DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pez and PTPN21

DIOPT Version :9

Sequence 1:	NP_001260127.1	Gene:	Pez / 33882	FlyBaseID:	FBgn0031799	Length:	1252	Species:	Drosophila melanogaster
Sequence 2:	NP_008970.2	Gene:	PTPN21 / 11099	HGNCID:	9651	Length:	1174	Species:	Homo sapiens

Alignment Length:	1340	Identity:	386/1340 - (28%)
Similarity:	607/1340 - (45%)	Gaps:	254/1340 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPLKF---LKKCRQYNVTSKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEF 62
            |||.|   ||:.|:|.|:|||..|..:..|  .:..|:.|:|.||.|||.|:.|.|||.:::..:
Human     1 MPLPFGLKLKRTRRYTVSSKSCLVARIQLL--NNEFVEFTLSVESTGQESLEAVAQRLELREVTY 63

  Fly    63 FGLRYLVKGKDKEDEFKWIDLERSLSRQLEKYAAGPKIYLRVRHYVTTGVRHLSDEATRFYYFLQ 127
            |.|.|.    :|:::.:|:|||:.|.:||:|||..|.:|..|..||.: |..|..|.||:.|:||
Human    64 FSLWYY----NKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYVPS-VSQLQQEITRYQYYLQ 123

  Fly   128 LKSDIYEGRIACDIRTAILLALYCRQA---EYDSYQGDKQSKDYLKKSLVLPRNMQGLANDDSML 189
            ||.||.||.|.|.:..||.||....||   ::|.|    :|:|:|:|..:.|   .|...|:.:|
Human   124 LKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQY----ESQDFLQKFALFP---VGWLQDEKVL 181

  Fly   190 EGLIVEVLQQQAGIAH-----LSQSQAEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGM 249
            |    |..|:.| :.|     |:...||.:|:|..::::|||||.:.|||:.|:|:.:|..:.|:
Human   182 E----EATQKVA-LLHQKYRGLTAPDAEMLYMQEVERMDGYGEESYPAKDSQGSDISIGACLEGI 241

  Fly   250 VVNADNGRQ--YFPWKEFHTVTIDKRTIKIE-QNKLDGGGSIVGSFIFSEADTARYFWKLTISQH 311
            .|...|||.  .|.|.:...::.:|....:| .||.:     ...|...:.:||:|.|:|.:::|
Human   242 FVKHKNGRHPVVFRWHDIANMSHNKSFFALELANKEE-----TIQFQTEDMETAKYIWRLCVARH 301

  Fly   312 KFFK-----RYIDTATPSSLGSGADAESG-----PLGVDSVGYVDYD--YNE--AAAAEQLQQHH 362
            ||::     ....|.|.:.:...:.:...     |..:.....:.|:  |.|  |::.:.|...:
Human   302 KFYRLNQCNLQTQTVTVNPIRRRSSSRMSLPKPQPYVMPPPPQLHYNGHYTEPYASSQDNLFVPN 366

  Fly   363 QQQQHMQQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGGSNNN---N 424
            |...:...|..:.:.|:         ..|..:...|.....|.|:|::....|.....::|   .
Human   367 QNGYYCHSQTSLDRAQI---------DLNGRIRNGSVYSAHSTNSLNNPQPYLQPSPMSSNPSIT 422

  Fly   425 NND-------ERERLKAML-PTYRPAPDYETAV-QLKYRTPSAEFHNVALAMAAPGNAYYAGSQP 480
            .:|       ...|..|:: |:|||.|||||.: ||......||..:.:|.....|:: ||.|:|
Human   423 GSDVMRPDYLPSHRHSAVIPPSYRPTPDYETVMKQLNRGLVHAERQSHSLRNLNIGSS-YAYSRP 486

  Fly   481 DVHNPGMHNENLLYGHMTAHRYPDVAQPAAALHHHINLYQAQHQPQSHPQP-------------- 531
            ..         |:|.......:..:..|||| |...:|..:.|.|..:|.|
Human   487 AA---------LVYSQPEIREHAQLPSPAAA-HCPFSLSYSFHSPSPYPYPAERRPVVGAVSVPE 541

  Fly   532 MSPAQAYLELSQRMHMMR---HKAPPPYVNRLSSSSTPDLAVATPRPLQGFRNYVSGSSPDLVSN 593
            ::.||...:.....::||   ::.||||.....::|||||:    |.|     |:|.|:|||::.
Human   542 LTNAQLQAQDYPSPNIMRTQVYRPPPPYPPPRPANSTPDLS----RHL-----YISSSNPDLITR 597

  Fly   594 RT-----LFNGGQYVALPAGGHAGNIP---TSSGATMLHQYQYVSHMGHSQPYLPPHGTFENLNM 650
            |.     .|   |..:||.......:.   |::....||:...:...|.|      || .|.|
Human   598 RVHHSVQTF---QEDSLPVAHSLQEVSEPLTAARHAQLHKRNSIEVAGLS------HG-LEGL-- 650

  Fly   651 IEEQPSIMSQLRQSAMSQAAAAAAGSVVT-QSSPTLPPSGYRSSVPPPASSPLPPPVVASSH-KS 713
                     :|::..:|.:||..|...|: .|.|::.....:...|..|..      :...| ||
Human   651 ---------RLKERTLSASAAEVAPRAVSVGSQPSVFTERTQREGPEEAEG------LRYGHKKS 700

  Fly   714 ATPAPLQRSLVNGSIEPIYENVPLPQRASGGSSGAANTEAMRQRASSIQSAPGVVPVPAARNASS 778
            .:.|.:   |::.|.|...|:.   :..||..:..|.....|         ||:
Human   701 LSDATM---LIHSSEEEEDEDF---EEESGARAPPARAREPR---------PGL----------- 739

  Fly   779 NNVVTVTVNSPPDDGNIKKYGADRA-ASTELLFLEPQA--PKRTNRAASAAPDMGATPPPRQHRS 840
                   ...||        |..|. .:..|..|||:|  |....|...::|          .|:
Human   740 -------AQDPP--------GCPRVLLAGPLHILEPKAHVPDAEKRMMDSSP----------VRT 779

  Fly   841 TASLNKSSTVDMITPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNF 905
            ||...:.....::.|                       ||..|.|.|:....|.:|..:|:..:.
Human   780 TAEAQRPWRDGLLMP-----------------------SMSESDLTTSGRYRARRDSLKKRPVSD 821

  Fly   906 LSRSKTPDKQKSATLGREKATTAGQHS----KLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYS 966
            |...|....:....||..|.|......    ||||...|:...:.||       ::.:.::.|.:
Human   822 LLSGKKNIVEGLPPLGGMKKTRVDAKKIGPLKLAALNGLSLSRVPLP-------DEGKEVATRAT 879

  Fly   967 KDKLCQILDQKLSDSQLFMEFERIPKRREHALY--EC--ALLEENEPKNHDPNFLPYDDNRVRLT 1027
            .|:.|:||:|:|....:|.|:|||.|:|   |.  ||  |.|.||..:|...:.|||||.||.|.
Human   880 NDERCKILEQRLEQGMVFTEYERILKKR---LVDGECSTARLPENAERNRFQDVLPYDDVRVELV 941

  Fly  1028 PCRDNRHGYVNASSISATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLT-------- 1084
            |.::|..||:|||.|..:|...:..||..|.|.:. |.:.|||.|||..:.::..:|
Human   942 PTKENNTGYINASHIKVSVSGIEWDYIATQGPLQN-TCQDFWQMVWEQGIAIIAMVTAEEEGGRE 1005

  Fly  1085 EDMSYIPR--NSHQRLEFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNC 1147
            :...|.||  :.|..:.:|:|::...|...:....|..|::.|:.:.:.|:||:|||.||.|..|
Human  1006 KSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGC 1070

  Fly  1148 PRDVNHFLDFLEELNSVRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDL 1212
            |.|:..||.:|||:.|||..:.....| .:.|||:|:||..|.||:||.:.:::::..|:|||.|
Human  1071 PEDLKGFLSYLEEIQSVRRHTNSTSDP-QSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVL 1134

  Fly  1213 DIPRVIGQLRHQRDSIIPSLAQYKFIYNLLITYLKRTRLI 1252
            |||||:..||.||..::.:|.||.|:|.:||.:||.:|||
Human  1135 DIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRLI 1174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_001260127.1	B41	26..230	CDD:214604	80/211 (38%)
		FERM_N	26..93	CDD:286467	25/66 (38%)
		FERM_M	114..230	CDD:278785	46/123 (37%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	30/99 (30%)
		Y_phosphatase	1007..1243	CDD:278528	92/245 (38%)
		PTPc	1009..1243	CDD:238006	91/243 (37%)
PTPN21	NP_008970.2	B41	24..222	CDD:214604	81/216 (38%)
		FERM_N	27..90	CDD:286467	25/68 (37%)
		FERM_M	109..220	CDD:278785	44/122 (36%)
		FERM_C_PTPN14_PTPN21	217..307	CDD:270009	30/94 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..445		9/48 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	673..692		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..745		11/71 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	769..806		11/69 (16%)
		PTPc	896..1166	CDD:214550	106/274 (39%)
		PTPc	923..1166	CDD:238006	92/244 (38%)
		Substrate binding. /evidence=ECO:0000250	1108..1114		2/5 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3388
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	440	1.000	Inparanoid score	I1673
Isobase	1	0.950	-	0	Normalized mean entropy	S4654
OMA	1	1.010	-	-		QHG47166
OrthoDB	1	1.010	-	-		D144506at2759
OrthoFinder	1	1.000	-	-		FOG0004427
OrthoInspector	1	1.000	-	-		otm42192
orthoMCL	1	0.900	-	-		OOG6_105256
Panther	1	1.100	-	-	O	PTHR45706
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5301
SonicParanoid	1	1.000	-	-		X3138
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.950