Protein Alignment Pez and ptpn14

DIOPT Version :9

• Sequence 1: NP_001260127.1
• Gene: Pez / 33882
• FlyBaseID: FBgn0031799
• Length: 1252
• Species: Drosophila melanogaster
• Sequence 2: XP_031758936.1
• Gene: ptpn14 / 100379917
• XenbaseID: XB-GENE-985641
• Length: 1176
• Species: Xenopus tropicalis
• Alignment Length: 1389
• Identity: 360/1389 - (25%)
• Similarity: 572/1389 - (41%)
• Gaps: 350/1389 - (25%)

  Fly     1 MP--LKFLKKCRQYNVTSKSLFVISVHHLLDTSSTVDCTISSESKGQECLDNVCQRLLIQQPEFF 63
            ||  || |::.::|||.||:.||:.: .||| :|.|:.|.:.:|.|.|||:.|.|||.:.:...|
 Frog     1 MPFGLK-LRRTKRYNVLSKNCFVVRI-QLLD-NSEVEYTRTVDSTGLECLEAVAQRLELCEIHCF 62

  Fly    64 GLRYLVKGKDKEDEFKWIDLERSLSRQLEKYAAGPKIYLRVRHYVTTGVRHLSDEATRFYYFLQL 128
            ||:|:    .|.::.:|::||:||.:||:|:|....::..:.:|| ..|.:|....||..|:|||
 Frog    63 GLQYV----GKNNQMRWVELEKSLKKQLDKFANKFLVFFGIMYYV-PNVSYLKQPTTRTQYYLQL 122

  Fly   129 KSDIYEGRIACDIRTAILLALYCRQAEYDSYQ--GDKQSKDYLKKSLVLPRNMQGLANDDSMLEG 191
            |.|:||||:.........||....:||...:.  |   :..:||...:.|   |....|::||||
 Frog   123 KKDVYEGRLCGSAEQYFRLAGLALRAEIKDFDLLG---TYHFLKDYTLFP---QAWTKDEAMLEG 181

  Fly   192 LIVEVLQQQAGIAHLSQSQAEEMYIQCCQQLEGYGEERFAAKDTLGNDLLLGLAINGMVVNADNG 256
            |..:|..:...::.:..::||.:|::..:.::|||:|.|..||..|||:.|.::..|:.:. :|.
 Frog   182 LCHKVALEYKALSGIPSAEAEILYLKEAEHMDGYGQESFHMKDNHGNDINLCISFMGIFIR-NNC 245

  Fly   257 RQ---YFPWKEFHTVTIDKRTIKIEQNKLDGGGSIVGSFIFSEADTARYFWKLTISQHKFFK-RY 317
            ||   .:.|.:...:|.:|..|.:|.|:.:.    |..|...:.:.::|..:|..::|||:| ..
 Frog   246 RQATATYRWSDIGNITHNKSAIVLELNRKEE----VVVFSTDDIENSKYITRLFAARHKFYKDNK 306

  Fly   318 IDTATPSSLGSGADAESGPLGVDSVGYVDYDYNEAAAAEQL----QQH--------------HQQ 364
            |.|          :..|.|..|..    ..::|.::.:.|.    .:|              |..
 Frog   307 ICT----------EQSSSPPAVRR----QPNWNRSSMSRQQTILPPRHIHGGETYISEDNIFHMN 357

  Fly   365 QQHMQQQQQIQQQQMISSNISLATSANQMLGQSSSCLDLSNNNLHSSSGMLHHGGSNNNNNNDER 429
            :.....:.|....:.:..|....|..|   |..||...:  |:|:.|...:.....:::.:....
 Frog   358 EDAFNYRSQTSLDRYLDPNFINGTLVN---GSDSSAHSI--NSLNRSQNFIQASPMSSSLSIQSN 417

  Fly   430 ERLKA-----------MLPTYRPAPDYETAVQLKYR------TPSAEFHNVALAMAAPGN--AYY 475
            :.::|           :.|:|||.|||||.::...|      ..|....|:.:     ||  ||
 Frog   418 DIMRADYIPSYRHSAIIAPSYRPTPDYETVMRQMNRGIIPMDCQSQSLRNLNI-----GNTHAY- 476

  Fly   476 AGSQPDVHNPGMHNENLLYGH---MTAHRY--PDVAQ----------------------PAAALH 513
                       .|.|||:|..   ...|.|  |.|.|                      .|.|:.
 Frog   477 -----------RHRENLVYSQPEIQERHAYVPPYVPQTAYTNVLINPIEQINPTKVTSNQAKAIS 530

  Fly   514 HHINLYQAQHQPQSHPQPMSPAQAYLE--LSQRMHMMRHKAPPPYVNRLSSSSTPDLAVATPRPL 576
            |.::..:..:.|   ||.:..|...|:  ||        :.||||.....:|||||||
 Frog   531 HTVSTPELANVP---PQAVQSAALMLKNFLS--------RPPPPYPPTRPASSTPDLA------- 577

  Fly   577 QGFRNYVSGSSPDLVSNR--------------TLFNGGQYVALPAGGHAGNIPTSSGATMLHQYQ 627
            ...:..|||||||||:.:              .:....|.|:.|    ...:.........|.::
 Frog   578 SHRQKRVSGSSPDLVTRKVQQSVKTFQEDSAPVVHQSLQEVSEP----LMMVKPHPSVNKCHSFE 638

  Fly   628 YVSHMGHS---------QPYLPPHGTFENLNMIEEQPSIMSQLRQSAM-------SQAAAAAAGS 676
            .:::|...         ..:||...|.......||......:::|..|       |.|......|
 Frog   639 VITNMVRGMEAMALKTMNAHLPRRNTLREQVPTEESMQKAHEVQQLPMYHHKKNISDATMLILSS 703

  Fly   677 VVTQS-------SPTLPPSGYRSSVPPPAS----SPLPPPVVASSHKSATPAPLQRSLVNGSIEP 730
            ...:.       |||.|..|...|....|:    ...|||        ..|.| ::|:.||::..
 Frog   704 ESEEEEEPHKSVSPTSPLQGMAYSAQLQAALARIPKKPPP--------EYPGP-RKSISNGALRH 759

  Fly   731 IYENVPLPQRASGGSSGAANTEAMRQR---ASSIQSAPGVVPVPAARNASSNNVVTVTVNSPPD- 791
            ...|:         ||..|..:||.||   |:.|....     |||.|.||.....    |.||
 Frog   760 ESSNI---------SSVIARAKAMSQRPCQAACISKTE-----PAAMNGSSLGPSI----SEPDL 806

  Fly   792 ---DGNIKKYGADRAASTELLFLEPQAPKRTNRAASAAPDMGATPPPRQHRSTASLNKSSTVDMI 853
               ...|||........:|:..:|                                      |:|
 Frog   807 TCVKERIKKEPVKERPVSEMFSIE--------------------------------------DVI 833

  Fly   854 TPAGDTLQQQFSAMNLSANTSASTSSMFNSTLDTTSSSAASKDLKRKKRWNFLSRSKTPDKQKSA 918
                  ::::....||                                           :||:.|
 Frog   834 ------VEREIMMRNL-------------------------------------------EKQEMA 849

  Fly   919 TLGREK-----ATTAGQHSKLAAKLKLAQDDLNLPNRWSTGVNKPQPISGRYSKDKLCQILDQKL 978
            .|..:|     |...|......|:.:..|||..|                 ...|:.|:.|..:|
 Frog   850 ALEAQKRPLMMAALNGLSVSRIARPEDRQDDTAL-----------------IQMDERCKTLRWRL 897

  Fly   979 SDSQLFMEFERIPKRREHALYECALLEENEPKNHDPNFLPYDDNRVRLTPCRDNRHGYVNASSIS 1043
            .:..:|.|:|:||||:...::..|:|.||..:|.....:||::|||.|.|.::|..||:|||.|.
 Frog   898 EEGMVFTEYEQIPKRKPEGVFTTAVLPENLERNRICEDIPYEENRVELVPTKENPTGYINASHIK 962

  Fly  1044 ATVGTKQRFYIVAQSPQEPLTMRIFWQCVWEADVYLVVQLTEDMS--------YIPR--NSHQRL 1098
            .||..|...||..|.|. |.|...|||.|||..|.::..:..|..        |.|:  ..|...
 Frog   963 VTVSGKDWHYIATQGPL-PHTFHDFWQMVWEQGVNVIAMVNADEEEGRAKSHRYWPKLGTKHNSE 1026

  Fly  1099 EFGQFQVYQEFSQTTDRCTTIKLRLYHVPSRRYRSVWYLQYADWAEQNCPRDVNHFLDFLEELNS 1163
            .:|:|:|...|...:....|..|::.|:.:.:.|:||:||:.||.:..||.::..||.:|||:.|
 Frog  1027 TYGKFKVTTNFRTDSGCYATTGLKVKHLLTGQERTVWHLQFTDWPDHGCPDEMQGFLSYLEEIRS 1091

  Fly  1164 VRLASTQEVPPGHNTNPPVLLHCLEGGGRSGVTLTADLLLYTLDHNEDLDIPRVIGQLRHQRDSI 1228
            ||    :...|....||||::||..|.||:||.:..:|::..|::||:::||.::..||.||..:
 Frog  1092 VR----RHANPSSLCNPPVVVHCSAGVGRTGVVVLTELMIRCLENNENIEIPAMLRHLREQRMFM 1152

  Fly  1229 IPSLAQYKFIYNLLITYLKRTRLI 1252
            |.::|||.|:|.:||.:||.:|||
 Frog  1153 IQTIAQYTFVYQVLIYFLKSSRLI 1176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pez	NP_001260127.1	B41	26..230	CDD:214604	68/205 (33%)
		FERM_N	26..93	CDD:286467	27/66 (41%)
		FERM_M	114..230	CDD:278785	36/117 (31%)
		FERM_C_PTPN14_PTPN21	225..317	CDD:270009	28/95 (29%)
		Y_phosphatase	1007..1243	CDD:278528	88/245 (36%)
		PTPc	1009..1243	CDD:238006	87/243 (36%)
ptpn14	XP_031758936.1	FERM_F1_PTPN14_like	18..102	CDD:340619	32/89 (36%)
		B41	22..220	CDD:214604	69/210 (33%)
		FERM_C_PTPN14_PTPN21	215..305	CDD:270009	28/94 (30%)
		PTPc-N14	889..1171	CDD:350447	103/286 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	190	1.000	Domainoid score	I3208
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I1616
OMA	1	1.010	-	-		QHG47166
OrthoDB	1	1.010	-	-		D144506at2759
OrthoFinder	1	1.000	-	-		FOG0004427
OrthoInspector	1	1.000	-	-		otm49420
Panther	1	1.100	-	-	LDO	PTHR45706
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3138
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.170