIKIE--QNKLDGGGSIVG---SFIF 294
            :.||:...|::|     |:......|.|:|         |.||.  |.|.....|:.|   :|:.
Human   563 MALGICAKGVIVYEVKNNSRIAMLRFQWRE---------TGKISTYQKKFTITSSVTGKKHTFVT 618

  Fly   295 SEADTARYFWKLTISQHKFFKRYIDTATPSSLGSGADAESGPLGVDSVGYVDYDYNEAAAAEQLQ 359
            ..|.|::|...|..:||.|         .:.:|||..:           :|.:|:::......|.
Human   619 DSAKTSKYLLDLCSAQHGF---------NAQMGSGQPS-----------HVLFDHDKFVQMANLS 663

  Fly   360 QHHQQQQH---MQQQQQIQQQQMISSNIS------LATSANQM------------LGQS------ 397
            ..||.:..   ..|:....:.::..|.:.      |:||.:..            :|:|      
Human   664 PAHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGRE 728

  Fly   398 ---SSCLDLSNNNLHSSSG---MLHHGGSNNNNNNDERERLKAMLPTYRPAPDYE-TAVQLKYRT 455
               |:|:........|.||   ...|.||.||       |.|:.:    ..|..| ..|.|| |.
Human   729 QLKSACVIQKPMTWDSLSGPPVQSMHAGSKNN-------RRKSFI----AEPGREIVRVTLK-RD 781

  Fly   456 PSAEFHNVALAMAAPGNAYYAGSQPDVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQ 520
            |...|..|.      ....|:| |.|   ||:...:::.|                         
Human   782 PHRGFGFVI------NEGEYSG-QAD---PGIFISSIIPG------------------------- 811

  Fly   521 AQHQPQSHPQPMSPAQAYLELSQ--------RMHMMRHKAPPPYVNRLSSSSTPDLAVATPRPLQ 577
               .|....:.:.|....|.|:.        .|.:...:..|..:..:.|.|            :
Human   812 ---GPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQS------------K 861

  Fly   578 GFRNYVSGSSPDLVSNRTLFNGGQYVALPAGGHAGNIPT-------------SSGATML-----H 624
            |    |.|::||...|.|..:|.....:.:.|:.|::.:             .:|...|     |
Human   862 G----VGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRH 922

  Fly   625 QYQY--VSHMGHSQPYLPPH---GTFENLNMIEEQPSIMSQLRQSAMSQAAAAAAGSVVTQSSPT 684
            |..:  :...|.|.|..||.   |....:.:::|..::                 |..||....|
Human   923 QLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTL-----------------GFSVTGGINT 970

  Fly   685 LPPSG--YRSSVPPPASSPLPPPVVAS--------------SHKSAT-----PAPLQRSLVNGSI 728
            ..|.|  |..|:.|...:.....::..              :||.|.     |..:.|.::...:
Human   971 SVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRV 1035

  Fly   729 EPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVVPVPAARNASSNNVVTVTVNSPPDDG 793
            ....:..|....:.|..         |...|.:.:.||          ..::.|:|| :.|..:.
Human  1036 PRSTQQCPSANDSMGDE---------RTAVSLVTALPG----------RPSSCVSVT-DGPKFEV 1080

  Fly   794 NIKKYG---------ADRAASTEL---------LFLEPQAPKRTNRAASAAPDMGATPPPRQHRS 840
            .:||..         .::.:.:.|         ||  |..|...|.|.:|...:.|.    ..||
Human  1081 KLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLF--PGQPAEENGAIAAGDIILAV----NGRS 1139

  Fly   841 TASLNKSSTVDMI-------------TPAG--DTLQQQFSAMNLSANTSASTSSMFNSTLDTTSS 890
            |..|.....:.::             .|.|  ..|:|::....|||:.        ..|..|.:.
Human  1140 TEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADK--------EFTRATCTD 1196

  Fly   891 SAASKDLKRKKRWNFLSRSKTPDKQKSATLGREKATTAGQHSKLAAKLKLAQDDLNLPNRWSTGV 955
            |..|..|.::..|.   .|.:||..:...|..|.:..|         ::.||...|....|::.:
Human  1197 SCTSPILDQEDSWR---DSASPDAGEGLGLRPESSQKA---------IREAQWGQNRERPWASSL 1249

  Fly   956 -NKPQPISGRYSKDKLCQILDQKLSDSQLFMEFER 989
             :.|:      |...||: |.|:..:|.|....|:
Human  1250 THSPE------SHPHLCK-LHQERDESTLATSLEK 1277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PezNP_001260127.1 B41 26..230 CDD:214604 58/228 (25%)
FERM_N 26..93 CDD:286467 18/77 (23%)
FERM_M 114..230 CDD:278785 36/128 (28%)
FERM_C_PTPN14_PTPN21 225..317 CDD:270009 27/104 (26%)
Y_phosphatase 1007..1243 CDD:278528
PTPc 1009..1243 CDD:238006
FRMPD2NP_001018081.4 KIND 15..197 CDD:214801
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 214..249
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 266..302
B41 346..550 CDD:214604 59/232 (25%)
FERM_C_PTPH13 546..647 CDD:270008 29/118 (25%)
PDZ_signaling 773..857 CDD:238492 20/122 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 859..880 8/36 (22%)
PDZ 947..1034 CDD:214570 15/103 (15%)
PDZ 1078..1167 CDD:214570 15/94 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1204..1228 6/26 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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