DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment PDZ-GEF and CDC25

DIOPT Version :9

Sequence 1:NP_609012.2 Gene:PDZ-GEF / 33881 FlyBaseID:FBgn0265778 Length:1573 Species:Drosophila melanogaster
Sequence 2:NP_013413.1 Gene:CDC25 / 851019 SGDID:S000004301 Length:1589 Species:Saccharomyces cerevisiae


Alignment Length:1401 Identity:276/1401 - (19%)
Similarity:469/1401 - (33%) Gaps:481/1401 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 NRGSHSSDTSSAYSGSDTMASNYASSL----EAEEIDLSGLVESVVDSDEE-------------- 85
            |.....|.|.|..|.|:   .|.:|.|    :::|.|  |...|:.|.|..              
Yeast   358 NANIEDSSTRSKQSESE---QNRSSLLMEKQDSKETD--GNNNSINDDDNNNENNKNEFNEAGPS 417

  Fly    86 --------DLAESMDSLTVRDAVRDCLEKDPAERSEEDVEVLLEFTQGLKAFTNI-TLAVRRALC 141
                    ||.:::.|..|..:....|.|.         ::...:::.:|.:|.: .|.|.....
Yeast   418 SLNSLSAPDLTQNIQSRVVAPSRSSILAKS---------DIFYHYSRDIKLWTELQDLTVYYTKT 473

  Fly   142 SVMVFAVVDKAGTVVMSDGEELDSWSVLIN--GAVEIEH---ANGSREELQMGDSF-GILPTM-- 198
            :..:|.   |...:..:...:|.|.|::..  |...::|   |....:|::  ..| |::.::  
Yeast   474 AHKMFL---KENRLNFTKYFDLISDSIVFTQLGCRLMQHEIKAKSCSKEIK--KIFKGLISSLSR 533

  Fly   199 ---------DKLYHRGVMRT---KCDDCQFVCITQTDYYRIQHQGEENTRRHEDENGFVVM--VT 249
                     |..:||..|.|   |.:|.|                |.|..|.|.::|.:.:  |.
Yeast   534 ISINSHLYFDSAFHRKKMDTMNDKDNDNQ----------------ENNCSRTEGDDGKIEVDSVH 582

  Fly   250 ELRSIGGAGTDSAGSGGSATGASASLNMKRGHVVIRGTPERLLQQLVEENSMTD-----PTYVED 309
            :|.|:     ..:|....:|..:.:|           ||.|.....|.||.|.:     |....:
Yeast   583 DLVSV-----PLSGKRNVSTSTTDTL-----------TPMRSSFSTVNENDMENFSVLGPRNSVN 631

  Fly   310 FLLTHRIFIQNPQEVTSKLLHWFDLEQVDAHKTQELRDRVTRVVLLWVNNHFTDFEADYEMMEFL 374
            .::|.|..|||.           .||.....                 |.:|...::.|||::  
Yeast   632 SVVTPRTSIQNS-----------TLEDFSPS-----------------NKNFKSAKSIYEMVD-- 666

  Fly   375 EVFEALLERKKLLSQLRLLHIAC------------------------------------------ 397
                  :|..|.|..::||:...                                          
Yeast   667 ------VEFSKFLRHVQLLYFVLQSSVFSDDNTLPQLLPRFFKGSFSGGSWTNPFSTFITDEFGN 725

  Fly   398 AAKAR-MRSCTLTRSSRDEPLNFRI----------VGGYELRG-----VAIATGNAAVGIYI--- 443
            |.|.: :.|..:|.||.......||          ..||....     :.:...:||.|...   
Yeast   726 ATKNKAVTSNEVTASSSKNSSISRIPPKMADAIASASGYSANSETNSQIDLKASSAASGSVFTPF 790

  Fly   444 ---SHVEPGSKAQ---------------DVGLKRGDQIHE-VNGQSLDH--VTSK-----RALEI 482
               ||....|:|:               :...|:..||.| :|..:.:|  :.||     |.|||
Yeast   791 NRPSHNRTFSRARVSKRKKKYPLTVDTLNTMKKKSSQIFEKLNNATGEHLKIISKPKSRIRNLEI 855

  Fly   483 LTGTTHLSISVKSNLLGFKEIMQALEHGGGTAGSGSISAGSGSFKSVRSPRRICANDIAK----L 543
            .:.|..   .:..|:| ..||::.|:          :|........:::|..:.  |:..    :
Yeast   856 NSSTYE---QINQNVL-LLEILENLD----------LSIFINLKNLIKTPSILL--DLESEEFLV 904

  Fly   544 HGRS--DSTTDELSSVSASNRAHMVRL--SSVDMLLDQPDCAPPQTPPVSGSGNMASNF---MQQ 601
            |..|  .|...|...:..:....::||  ::....||.|..          ..:|.|||   ..:
Yeast   905 HAMSSVSSVLTEFFDIKQAFHDIVIRLIMTTQQTTLDDPYL----------FSSMRSNFPVGHHE 959

  Fly   602 LLQSVNNSSAKKSGGNSNSDQQDTKGGFMTLAPKRRLQKALAKMNLLNKQ----NHGSSLNDSSD 662
            ..::::|:..             .||.|    .|:..|.||:..::|..|    |:...||:|.|
Yeast   960 PFKNISNTPL-------------VKGPF----HKKNEQLALSLFHVLVSQDVEFNNLEFLNNSDD 1007

  Fly   663 TLLNDPKSKLSAVSSCSSSTQSSINGCTVSGGGRLYQSQSNPDLTSLNYDGGSDAGGNGGGRLQV 727
              ..|         :|....:.|...|.:.  .:|.:.:.|    .|||          ..|:..
Yeast  1008 --FKD---------ACEKYVEISNLACIIV--DQLIEEREN----LLNY----------AARMMK 1045

  Fly   728 NYLNA--------------------------------------HIHRPSAASTLTTNSTQS---H 751
            |.|.|                                      :|.|.:|      |..::   .
Yeast  1046 NNLTAELLKGEQEKWFDIYSEDYSDDDSENDEAIIDDELGSEDYIERKAA------NIEKNLPWF 1104

  Fly   752 LLPDYPDHVLKVY----KADQTCKYVLIYKETTAHEVV--------------MLTLQEF------ 792
            |..||...:  ||    |.....|..|| :..|:||:|              :||.:||      
Yeast  1105 LTSDYETSL--VYDSRGKIRGGTKEALI-EHLTSHELVDAAFNVTMLITFRSILTTREFFYALIY 1166

  Fly   793 --GIHDP--------------SSNFSLCEV-----------------------SVGDGGMVKQRR 818
              .::.|              .||...|.|                       .:....||...:
Yeast  1167 RYNLYPPEGLSYDDYNIWIEKKSNPIKCRVVNIMRTFLTQYWTRNYYEPGIPLILNFAKMVVSEK 1231

  Fly   819 LP---DQLQNLAERI---------------SFAARYYLKLNDSTEPL------VPDELALELVRE 859
            :|   |.||.:.|::               |.:|.......|:..|:      :|...:....|.
Yeast  1232 IPGAEDLLQKINEKLINENEKEPVDPKQQDSVSAVVQTTKRDNKSPIHMSSSSLPSSASSAFFRL 1296

  Fly   860 SNVHFLHLNAYELAIQLTLQDFANFRQIESTEYVDELFELRSRY----GVPMLSKFAELVNREMF 920
            ..:..|.::.|..|.|||:.:...:.:|...|.:|..:  .::|    |.|.::||....|....
Yeast  1297 KKLKLLDIDPYTYATQLTVLEHDLYLRITMFECLDRAW--GTKYCNMGGSPNITKFIANANTLTN 1359

  Fly   921 WVVSEICAEHNIVRRMKIVKQFIKIARHCKECRNFNSMFAIVSGLGHGAVSRLRQTWEKLPSKYQ 985
            :|...|..:.::..|.|:.:.|:.:|:||||..||:||.||||.|....:.||::||:.:.::.:
Yeast  1360 FVSHTIVKQADVKTRSKLTQYFVTVAQHCKELNNFSSMTAIVSALYSSPIYRLKKTWDLVSTESK 1424

  Fly   986 RLFNDLQDLMDPSRNMSKYRQLVSAELLAQHPIIPFYPIVKKDLTFIHLGNDT---RVDGLINFE 1047
            .|..:|.:|||..||..|||:|:.:  :.....:||:.:...||||..:||..   ....:|||.
Yeast  1425 DLLKNLNNLMDSKRNFVKYRELLRS--VTDVACVPFFGVYLSDLTFTFVGNPDFLHNSTNIINFS 1487

  Fly  1048 KLRMLAKEVRLLTHMCSSPY------DLLSILE--LKGQSPSNALFSLN-QMSASQSNAAAGTVI 1103
            |...:|..|..:.......|      |:.:::|  |:........:.|: |:.....|....|..
Yeast  1488 KRTKIANIVEEIISFKRFHYKLKRLDDIQTVIEASLENVPHIEKQYQLSLQVEPRSGNTKGSTHA 1552

  Fly  1104 AANAGQATIKRRKKSTAAPN-----------PKKMF 1128
            ::.:|..|.|...:.|...|           |.::|
Yeast  1553 SSASGTKTAKFLSEFTDDKNGNFLKLGKKKPPSRLF 1588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PDZ-GEFNP_609012.2 CAP_ED 128..237 CDD:237999 24/129 (19%)
RasGEFN 279..400 CDD:214571 26/167 (16%)
PDZ_signaling 404..494 CDD:238492 28/133 (21%)
DegQ <422..494 CDD:223343 22/105 (21%)
PDZ_GEF_RA 757..841 CDD:176380 28/164 (17%)
RasGEF 871..1050 CDD:279011 59/185 (32%)
Rhomboid_SP 1252..>1357 CDD:289371
CDC25NP_013413.1 SH3_Sdc25 62..122 CDD:212816
RasGEFN 1117..1246 CDD:214571 24/129 (19%)
RasGEF 1301..1543 CDD:214539 69/245 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.940

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