DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and RAPGEF2

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:XP_005263415.1 Gene:RAPGEF2 / 9693 HGNCID:16854 Length:1701 Species:Homo sapiens


Alignment Length:1748 Identity:614/1748 - (35%)
Similarity:836/1748 - (47%) Gaps:486/1748 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    34 LHQKCNR--GSHSSDTSSAYSGSDTMASNY-ASSLEAEEIDLSGLVESVVDS----DEEDLAESM 91
            ||.:...  .|||..:.::.|||.:::..| |:..||.::|||||.|:.|||    ||||:..:.
Human   195 LHPQVTHVSSSHSGCSITSDSGSSSLSDIYQATESEAGDMDLSGLPETAVDSEDDDDEEDIERAS 259

  Fly    92 DSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNITLAVRRALCSVMVFAVVDKAGTVV 156
            |.|..||.|||||||||.:|:::|:|.||||...|.||.|:|::|||.||:|||||||::|||:|
Human   260 DPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVERAGTIV 324

  Fly   157 MSDGEELDSWSVLINGAVEIEHANGSREELQMGDSFGILPTMDKLYHRGVMRTKCDDCQFVCITQ 221
            ::||||||||||::||:||:.:.:|..|.|.||:|||:.|||||.|.:||||||.||||||||.|
Human   325 LNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQFVCIAQ 389

  Fly   222 TDYYRIQHQGEENTRRHEDENGFVVMVTELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRG 286
            .||.||.:|.|:|.::.|:| |.:|||.|.|.:...||                  ::||:||:|
Human   390 QDYCRILNQVEKNMQKVEEE-GEIVMVKEHRELDRTGT------------------RKGHIVIKG 435

  Fly   287 TPERLLQQLVEENSMTDPTYVEDFLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTR 351
            |.|||...||||:|:.|||::||||||:|.|:.:|.||..|||.||:        ...|||:|||
Human   436 TSERLTMHLVEEHSVVDPTFIEDFLLTYRTFLSSPMEVGKKLLEWFN--------DPSLRDKVTR 492

  Fly   352 VVLLWVNNHFTDFEADYEMMEFLEVFEALLERKKLLSQLRLLHIACAAKARMRSCTLTRSSRDEP 416
            ||||||||||.|||.|..|..|||.||..|||:|:...||||:|||||||:.|..|||:.||:.|
Human   493 VVLLWVNNHFNDFEGDPAMTRFLEEFENNLEREKMGGHLRLLNIACAAKAKRRLMTLTKPSREAP 557

  Fly   417 LNFRIVGGYELRGVAIATGNAAVGIYISHVEPGSKAQDVGLKRGDQIHEVNGQSLDHVTSKRALE 481
            |.|.::||.|          ...||::..|:.||||.:.||||||||.|||||:.:::...:|:|
Human   558 LPFILLGGSE----------KGFGIFVDSVDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAME 612

  Fly   482 ILTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAKLHGR 546
            ||...|||||:||:||..|||::..|...                |...:|......||.|    
Human   613 ILRNNTHLSITVKTNLFVFKELLTRLSEE----------------KRNGAPHLPKIGDIKK---- 657

  Fly   547 SDSTTDELSSVSASNRAHMVRLSSVDMLLDQPDCAPPQTPPVSGSGNMASNFMQQL--LQSVNNS 609
                        ||      |.|..|:.:|                      ::|:  |:.||  
Human   658 ------------AS------RYSIPDLAVD----------------------VEQVIGLEKVN-- 680

  Fly   610 SAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNL-------LNKQNHGSSLNDSSDTLLND 667
              |||..|       |.||      :.:|:|.|.|..:       .|....|.|.:||...|   
Human   681 --KKSKAN-------TVGG------RNKLKKILDKTRISILPQKPYNDIGIGQSQDDSIVGL--- 727

  Fly   668 PKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQVNYLNA 732
                        ..|:.......|||    ..|.|||||                       |.:
Human   728 ------------RQTKHIPTALPVSG----TLSSSNPDL-----------------------LQS 753

  Fly   733 HIHRPSAASTLTTNSTQSHLLPDYPDHVLKVYKADQTCKYVLIYKETTAHEVVMLTLQEFGIHDP 797
            | ||     .|..::|     ||.||.||:|:||||..:|::|.|:|||.|||:..::||.:...
Human   754 H-HR-----ILDFSAT-----PDLPDQVLRVFKADQQSRYIMISKDTTAKEVVIQAIREFAVTAT 807

  Fly   798 SSNFSLCEVSVGDGGMVKQRRLPDQLQNLAERISFAARYYLKLNDSTEPLVPDELALELVRESNV 862
            ...:|||||||...|::|||||||||..||:||..:.|||||.|..||.|..||.|.||:|||.:
Human   808 PDQYSLCEVSVTPEGVIKQRRLPDQLSKLADRIQLSGRYYLKNNMETETLCSDEDAQELLRESQI 872

  Fly   863 HFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRYGVPMLSKFAELVNREMFWVVSEIC 927
            ..|.|:..|:|.||::::|..||.||.|||:|:||:|||:.....|.:|.|::|:|.|||.|||.
Human   873 SLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDLFKLRSKTSCANLKRFEEVINQETFWVASEIL 937

  Fly   928 AEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQRLFNDLQ 992
            .|.|.::||||:|.|||||.||:||:||||||||:|||....|:|||.||||||:||::||.|||
Human   938 RETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQ 1002

  Fly   993 DLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDTRVDGLINFEKLRMLAKEVR 1057
            ||.||||||:|||.:::::.| |.||||.:|::||||||:|.|||::||||:|||||||:|||:|
Human  1003 DLFDPSRNMAKYRNVLNSQNL-QPPIIPLFPVIKKDLTFLHEGNDSKVDGLVNFEKLRMIAKEIR 1066

  Fly  1058 LLTHMCSSPYDLLSILELKGQSPSNALFSLNQMSASQSNAAAGTV--IAANAGQATIKRRKKSTA 1120
            .:..|.|...|    ..|..::......||..:|...:||   ||  :|...|.   |:|.:.::
Human  1067 HVGRMASVNMD----PALMFRTRKKKWRSLGSLSQGSTNA---TVLDVAQTGGH---KKRVRRSS 1121

  Fly  1121 APNPKKMFEEAQMVRRVKAYLNSLKILSDEDLLHKFSLECEPAHGSTYSGSISHGNTSHRSGGGG 1185
            ..|.||::|:|||.|:||.||::|::..||:.|...||:||||           .||..:     
Human  1122 FLNAKKLYEDAQMARKVKQYLSNLELEMDEESLQTLSLQCEPA-----------TNTLPK----- 1170

  Fly  1186 SISGGAGGSSGGGGGGSSSLNAGDQLSIYSHTSSSSAPNSSLSLRKRHPSSPTLSTTSSTSSTSD 1250
                                |.||:..:.|.||               |.:|...:.....|...
Human  1171 --------------------NPGDKKPVKSETS---------------PVAPRAGSQQKAQSLPQ 1200

  Fly  1251 HQRR--QMH--NNG--------------------PKFGTASPQAVKKMLSLSESSKIRPH----Q 1287
            .|::  ..|  |.|                    |.||..||||:||:|||||...:..|    :
Human  1201 PQQQPPPAHKINQGLQVPAVSLYPSRKKVPVKDLPPFGINSPQALKKILSLSEEGSLERHKKQAE 1265

  Fly  1288 PFVPRHGSTMAGVIPPLHHMHAAHGFSTPSPGGVVTSPATSAVANVQCTPSPSPC---------- 1342
            ..:....|.::.  ||....      |:|..||......:.....:..|.|.|..          
Human  1266 DTISNASSQLSS--PPTSPQ------SSPRKGGSGNQLRSFGSGQLDLTSSSSSLGSENSNKNNN 1322

  Fly  1343 SHRRLASGGNIIPSRAI---HERSHSDTPAPPPPLPSVDLSLESSSV--TTFRDLPL-------- 1394
            :.|....|..:.||..:   .:..||            ::|..||.|  ::|..:|:        
Human  1323 APRTYGIGYTLAPSGTVDNFSDSGHS------------EISSRSSIVSNSSFDSVPVSLHDERRQ 1375

  Fly  1395 RKSVT------------------------------------------------------------ 1399
            |.||:                                                            
Human  1376 RHSVSIVETNLGMGRMERRTMIEPDQYSLGSYAPMSEGRGLYATATVISSPSTEELSQDQGDRAS 1440

  Fly  1400 -------SGSISSCDSG-------YVHQQQ-------HYHLQY---------------------- 1421
                   .||.:||.||       ..||:.       |.|..|                      
Human  1441 LDAADSGRGSWTSCSSGSHDNIQTIQHQRSWETLPFGHTHFDYSGDPAGLWASSSHMDQIMFSDH 1505

  Fly  1422 -----QQQQQQNSSQHEPSPPVYTAA----------DCRLLQQISNNAVTRNL-NSPCQSTNTPP 1470
                 :|.|.:.|.:...|...:.::          |...:::.....|:... :|...|..|..
Human  1506 STKYNRQNQSRESLEQAQSRASWASSTGYWGEDSEGDTGTIKRRGGKDVSIEAESSSLTSVTTEE 1570

  Fly  1471 STPTPPPNQPTATIQLSAPPTAAAYMHARSQHQQLQQQQQSLAMPPPPPPPY-NVP----PLGSI 1530
            :.|.|.|    |.|.:::..|.........::::          |||.||.| .:|    |.|  
Human  1571 TKPVPMP----AHIAVASSTTKGLIARKEGRYRE----------PPPTPPGYIGIPITDFPEG-- 1619

  Fly  1531 YSH--------------------HQGTAGSRHLNHMHGKTTGPQERWFPDCRPTTKQQ 1568
            :||                    ...|||...:...||..|        ..||..|.|
Human  1620 HSHPARKPPDYNVALQRSRMVARSSDTAGPSSVQQPHGHPT--------SSRPVNKPQ 1669

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 70/108 (65%)
RasGEFN 279..400 CDD:214571 71/120 (59%)
PDZ_signaling 404..494 CDD:238492 41/89 (46%)
DegQ <422..494 CDD:223343 32/71 (45%)
PDZ_GEF_RA 757..841 CDD:176380 46/83 (55%)
RasGEF 871..1050 CDD:279011 109/178 (61%)
Rhomboid_SP 1252..>1357 CDD:289371 32/142 (23%)
RAPGEF2XP_005263415.1 CAP_ED 37..143 CDD:237999
cNMP 297..412 CDD:197516 72/115 (63%)
RasGEFN 428..541 CDD:214571 71/120 (59%)
PDZ_signaling 545..625 CDD:238492 41/89 (46%)
degP_htrA_DO <565..689 CDD:273938 59/204 (29%)
RA_PDZ-GEF1 769..851 CDD:340483 44/81 (54%)
RasGEF 874..1099 CDD:238087 125/229 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 239 1.000 Domainoid score I2286
eggNOG 1 0.900 - - E1_KOG3629
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 882 1.000 Inparanoid score I402
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D21656at33208
OrthoFinder 1 1.000 - - FOG0002053
OrthoInspector 1 1.000 - - otm41882
orthoMCL 1 0.900 - - OOG6_104221
Panther 1 1.100 - - O PTHR23113
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 1 1.000 - - X1353
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.860

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